Carbamazepine‐related ejaculatory failure

Leris, A.C.A.; Stephens, John C.; Hines, J.E.W.; McNicholas, Tom

doi:10.1046/j.1464-410x.1997.11336.x

Cited by 12 publications

(4 citation statements)

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“…Ejaculatory failure (unaccompanied by ED or a reduction in libido) has also been reported in a man taking CBZ for trigeminal neuralgia 127 and in another taking gabapentin for hypomania 128 . In both cases orgasm and ejaculation returned to normal after withdrawing the AED, suggesting that medication even in the absence of a seizure history may be associated with sexual dysfunction.…”

Section: Studies Conducted In Subjects Not Suffering From Epilepsymentioning

confidence: 86%

Seizures, hormones and sexuality

Lambert¹

2001

Seizure

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Sexual disorders (both hyposexuality and sexual dysfunction) are common in people with epilepsy, occurring in up to two-thirds of patients. However, characteristically, patients do not spontaneously report these problems. Nocturnal penile tumescence testing suggests that the erectile dysfunction has a neurophysiological component. The aetiology remains uncertain but is likely to be multifactorial, involving neurological, endocrine, iatrogenic, cognitive, psychiatric and psychosocial factors. Epilepsy-related factors include the age of onset/duration of epilepsy along with the seizure type and focus. In addition, seizure frequency might be relevant as successful epilepsy surgery can result in an improvement in sexual functioning despite remaining on anticonvulsant medication. Endocrine changes (raised sex hormone binding globulin and reduced free testosterone) have been reported in men with epilepsy, especially when treated with hepatic-enzyme inducing antiepileptic drugs. Studies have not been performed evaluating anticonvulsants that do not induce hepatic enzymes such as lamotrigine. The association between these endocrine changes and hyposexuality is not known. The relationship between seizures, hormones and anticonvulsant medication in women is explored, focusing on issues such as catamenial epilepsy, the menopause, hormone replacement therapy and the polycystic ovarian syndrome. Suggestions for future research and treatment issues are discussed.

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Section: Studies Conducted In Subjects Not Suffering From Epilepsymentioning

confidence: 86%

Seizures, hormones and sexuality

Lambert¹

2001

Seizure

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“…The other AEDs patients were taking in this study included lamotrigine, levetiracetam, topiramate and valproate. The other types of sexual dysfunction that have been reported in the use of carbamazepine are much rarer and limited to single case reports, including ejaculatory failure (78) and hypersexuality (79).…”

Section: Carbamazepinementioning

confidence: 99%

Sexual Dysfunction in Epilepsy and the Role of Anti-Epileptic Drugs

Yogarajah

Mula

2018

CPD

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“…Sexual dysfunction, including ED, occurs in nearly two thirds of people with epilepsy and is attributed to changes in sex hormone levels due to the disease or treatment with AEDs 11 . In particular, iatrogenic sexual dysfunction in men resulting from carbamazepine has been well documented 4,5 . As shown in the four cases of men with epilepsy presented in this report, switching from carbamazepine to oxcarbazepine may have significantly improved erectile function in carbamazepine-induced ED.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, carbamazepine can increase plasma levels of sex hormone-binding globulin (SHBG), consequently decreasing the unbound biologically active form of testosterone, which leads to sexual dysfunction in some men 2,3 . In particular, complaints of erectile dysfunction (ED), hypoactive sexual desire disorder, inhibited orgasm, and premature ejaculation have been reported in men taking carbamazepine 4,5 .…”

Section: Introductionmentioning

confidence: 99%

Amelioration of erectile dysfunction following a switch from carbamazepine to oxcarbazepine: recent clinical experience

Sachdeo

Sathyan

2005

Current Medical Research and Opinion

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Oxcarbazepine is an antiepileptic drug (AED) indicated for use as monotherapy and add-on therapy in adults and children 4 years of age and older. Despite being structurally related to carbamazepine, oxcarbazepine differs substantially in its pharmacokinetic and safety profile; oxcarbazepine has a much lower risk of pharmacokinetic drug-drug interactions than carbamazepine. Carbamazepine has also been shown to induce the hepatic synthesis of sex hormone-binding globulin, thus reducing free serum testosterone levels and possibly causing erectile dysfunction (ED) in some men; these effects have not been observed with oxcarbazepine. This paper provides a discussion of recent clinical experience with men who presented in private clinical practice with complaints of ED while being treated with carbamazepine for seizure disorders. The four illustrative case studies presented in this report suggest that switching AED treatment from carbamazepine to oxcarbazepine in men with epilepsy can reduce the ED side effects observed with carbamazepine.

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Carbamazepine‐related ejaculatory failure

Cited by 12 publications

References 0 publications

Seizures, hormones and sexuality

Seizures, hormones and sexuality

Sexual Dysfunction in Epilepsy and the Role of Anti-Epileptic Drugs

Amelioration of erectile dysfunction following a switch from carbamazepine to oxcarbazepine: recent clinical experience

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