Abstract:Resultados de pesquisas confirmaram os atributos medicinais da erva baleeira (Varronia curassavica Jaqc), uma espécie que apresenta metabólicos com propriedades anti-inflamatória e analgésica e que está incluída na lista oficial de plantas medicinais de valor reconhecido pelo Ministério da Saúde brasileiro. Esses constituintes estão presentes nas folhas e ramos que são usados no preparo de chás ou utilizados pela indústria para extração do óleo essencial. O objetivo desse estudo foi caracterizar o crescimento … Show more
“…3930. The area selected for the development of the project corresponded to sub-area 13, at a latitude of 3 • 1.720' S and longitude of 41 • 45.021 W, with dimensions of 3.34 hectares, with the genotype characterized as ID 13 by Lima et al [25], with an average height of 70.66 cm and an average diameter equal to 14.01 mm after one year of planting (Figure 1).…”
Section: Plant Materials and Essential Oil Productionmentioning
Considering the therapeutic potential of Varronia curassavica Jacq. essential oil and the great value in the pharmaceutical market, this study aims to evaluate the influence of plant age on the chemical composition and biological activities of V. curassavica Jacq. essential oil. The plant age is a parameter that can influence the chemical composition of the essential oil, as well as its pharmacological potential. For this purpose, essential oils from aerial parts of V. curassavica produced at different ages (4, 10, 14 and 18 months-age) were used. According to chromatograms obtained by GC-MS, the essential oils were mainly composed of α-pinene, trans-caryophyllene, α-santalene, alloaromadendrene and α-humulene. The chemical composition of V. curassavica essential oils varied qualitatively and quantitatively with the aging of the plants, and the essential oils from plants at 18 month-age appeared to be the most distinct from the others. The tested essential oil samples showed inhibitory activity against Candida albicans (MIC = 1000 µg/mL) but did not show antibacterial activity against the tested bacteria. The cytotoxic activity levels against the murine macrophages varied among the oils extracted from the plants at different ages; the IC50 values of the essential oils increased with age (171.90 µg/mL at 18 month-age). More studies should be carried out to assess whether age also affects the therapeutic effects of essential oils, resulting in the manufacture of plant-derived formulations that balance production costs, toxicity and therapeutic effects.
“…3930. The area selected for the development of the project corresponded to sub-area 13, at a latitude of 3 • 1.720' S and longitude of 41 • 45.021 W, with dimensions of 3.34 hectares, with the genotype characterized as ID 13 by Lima et al [25], with an average height of 70.66 cm and an average diameter equal to 14.01 mm after one year of planting (Figure 1).…”
Section: Plant Materials and Essential Oil Productionmentioning
Considering the therapeutic potential of Varronia curassavica Jacq. essential oil and the great value in the pharmaceutical market, this study aims to evaluate the influence of plant age on the chemical composition and biological activities of V. curassavica Jacq. essential oil. The plant age is a parameter that can influence the chemical composition of the essential oil, as well as its pharmacological potential. For this purpose, essential oils from aerial parts of V. curassavica produced at different ages (4, 10, 14 and 18 months-age) were used. According to chromatograms obtained by GC-MS, the essential oils were mainly composed of α-pinene, trans-caryophyllene, α-santalene, alloaromadendrene and α-humulene. The chemical composition of V. curassavica essential oils varied qualitatively and quantitatively with the aging of the plants, and the essential oils from plants at 18 month-age appeared to be the most distinct from the others. The tested essential oil samples showed inhibitory activity against Candida albicans (MIC = 1000 µg/mL) but did not show antibacterial activity against the tested bacteria. The cytotoxic activity levels against the murine macrophages varied among the oils extracted from the plants at different ages; the IC50 values of the essential oils increased with age (171.90 µg/mL at 18 month-age). More studies should be carried out to assess whether age also affects the therapeutic effects of essential oils, resulting in the manufacture of plant-derived formulations that balance production costs, toxicity and therapeutic effects.
“…A espécie Varronia curassavica Jaqc., popularmente conhecida como erva-baleeira, é nativa da Mata Atlântica e está presente em todo o Brasil. Essa planta é utilizada na medicina tradicional como analgésica, anti-inflamatória e antiulcerogênica (LIMA et al, 2021). No entanto, há falta de estudos sobre o efeito do floral de V. curassavica na dor.…”
A busca por tratamentos naturais e o uso da medicina complementar e integrativa tem aumentado nas últimas décadas, incluindo florais. Estudos sobre o uso de florais no tratamento contra a dor são escassos, especialmente em relação ao floral de Varronia curassavica. Portanto, o presente estudo investigou os efeitos antinociceptivos do floral de V. curassavica após tratamento contínuo por 21 dias em camundongos. Camundongos Mus musculus machos (n=8 animais/grupo) foram divididos em quatro grupos: grupo 1 (naïve), grupo 2 (floral), grupo 3 (veículo) e grupo 4 (controle positivo – morfina). O grupo floral recebeu uma dose oral diária de 0,45 mL de floral de V. curassavica por 21 dias consecutivos no mesmo horário do dia. Observaram-se os efeitos antinociceptivos do floral nos modelos experimentais de formalina, contorções abdominais induzidas por ácido acético e placa quente. Comparado ao grupo veículo, o floral de V. curassavica reduziu as duas fases da nocicepção induzida pela injeção intraplantar de formalina em aproximadamente 27% e 31%, respectivamente, reduziu o número de contorções abdominais em resposta à nocicepção induzida por ácido acético em aproximadamente 47% e resultou em aumento significativo do tempo da latência para retirada de pata frente a estímulo térmico induzido por placa quente em mais de 90%. Em suma, o floral de V. curassavica gerou efeito antinociceptivo frente a estímulos térmicos e químicos em camundongos.
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