Caracterização da função das células TCD4+ e TCD8+ na Paracoccidioidomicose pulmonar de camundongos isogênicos

Chiarella, Andressa de Paiva

doi:10.11606/d.9.2003.tde-05032015-150715

Cited by 1 publication

(2 citation statements)

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“…Unpublished results from our laboratory suggest that increased and sustained expression of IP-10, RAN-TES and the chemokine receptor CXCR3 is associated with the resistant behavior of A/Sn mice (C. Arruda and V. L. G. Calich, unpublished observations). This is in accordance with the sustained T cell response mounted by resistant mice at the acquired phase of the immune response [14,15].…”

Section: Genetic Control Of Susceptibilitysupporting

confidence: 83%

“…Accordingly, from week 8 of infection onward, positive DTH responses, marked control of fungal burdens, secretion of pulmonary type 1 and type 2 cytokines and preferential production of IgG2a antibodies were seen, leading to a regressive pattern of disease. On the contrary, the anergy of DTH reactions, the preferential synthesis of IgG1 and IgG2b antibodies and the progressively increased fungal burdens of susceptible mice resulted in severe disseminated disease leading to decreased survival times [14,15].…”

Section: The Isogenic Murine Model Of Resistance/ Susceptibility Of Pmentioning

confidence: 99%

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Innate immunity to Paracoccidioides brasiliensis infection

et al. 2008

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Innate immunity is based in pre-existing elements of the immune system that directly interact with all types of microbes leading to their destruction or growth inhibition. Several elements of this early defense mechanism act in concert to control initial pathogen growth and have profound effect on the adaptative immune response that further develops. Although most studies in paracoccidioidomycosis have been dedicated to understand cellular and humoral immune responses, innate immunity remains poorly defined. Hence, the main purpose of this review is to present and discuss some mechanisms of innate immunity developed by resistant and susceptible mice to Paracoccidioides brasiliensis infection, trying to understand how this initial host-pathogen interface interferes with the protective or deleterious adaptative immune response that will dictate disease outcome. An analysis of some mechanisms and mediators of innate immunity such as the activation of complement proteins, the microbicidal activity of natural killer cells and phagocytes, the production of inflammatory eicosanoids, cytokines, and chemokines among others, is presented trying to show the important role played by innate immunity in the host response to P. brasiliensis infection.

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Section: Genetic Control Of Susceptibilitysupporting

confidence: 83%

Section: The Isogenic Murine Model Of Resistance/ Susceptibility Of Pmentioning

confidence: 99%