Carbamates pesticides induced immunotoxicity and carcinogenicity in human: A review

Dhouib, Ines Bini; Annabi, Alya; Jallouli, Manel; Marzouki, Soumaya; Gharbi, N.; El-Fazaâ, Saloua; Lasram, Mohamed Montassar

doi:10.1016/j.jab.2016.01.001

Cited by 54 publications

(23 citation statements)

References 38 publications

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“…Significant differences were found in GSH and GSSG levels between the not exposed group and 4 occupational exposure sub-groups, indicating oxidative stress. A decrease in GSH/GSSG was observed as a result of exposure to OPs, carbamates and paraquat [ 7 , 9 , 23 , 24 , 27 , 39 – 41 ]. However, unlike our results, studies that have analyzed GSH and GSSG specifically in erythrocytes after exposure to OPs (as was done in the present study) reported high levels [ 42 , 43 ].…”

Section: Discussionmentioning

confidence: 99%

“…It destabilizes protein and lipid molecules [ 7 , 8 ]. The carbofuran is a carbamate pesticide and carbamic acid derivative which stimulates cholinergic hyperactivity and modifies redox potential while decreasing antioxidant status [ 9 ]. Consequently, factors that trigger systemic toxicity to pesticides are ROS and reactive nitrogen species (RNS) [ 9 – 11 ].…”

Section: Introductionmentioning

confidence: 99%

“…The carbofuran is a carbamate pesticide and carbamic acid derivative which stimulates cholinergic hyperactivity and modifies redox potential while decreasing antioxidant status [ 9 ]. Consequently, factors that trigger systemic toxicity to pesticides are ROS and reactive nitrogen species (RNS) [ 9 – 11 ]. The ROS are formed by partial reduction of molecular oxygen, and the main products are superoxide anion (O 2 − ) and H 2 O 2 [ 12 – 14 ].…”

Section: Introductionmentioning

confidence: 99%

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Occupational exposure to organophosphorus and carbamates in farmers in La Cienega, Jalisco, Mexico: oxidative stress and membrane fluidity markers

Salazar-Flores

Pacheco-Moisés

Ortíz

et al. 2020

J Occup Med Toxicol

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Background The region of La Cienega in Jalisco Mexico, is an important agricultural reference for the production of corn, sorghum and wheat, among other grains, so the use of pesticides for pest control is high. However, in this rural area there are no toxicological studies that assess the occupational risk of pesticide use. Therefore, this study is the first to determine the oxidative stress levels markers (GSH, GSSG, carbonyl groups, nitric oxide metabolites and lipid peroxides) as well as alteration of the mitochondrial membrane fluidity caused by occupational exposure to organophosphorus and carbamates in farmers of this region. This occupational risk can increase cellular oxidation, which explains the high prevalence of neurodegenerative diseases and cancer in Cienega settlers to be analyzed in future studies. Methods Comparative cross-sectional study was performed using two groups: one not exposed group (n = 93) and another one with occupational exposure (n = 113). The latter group was sub-divided into 4 groups based on duration of use/exposure to pesticides. Oxidative stress levels and membrane fluidity were assessed using spectrophotometric methods. Statistical analyses were performed using SPSS software ver. 19.0 for windows. Results The most commonly used pesticides were organophosphorus, carbamates, herbicide-type glyphosate and paraquat, with an average occupational exposure time of 35.3 years. There were statistically significant differences in markers of oxidative stress between exposed farmers and not exposed group (p = 0.000). However, in most cases, no significant differences were found in markers of oxidative stress among the 4 exposure sub-groups (p > 0.05). Conclusion In the Cienega region, despite the indiscriminate use of organophosphorus and carbamates, there are no previous studies of levels oxidative stress. The results show increased levels of oxidative stress in occupationally exposed farmers, particularly membrane fluidity levels increased three times in contrast to not exposed group.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Occupational exposure to organophosphorus and carbamates in farmers in La Cienega, Jalisco, Mexico: oxidative stress and membrane fluidity markers

Salazar-Flores

Pacheco-Moisés

Ortíz

et al. 2020

J Occup Med Toxicol

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“…Carbamate pesticides are the most widely used pesticides for pest prevention in fruits and vegetables. The previous studies indicated that carbamate pesticides could cause mutation, teratogenicity, and carcinogenesis [4,5]. According to GB 5009.21 and GB 14928.7‐94, the maximum residue limits of carbaryl in fruits and carbofuran in rice grains are 2.5 and 0.5 mg/kg, respectively.…”

Section: Introductionmentioning

confidence: 99%

Fe₃O₄ nanoparticles coated with polyhedral oligomeric silsesquioxanes and β‐cyclodextrin for magnetic solid‐phase extraction of carbaryl and carbofuran

