Carbamazepine for Kleine-Levin Syndrome

Mukaddes, Nahit Motavallı; Kora, Meltem; Bilge, Sumru

doi:10.1097/00004583-199907000-00001

Cited by 35 publications

(14 citation statements)

References 3 publications

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“…Several studies have been reported to support that mood stabilizer Lithium decreases the length and severity of symptoms and delays the time between episodes [ 11 ]. Though antiepileptic drugs like carbamazepine and valproic acid are less effective than lithium, they are preferred due to less side effects [ 12 ]. Central nervous system stimulant drugs such as modafinil, amphetamines and methylphenidate help in wakefulness and alleviating the hypersomnia during episodes but do not have disease stabilization effect [ 13 ].…”

Section: Discussionmentioning

confidence: 99%

Kleine-Levin syndrome with comorbid iron deficiency anemia

Jain

Kumar

Srivastava

et al. 2015

Oxford Medical Case Reports

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Kleine–Levin syndrome (KLS) is a rare chronic sleep disorder of unknown etiopathology, which typically occurs in adolescent males. Although the severity of symptoms and disease course varies between the KLS patients, it usually resolves spontaneously, but sometime comorbid conditions may worsen the symptoms. Herein, we report a case of KLS who presented with severe episodic hypersomnia. During episodes, the patient used to sleep as long as 20 h in a day, affecting his daily living activities. All the relevant investigations including electroencephalography, magnetic resonance imaging of brain and cerebrospinal fluid analysis were normal except for severe iron deficiency anemia (IDA). In our patient, the severity of symptoms worsened due to coexistent IDA. The treatment of IDA along with modafinil decreased the severity of symptoms and shortened the hospital stay during episodes. This might be the first case report of KLS with comorbid IDA.

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Section: Discussionmentioning

confidence: 99%

Kleine-Levin syndrome with comorbid iron deficiency anemia

Jain

Kumar

Srivastava

et al. 2015

Oxford Medical Case Reports

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“…On the contrary, some young patients become rude and aggressive, especially when prevented from resting. A child beat his grandmother, an adult patient beat his dog, 15 another child bit his father, a teenager spat on the face of his physician, 16 while a teenager had such an anger outburst at school that the police evacuated the classroom. 17 In one-third of patients, mild, shortlasting hallucinations (a snake near the bed, a dangerous man with a bear in the hospital lift) and delusions are described.…”

Section: Psychiatric Problemsmentioning

confidence: 99%

Kleine-Levin Syndrome

Arnulf

2015

Sleep Medicine Clinics

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“…Other mood stabilizers and antiepileptics studied have included valproic acid,44 carbamazepine,45 phenytoin, gabapentin,46 and lamotrigine. None of these have consistently demonstrated significant benefit.…”

Section: Treatmentmentioning

confidence: 99%

Kleine-Levin syndrome: a review

Miglis¹,

Guilleminault²

2014

NSS

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Kleine-Levin syndrome is a recurrent hypersomnia associated with symptoms of hyperphagia, hypersexuality, and cognitive impairment. This article reviews the current available research and describes common clinical symptoms, differential diagnosis, and acceptable workup and treatment. Although deficits have traditionally been thought to resolve between episodes, functional imaging studies and long-term neuropsychological testing in select patients have recently challenged this notion. This may suggest that Kleine-Levin syndrome is not as benign as previously considered.

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Carbamazepine for Kleine-Levin Syndrome

Cited by 35 publications

References 3 publications

Kleine-Levin syndrome with comorbid iron deficiency anemia

Kleine-Levin syndrome with comorbid iron deficiency anemia

Kleine-Levin Syndrome

Kleine-Levin syndrome: a review

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