Caraway as Important Medicinal Plants in Management of Diseases

Abstract

Carum carvi or caraway is traditionally used for treatment of indigestion, pneumonia, and as appetizer, galactagogue, and carminative. Essential oil, fixed oil and many other valuable extractive compounds with industrial applications are prepared from caraway. This review article has new deep research on caraway as medicinal plant. For preparing the manuscript, the information was extracted from accessible international databases (Google scholar, PubMed, Science direct, Springer, and Wiley), electronic resources and traditional books by key word of caraway or Carum carvi. The results of traditional studies exhibited that the galactagogue and carminative effects of caraway fruits are superior to other effects. Although, the traditional scholars used it as appetizer, while caraway was the main ingredient of anti-obesity drugs in traditional medicine, which has been confirmed in two modern clinical trials of human studies. Caraway oil in combination with peppermint oil or menthol is used for treatment of functional dyspepsia in clinical studies. Caraway oil topically on abdomen relieves the IBS symptoms in patient. Although, the use of caraway oil is not recommended in adults under 18 years due to insufficient data, but it can topically use as anti-colic and carminative agent in children or infants. The anti-aflatoxigenic, antioxidant and antimicrobial effects of caraway oil along with its reputation as spice help the industries to use it as natural preservatives and antioxidant agents.

Antimicrobial, Antioxidant, Anti-Acetylcholinesterase, Antidiabetic, and Pharmacokinetic Properties of Carum carvi L. and Coriandrum sativum L. Essential Oils Alone and in Combination

“…Many pharmacological potencies of caraway seeds have been demonstrated such as anti-convulsant, antimicrobial, analgesic, anti-inflammatory, anti-anxiety, anti-hyperglycemic, and anti-spasmodic properties, and it has been used as a cure for dyspepsia, flatulent indigestion, diarrhea, and hysteria [18]. Car-away fruits are used in various traditional systems as curative plants for the management of different ailments, such as digestive disorders, functional dyspepsia, thyroid hormones, as well as a remedy to cure indigestion, pneumonia, carminative, appetizer, and galactagogue [19][20][21]. Also, it has been used as an important ingredient in anti-obesity drugs in Unani traditional medicine [22], largely employed to reduce the plasma triglycerides and cholesterol levels in normal and streptozotocin rats [23].…”

Potent Natural Antioxidant Carveol Attenuates MCAO-Stress Induced Oxidative, Neurodegeneration by Regulating the Nrf-2 Pathway

“…It is found in caraway, mandarin (Citrus reticulata), blackcurrant berries, black tea, and dill (Crowell et al, 1992). The caraway based medicinal plants have been useful in the management of various diseases (Mahboubi, 2019). Carveol has been reported in traditional Chinese medicine as an antispasmodic, carminative, astringent, and further use/used for indigestion and dyspepsia (Sachan et al, 2016).…”

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“…The use of Z. officinale is associated with nausea induced motion sickness and also as appetite stimulant (Yassin et al, 2012). Its constituents namely 6-gingerol and 6-shogaol have been reported for antispasmodic effect via blockade of 5-HT 3 and M 3 receptors in the isolated guinea-pig ileum (Abdel-Aziz et al, 2006).The effectiveness of C. carvi against indigestion accompanied by mild cramps in the GI tract also facilitates in relieving flatulence (Mahboubi, 2019). Its only antipode namely (-)-Carvone has been reported as antispasmodic in guinea pig ileum by reducing contractions induced by histamine, carbachol and BaCl 2 (Souza et al, 2013).…”