Liu

Zhang

et al. 2020

J of Separation Science

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In this study, porous sandwich structure Fe 3 O 4 nanoparticles coated by polyhedral oligomeric silsesquioxanes and β-cyclodextrin were prepared by surface polymerization and were used as the magnetic solid phase extraction adsorbent for the extraction and determination of carbaryl and carbofuran. The Fe 3 O 4 nanoparticles coated with polyhedral oligomeric silsesquioxanes and β-cyclodextrin were characterized by Fourier transform infrared spectroscopy, X-ray diffraction, thermogravimetric analysis, vibrating sample magnetometry, and scanning electron microscopy. After optimizing the extraction conditions, a method that combined magnetic solid phase extraction with high-performance liquid chromatography was developed for the determination of carbaryl and carbofuran in apple. The method exhibited a good linearity in the range of 2-400 μg/kg for carbaryl and carbofuran (R 2 = 0.9995), respectively. The limits of detection were 0.5 μg/kg of carbaryl and 0.7 μg/kg for carbofuran in apple, respectively. Extraction recoveries ranged from 94.2 to 103.1% with the preconcentration factor of 300 and the relative standard deviations were less than 5.9%. These results indicated that the method combined magnetic solid phase extraction with high-performance liquid chromatography and was promising for the determination of carbaryl and carbofuran at trace amounts.

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“…Some pesticides are known or suspected carcinogens in humans and other organisms. Pesticides have been implicated in chronic and acute diseases such as leukemia, cancer, thyroid and nervous disorders, endocrine disruption and others (Lee et al 2004, Freeman et al 2005, Recio et al 2005, Lacasaña et al 2010, Alavanja and Bonner 2012, Starks et al 2012, Blanc-Lapierre et al 2013, Michalakis et al 2014, Dhouib et al 2016, Piccoli et al 2016, IARC 2017, Polanco Rodríguez et al 2017). Due to their environmental risk and toxicity, the use of certain pesticides has been restricted or banned in many countries.…”

Section: Introductionmentioning

confidence: 99%

Toxic Effects of Exposure to Pesticides in Farm Workers in Navolato, Sinaloa (Mexico)

Galindo-Reyes

Alegria

2018

Rev. Int. Contam. Ambie.

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The impact of chronic exposure to pesticides, especially among farmworkers, continues to be an area of research interest, especially in developing countries. This study aimed to measure and compare levels and profiles of pesticides in farm environments and farmworkers in an agricultural area of Mexico, as well as their effects in this cohort. Organochlorine and organophosphate pesticides were measured in soil and water samples from farms in the Navolato Valley, Sinaloa, Mexico. Levels of these pesticides as well as transaminases, alkaline phosphatase, acetylcholinesterase and hemoglobin were also measured in blood and urine from farmworkers of the study area and compared with levels in a control population. All 17 target organochlorine pesticides and four of nine target organophosphate pesticides were detected in soil and water samples. In farmworkers, 14 of 17 target organochlorine pesticides and seven of nine organophosphate pesticides were detected. Pesticide profiles were similar in farmworkers as in the environment. In comparison, only six organochlorine pesticides and three organophosphate pesticides were detected in control population, in much lower concentrations and with lower detection frequencies. Clinical analyses indicated that levels of transaminases and alkaline phosphatase were elevated while levels of hemoglobin and acetylcholinesterase were depressed in farmworkers compared to the control group. The results indicate that farmworkers are suffering from chronic exposure to workplace pesticides and could endure adverse health effects. Palabras clave: suelo, agua, análisis clínicos, sangre, orina RESUMEN El impacto de la exposición crónica a plaguicidas-especialmente entre los trabajadores agrícolas-es un área de interés para la investigación, especialmente en los países en desarrollo. Este estudio tuvo como objetivo medir y comparar los niveles y perfiles de los plaguicidas en el medio ambiente y los trabajadores agrícolas en una zona agrícola de México, así como sus efectos en este grupo de personas. Los niveles de plaguicidas

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Carbamates pesticides induced immunotoxicity and carcinogenicity in human: A review

Abstract: International audienceno abstrac

Cited by 54 publications

References 38 publications

Occupational exposure to organophosphorus and carbamates in farmers in La Cienega, Jalisco, Mexico: oxidative stress and membrane fluidity markers

Occupational exposure to organophosphorus and carbamates in farmers in La Cienega, Jalisco, Mexico: oxidative stress and membrane fluidity markers

Fe₃O₄ nanoparticles coated with polyhedral oligomeric silsesquioxanes and β‐cyclodextrin for magnetic solid‐phase extraction of carbaryl and carbofuran

Toxic Effects of Exposure to Pesticides in Farm Workers in Navolato, Sinaloa (Mexico)

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Carbamates pesticides induced immunotoxicity and carcinogenicity in human: A review

Abstract: International audienceno abstrac

Cited by 54 publications

References 38 publications

Occupational exposure to organophosphorus and carbamates in farmers in La Cienega, Jalisco, Mexico: oxidative stress and membrane fluidity markers

Occupational exposure to organophosphorus and carbamates in farmers in La Cienega, Jalisco, Mexico: oxidative stress and membrane fluidity markers

Fe3O4 nanoparticles coated with polyhedral oligomeric silsesquioxanes and β‐cyclodextrin for magnetic solid‐phase extraction of carbaryl and carbofuran

Toxic Effects of Exposure to Pesticides in Farm Workers in Navolato, Sinaloa (Mexico)

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Product

Resources

About

Fe₃O₄ nanoparticles coated with polyhedral oligomeric silsesquioxanes and β‐cyclodextrin for magnetic solid‐phase extraction of carbaryl and carbofuran