Objective: To analyze factors associated with the occurrence of Adverse Events (AE) related to the Peripherally Inserted Central Catheter (PICC) in Newborns (NB). Method: cross-sectional, descriptive and analytical study, carried out in the Neonatal Intensive Care Unit of a reference hospital, from January to March 2019. The sample consisted of 225 PICCs. The occurrence of AEs was considered as an outcome, and the hierarchical variables were considered explanatory: distal (sociodemographic) and proximal (NB clinics). Wald's chi-square was used for the initial selection of variables (p<0.20) and Poisson regression, with robust variance, for model adjustment (p<0.05). The t test was used to compare the mean occurrence of AE with the insertion of the PICC, at the 5% level. In the final model, the insertion site, scalp vein (p<0.001), and reason for removal (p<0.001) of the PICC were significant for the occurrence of AE. Comparing the averages between occurrences and non-occurrences of AEs, it was verified that only the weight of the NBs was significant (p=0.002), due to prematurity. Conclusion: AEs are related to inadequate management of PICC maintenance and choice of vein.