Carbamazepine induces upward frequency shifts of spontaneous otoacoustic emissions

Kleine, Emile de; Maat, Bert; Metzemaekers, Jan D. M.; Dijk, Pim van

doi:10.1016/j.heares.2022.108492

Cited by 3 publications

(6 citation statements)

References 25 publications

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“…DPOAE group delay time for the capsaicin treated groups was significantly prolonged compared to either the pre‐injection or DMSO group (Figure 9I,J), supporting the idea that functional alteration of OHCs can change frequency place coding. Our result echoes the clinically observed pitch shift observed after carbamazepine treatment 10 …”

Section: Resultssupporting

confidence: 90%

“…Since age‐related OHC surface area reduction involves both morphological and functional changes, both passive and active components of cochlea would be affected by aging. Recently, De Klein et al 10 found that human subjects who were prescribed carbamazepine experienced changes in pitch perception and an upward shift in spontaneous otoacoustic emission (SOAE) frequencies. Presumably, only a functional change occurred in such cases, which could lead to a situation where the functional change of OHC could produce a rescaling of the frequency coding.…”

Section: Resultsmentioning

confidence: 99%

“…There are case reports where human subjects who received carbamazepine experience a shift in pitch perception 92 . In a recent report, de Kline et al presented evidence that this type of pitch perception change has a peripheral source: SOAE shifted toward a higher frequency by about a semitone, 10 a number matching previous estimates in mice 8 . As the shift in frequency coding could happen with or without morphological changes in OHCs, we expect that such a process can be either compensated or retarded.…”

Section: Discussionmentioning

confidence: 99%

“…8 This prolonged DPOAE group delay finding led us to propose an age-related frequency place rescaling and remapping along the cochlear length. 8 In a recent human study, de Kleine et al 10 described a drug-induced upward shift in spontaneous otoacoustic emission frequencies that may have derived from functional changes in the cochlear amplifier.…”

Section: Introductionmentioning

confidence: 99%

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Differential outcomes of high‐fat diet on age‐related rescaling of cochlear frequency place coding

Zhang,

Lin,

Xue

et al. 2023

The FASEB Journal

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Auditory frequency coding is place‐specific, which depends on the mechanical coupling of the basilar membrane‐outer hair cell (OHC)‐tectorial membrane network. Prestin‐based OHC electromotility improves cochlear frequency selectivity and sensitivity. Cochlear amplification determines the frequency coding wherein discrete sound frequencies find a ‘best’ place along the cochlear length. Loss of OHC is the leading cause of age‐related hearing loss (ARHL) and is the most common cause of sensorineural hearing loss and compromised speech perception. Lipid interaction with Prestin impacts OHC function. It has been established that high‐fat diet (HFD) is associated with ARHL. To determine whether genetic background and metabolism preserve cochlear frequency place coding, we examined the effect of HFD in C57BL/6J (B6) and CBA/CaJ (CBA) on ARHL.We found a significant rescuing effect on ARHL in aged B6 HFD cohort. Prestin levels and cell sizes were better maintained in the experimental B6‐HFD group. We also found that distortion product otoacoustic emission (DPOAE) group delay measurement was preserved, which suggested stable frequency place coding. In contrast, the response to HFD in the CBA cohort was modest with no appreciable benefit to hearing threshold. Notably, group delay was shortened with age along with the control. In addition, the frequency dependent OHC nonlinear capacitance gradient was most pronounced at young age but decreased with age. Cochlear RNA‐seq analysis revealed differential TRPV1 expression and lipid homeostasis. Activation of TRPV1 and downregulation of arachidonic acid led to downregulation of inflammatory response in B6 HFD, which protects the cochlea from ARHL. The genetic background and metabolic state‐derived changes in OHC morphology and function collectively contribute to a redefined cochlear frequency place coding and improved age‐related pitch perception.

