Caractéristiques du lupus érythémateux systémique à La Réunion : étude rétrospective en population adulte au CHU de Saint-Denis

Gaüzère, L.; Gerber, Andreas; Renou, F.; Ferrándiz, Daniel Álvarez; Bagny, K.; Osdoit, S.; Yvin, J.-L.; Raffray, L.

doi:10.1016/j.revmed.2018.07.004

Cited by 6 publications

(2 citation statements)

References 21 publications

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“…В то время как в возникновении и развитии СКВ важную роль играют эстрогены, ДКВ считается эстроген-независимой патологией. Так, соотношение женщин и мужчин репродуктивного возраста с ДКВ состав- (8)(9)(10)(11)(12)(13)(14)(15):1 при СКВ [2]. Воздействие излучения УФ-В (длина волны 290-320 нм) и УФ-А2 (длина волны 320-340 нм) вызывает и усугубляет повреждение кожи как при СКВ, так и при ДКВ [2].…”

Section: Introductionunclassified

Comparative characteristics of blood xanthine oxidoreductase profiles in discoid and systemic lupus erythematosus

Mozgovaya,

Bedina,

Trofimenko

et al. 2024

Sibirskij nauchnyj medicinskij zhurnal

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Discoid (DLE) and systemic lupus erythematosus (SLE) are chronic inflammatory diseases of the connective tissue. Along with pathogenetic features, they have common characteristics. Immune disorders and oxidative stress are involved in pathogenesis of DLE and SLE. Development of oxidative stress is closely associated with the activation of xanthine oxidoreductase (XOR) enzyme system.Aim of the study was to reveal the features of XOR activities profiles in blood of DLE and systemic lupus erythematosus (SLE) patients.Material and methods. 31 patients with DLE, 56 patients with SLE, 35 apparently healthy individuals were enrolled in study. The activities of two convertible forms of XOR (xanthine dehydrogenase (XDG; EC 1.17.1.4) and xanthine oxidase (XO; EC 1.17.3.2)) were measured in plasma, lysed WBC and lysed RBC. The level of uric acid (UA) was determined in plasma.Results and discussion. In contrast to the control, XO activity was higher and XDG activity was lower in plasma of DLE patients; activities of both XOR forms were decreased in lysed lymphocytes. Activity of XO was lower in plasma, XO and XDG activities were higher in lysed lymphocytes in DLE regardless of the SLE activity. XDG activity in plasma of and XO activity in lysed erythrocytes DLE patients was lower than in low activity SLE, but higher than in the subgroup with moderate and high disease activity. XDG activity of lysed erythrocytes in DLE was higher than in patients with low and moderate SLE activities, but lower than in patients with high diseases activity. Uric acid content in plasma of DLE patients was not differ from the control values, its level was increased at II and III degrees of SLE activity.Conclusions. Changes in XOR activity in plasma and lysed WBC in DLE and SLE are unidirectional, but are more pronounced in the systemic form of the disease. Thus, DLE and SLE are characterized by some common changes in XOR activity, at the same time, XOR blood profiles have distinctive features, which are characteristic for nosology.

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Section: Introductionunclassified

Comparative characteristics of blood xanthine oxidoreductase profiles in discoid and systemic lupus erythematosus

Mozgovaya,

Bedina,

Trofimenko

et al. 2024

Sibirskij nauchnyj medicinskij zhurnal

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“…SLE is a chronic, multisystem inflammatory disease that predominantly affects young women 13 . The prevalence of SLE ranges between 2% and 15% 14 . SSc is a rare chronic disease of unknown cause characterized by diffuse fibrosis and vascular abnormalities of the skin, joints, and internal organs.…”

Section: Introductionmentioning

confidence: 99%

Outcomes of hemorrhagic stroke in patients with autoimmune rheumatic diseases: An analysis of the US Nationwide Inpatient Sample

Chen,

Chang

et al. 2023

Int J of Rheum Dis

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AimTo determine whether and how rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and systemic sclerosis (SSc) affect outcomes in patients admitted for hemorrhagic stroke.MethodsThis study screened the Nationwide Inpatient Sample database for adults aged ≥20 years admitted to US hospitals with a principal diagnosis of intracerebral hemorrhage (ICH) between 2005 and 2018. Diagnoses were determined using the International Classification of Diseases, 9th and 10th revisions (ICD‐9 and ICD‐10) diagnostic codes for ICH (ICD‐9: 431, 432; ICD‐10: I61, I62). Study outcomes were: (1) in‐hospital mortality; (2) unfavorable discharge, defined as transfer to nursing homes or long‐term care facilities; and (3) prolonged length of stay (LOS), defined as LOS >75th centile.ResultsAssociations between comorbid RA, SLE, and SSc and clinical outcomes show a significantly lower risk of in‐hospital mortality and prolonged LOS in RA patients. After admissions for ICH, the risk for in‐hospital mortality and prolonged LOS was decreased in RA patients, and the risk for unfavorable discharge (long‐term care) was reduced in SLE patients.ConclusionsAmong patients admitted to US hospitals for hemorrhagic stroke, patients with RA had decreased risk for in‐hospital mortality and prolonged LOS.

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A Case of Alopecia

Ergen

Karabulut

Türsen

2022

Clinical Cases in Hair Disorders

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Caractéristiques du lupus érythémateux systémique à La Réunion : étude rétrospective en population adulte au CHU de Saint-Denis

Cited by 6 publications

References 21 publications

Comparative characteristics of blood xanthine oxidoreductase profiles in discoid and systemic lupus erythematosus

Comparative characteristics of blood xanthine oxidoreductase profiles in discoid and systemic lupus erythematosus

Outcomes of hemorrhagic stroke in patients with autoimmune rheumatic diseases: An analysis of the US Nationwide Inpatient Sample

A Case of Alopecia

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