Caraway extract alleviates atopic dermatitis by regulating oxidative stress, suppressing Th2 cells, and upregulating Th1 cells in mice

Nosratabadi, Reza; Khajepour, Fardin; Zangouyee, MohammadReza; Khosravimashizi, Arezu; Afgar, Ali; Abdollahi, Vahideh; Dabiri, Shahriar

doi:10.4103/2221-1691.357741

Cited by 2 publications

(2 citation statements)

References 35 publications

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“…Studies have shown that the detection of MDA levels could be used as a test index for the symptoms of photoaged skin caused by ultraviolet exposure [ 58 ]. Fardin [ 59 ] used MDA as an antioxidant parameter to study oxidative stress degree in atopic dermatitis.…”

Section: Resultsmentioning

confidence: 99%

Design and Evaluation of Paeonol-Loaded Liposomes in Thermoreversible Gels for Atopic Dermatitis

Wang

Yue

Jia

et al. 2023

Gels

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Paeonol (PAE) is a hydrophobic drug. In this study, we encapsulated paeonol in a lipid bilayer of liposomes (PAE-L), which delayed drug release and increased drug solubility. When PAE-L was dispersed in gels (PAE-L-G) based on a poloxamer matrix material for local transdermal delivery, we observed amphiphilicity, reversible thermal responsiveness, and micellar self-assembly behavior. These gels can be used for atopic dermatitis (AD), an inflammatory skin disease, to change the surface temperature of the skin. In this study, we prepared PAE-L-G at an appropriate temperature for the treatment of AD. We then assessed the gel’s relevant physicochemical properties, in vitro cumulative drug release, and antioxidant properties. We found that PAE-loaded liposomes could be designed to increase the drug effect of thermoreversible gels. At 32 °C, PAE-L-G could change from solution state to gelatinous state at 31.70 ± 0.42 s, while the viscosity was 136.98 ± 0.78 MPa.S and the free radical scavenging rates on DPPH and H2O2 were 92.24 ± 5.57% and 92.12 ± 2.71%, respectively. Drug release across the extracorporeal dialysis membrane reached 41.76 ± 3.78%. In AD-like mice, PAE-L-G could also relieve skin damage by the 12th day. In summary, PAE-L-G could play an antioxidant role and relieve inflammation caused by oxidative stress in AD.

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Section: Resultsmentioning

confidence: 99%

Design and Evaluation of Paeonol-Loaded Liposomes in Thermoreversible Gels for Atopic Dermatitis

Wang

Yue

Jia

et al. 2023

Gels

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show abstract

“…The immune organ index was calculated according to the weight of immune organs, and it was used to characterize the degree of damage and health status of the immune organs. One week after CTX administration, the spleen index and thymus and cytotoxic T lymphocytes (Khajepour et al, 2022). Th2 cells produce IL-4, IL-6, IL-10, and IL-13, whose main function is to enhance cellular immunity, promote the proliferation of B lymphocytes, and generate antibodies (Espinosa Gonzalez et al, 2022).…”

Section: Effect Of Ldp-w On the Immune Organ Indexmentioning

confidence: 99%

Structural characterization of a polysaccharide from Lyophyllum decastes with MAPK-mediated immune regulation ability in mice

WANG

2023

Food Sci. Technol

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Lyophyllum decastes is a common macrofungi for both medicinal and economic value, and its polysaccharide has excellent development potential as a new immune regulator. In the present study, the bioactive component polysaccharide of L decastes was extracted, and its chain structure was characterized in detail by Fourier transform infrared (FT-IR) spectroscopy, high-performance gel-permeation chromatography (HP-GPC), and gas chromatography-mass spectrometry (GC-MS). LDP-W had a molecular weight of 2.12 × 10 4 Da, highly branched β type pyranose. At the same time, it exhibited potential immunomodulatory activity, which can modulate the numbers of CD3+, CD4+, CD8+ and CD19+ cells in the spleen; optimize the CD4+/CD8+ ratio; promoted T and B lymphocyte proliferation and it can elevate the levels of IL-2, IL-6, IFN-γ and TNF-α in immunosuppressed mice by influencing the phosphorylation of MAPK signaling-related proteins. These studies fill the gap in the immune regulation mechanism of L decastes polysaccharide, providing a theoretical basis for the potential application of LDP-W as immunomodulatory drugs or functional foods.

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Caraway extract alleviates atopic dermatitis by regulating oxidative stress, suppressing Th2 cells, and upregulating Th1 cells in mice

Cited by 2 publications

References 35 publications

Design and Evaluation of Paeonol-Loaded Liposomes in Thermoreversible Gels for Atopic Dermatitis

Design and Evaluation of Paeonol-Loaded Liposomes in Thermoreversible Gels for Atopic Dermatitis

Structural characterization of a polysaccharide from Lyophyllum decastes with MAPK-mediated immune regulation ability in mice

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