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Section: Resultssupporting

confidence: 90%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Differential outcomes of high‐fat diet on age‐related rescaling of cochlear frequency place coding

Zhang,

Lin,

Xue

et al. 2023

The FASEB Journal

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“…De Kleine et al [2022] recently gave a summary of the experimental procedures that can cause a change in the frequency of human SOAEs (their Fig. 5).…”

Section: Discussionmentioning

confidence: 99%

Frequency Shifts in a Local Oscillator Model for the Generation of Spontaneous Otoacoustic Emissions by the Lizard Ear

Wit¹,

Bell²

2023

Audiol Neurotol

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Introduction: In order to understand human hearing, it helps to understand how the ears of lower vertebrates, like, for instance, lizards, function. A key feature in common is that the ears of both humans and lizards emit faint, pure tones known as spontaneous otoacoustic emissions (SOAEs). More than four decades after their discovery, the mechanism underlying these emissions is still imperfectly understood, although it is known that they are important for improving the sensitivity and sharpness of hearing. In both humans and lizards, the frequencies of SOAEs change by a few percent when static pressure is applied to the tympanic membrane. For the human ear, this observation is normally explained by a so-called global oscillator model (such as with Shera’s coherent reflection model), in which the emissions result from standing waves, and external pressure changes the boundary conditions – the stiffness of the oval and round windows – which then has a global effect on the SOAE frequencies. Methods: Here we investigate how changing parameters of an earlier developed local oscillator model for the lizard ear can change the frequencies of the SOAEs. A major feature of the model is that each oscillator is coupled only to its immediate neighbours. The oscillators then cluster into groups of identical frequency, and each of these so-called frequency plateaus can be taken to represent an SOAE. Results: Even though the natural (unperturbed) frequencies of all the oscillators remain fixed, here we find for several model parameters that by slightly changing their value the frequency plateaus – the SOAEs – shift by a few percent. Plots of how these changes alter SOAE frequencies are given, and their magnitude corresponds well with observations of SOAE changes in lizards. Discussion: Investigation of the influence of the change of parameters in an earlier developed local oscillator model for the lizard ear shows that a local oscillator model can explain small SOAE frequency changes as well as a global oscillator model.

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Carbamazepine and Bipolar Disorder: Pharmacodynamics, Pharmacokinetics, Pharmacogenomics, and Adverse Drug Reactions- A Comprehensive Review

P.,

Banerjee,

Bansal

et al. 2023

Asian J Pharm Pharmacol

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Bipolar disorder is a chronic recurring illness marked by swings in mood and energy. Regardless of nationality, ethnic background, or socioeconomic status, it affects more than 1% of the world's population1. It is marked by recurring episodes of mania and depression in bipolar disorder (Carvalho et al., 2020) and of hypomania and depression in bipolar disorder (Harrison et al., 2018). Patients with bipolar disorder usually have additional medical conditions in addition to their serious mental disorders (Zareifopoulos et al., 2018). There is evidence of a neurotransmission imbalance, polygenic inheritance, and illness progression in these individuals. Patients frequently take many medications at once, with varying degrees of therapeutic efficacy, especially in the case of depression. Numerous people commit suicide (Dome et al., 2019). In comparison to the general population, the suicide rate is 5-17 times greater, with a lifetime risk of 10%-20% (Miller and Black, 2020).Anticonvulsant medications are frequently prescribed for these psychiatric purposes. Although various additional anticonvulsant medications have been tested with conflicting or inconclusive results, carbamazepine, valproate, and lamotrigine are known mood stabilizers for bipolar disorder (Simonetti et al., 2020). Carbamazepine (CBZ) is a crucial second-line treatment for bipolar disorder when treatment with a conventional antipsychotic alone fails. CBZ otherwise is typically used in the treatment of seizure disorders and neuropathic pain (Sparacino et al., 2022). CBZ is structurally similar to tricyclic antidepressant imipramine. In 2002, the FDA gave CBZ the drug approved for the treatment of acute mania (Sparacino et al., 2022). Hence this review in detail discusses carbamazepine for the treatment of bipolar disorder, its underlying mechanism, and adverse effects.

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Carbamazepine induces upward frequency shifts of spontaneous otoacoustic emissions

Cited by 3 publications

References 25 publications

Differential outcomes of high‐fat diet on age‐related rescaling of cochlear frequency place coding

Differential outcomes of high‐fat diet on age‐related rescaling of cochlear frequency place coding

Frequency Shifts in a Local Oscillator Model for the Generation of Spontaneous Otoacoustic Emissions by the Lizard Ear

Carbamazepine and Bipolar Disorder: Pharmacodynamics, Pharmacokinetics, Pharmacogenomics, and Adverse Drug Reactions- A Comprehensive Review

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