Carbamezapine for pain management in Guillain-Barré syndrome patients in the intensive care unit

Abstract

The pain in GBS has a dual origin, and we recommend CBZ as an adjuvant to treat pain in GBS patients, during the recovery phase in the ICU, to reduce the narcotic requirement.

Supportive Care for Patients With Guillain-Barré Syndrome

“…44 There was prompt substantial and significant relief of pain and reduction in the need for rescue medication. In a similar study 45 of 12 patients, greater pain relief was obtained from carbamazepine (300 mg daily for 3 days) than from placebo. Excellent relief of intractable and severe pain by epidural infusions of morphine (1-to 4-mg morphine bolus injections every 8-24 hours) has been reported in a single case study.…”

Manejo del dolor en el síndrome de Guillain-Barré. Revisión sistemática

“…En total se encontraron 14 publicaciones [8][9][10][11][12][13][14][15][16][17][18][19][20][21] . Diez eran reportes de casos, y 4 8,17,19,20 , ensayos aleatorizados, doble ciego, controlados, comparados frente a placebo, 3 de ellos realizados en UCI.…”

“…Diez eran reportes de casos, y 4 8,17,19,20 , ensayos aleatorizados, doble ciego, controlados, comparados frente a placebo, 3 de ellos realizados en UCI. Un estudio evaluó el uso de carbamazepina, otro, de gabapentina, un tercero comparó el uso de carbamazepina y gabapentina, y el último estudio evaluó el uso de metilprednisolona.…”

Advances in the management of Guillain-Barré syndrome

“…Epidural anesthesia is often an effective option, especially for the lumbar pain. One recent double-blind, randomized study looked at the use of carbamazepine as an alternative for pain control [16]. Twelve mechanically ventilated patients with GBS and severe back or leg cramps requiring opioids were given either placebo or 100 mg of carbamazepine every 8 hours for 3 days.…”