Caractéristiques de la leucémie lymphoïde chronique au Togo

Padaro, E; Layibo, Yao; Kueviakoe, Irénée Délagnon Messanh; Agbetiafa, Kossi; Magnang, Hézouwè; Koudokpo, Nicole Delali Akossiwa; Mawussi, Koffi; Vovor, A.

doi:10.11604/pamj.2019.34.84.18752

Cited by 5 publications

(8 citation statements)

References 21 publications

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“…Thirteen (13) cases of hemophilia out of 5995 people selected (0.22%) have been detected with a mean age of 14.85 (1.5-49). Previous studies in Cameroon, Ivory Coast, Senegal and South Africa also found a similar age [5,8,10,13,14]. The young age is usually the period of diagnosis of the disease.…”

Section: Discussionmentioning

confidence: 58%

“…However, the mean age of patients at diagnosis was higher than the age of onset of abnormal bleeding, suggesting the delay of subjects to attend the; which suggests that patients do not immediately go to a This information suggests that the hemophilia had long been ignored, thus considered as a ''now-adays disease''. All cases of hemophilia reported in this study were male, owing to its recessive sex-related transmissibility, thus being rare in African women [10,13,15,16]. However, women carrying the abnormal gene may have a mild or moderate factor VIII or IX deficiency and may suffer from bleeding disorders, particularly gynecological or obstetric [16].…”

Section: Discussionmentioning

confidence: 86%

“…The main report circumstances were bleeding during circumcision in the months following birth (69%), and traumatic wounds in the childhood. In 2017, Padaro et al in Togo also found circumcision as the first circumstances of discovery of hemophilia [13]. However, the mean age of patients at diagnosis was higher than the age of onset of abnormal bleeding, suggesting the delay of subjects to attend the; which suggests that patients do not immediately go to a This information suggests that the hemophilia had long been ignored, thus considered as a ''now-adays disease''.…”

Section: Discussionmentioning

confidence: 99%

“…The level of education of hemophiliac subjects reveals that 77% have a primary or secondary level. Any difference is not pointed out from children of the same age group in the general population [13,17,18]. Tayou et al in 2014 showed a level of education between primary and secondary level.…”

Section: Discussionmentioning

confidence: 99%

“…A family antecedents of hemophilia was common (up to 66% of cases) as in Senegal and in the study by Tayou et al During the present study, male circumcision was the main diagnostic circumstance, followed by mucosal bleeding. Haemarthrosis and joint complications have been found in almost all patients as well as in studies conducted in other African countries (Ivory Coast, Western Cape, Senegal and South Africa) [10,13,17,18]. Biological analyzes carried out using the SOCIMED model AG04 coagulometer whose chronometric measurement principle is based on the use of ARM meaning to measure the speed of the magnetic ball in order to calculate the coagulation time.…”

Section: Discussionmentioning

confidence: 99%

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Prevalence and Clinical Aspects of Hemophilia in the Western Region of Cameroon

Tuono

Tazemda-Kuitsouc²,

Tambo³

et al. 2022

IBRR

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Introduction: Hemophilia is a constitutional defect in blood clotting related to a clotting factor deficiency. Its remains a major public health problem, mainly due to ignorance of the disease, limited screening capacities and access to treatment in sub-Saharan Africa and particularly in Cameroon. It causes heavy bleeding in the absence of adequate management. Few reports are available about the disease in countries with limited resources. This study assess the occurrence of hemophilia in the Western region of Cameroon and clinical aspects with the aim of raising public awareness of the disease. Methods: A cross-sectional and descriptive study was carried out over a period of 04 months in 5 departments of the Western region of Cameroon, in particular Mifi, Ndé, Bamboutos, Haut Nkam and Menoua. The individuals were selected in their houses on the basis of clinical arguments, i.e. bleeding from the gums, traumatic wounds, hematomas. The blood samples taken from the latter were analyzed in the hemostasis laboratory of the Regional Hospital of Bafoussam. The epidemiological characteristics of hemophiliacs identified and suspects hemophiliacs were analyzed. The results obtained were analysed using statistical software R version 4.1.1. Results: Out of 5995 people selected, 13 (0.22%) cases of hemophilia were identified, 09 confirmed cases and 04 new cases. The mean age of the patients was 14.85 years old (1.5-49). The disease was discovered mainly during circumcision in the months following birth (9/13, 69.23%), and by bleeding of the gums (9/13, 69.23%). Clinical signs were pain of the joints (46%), hematoma and swelling of the joints (38%). Platelets counts and prothrombin rate were normal in all. However, a prolonged Cephalin + Activator Time was found; it was corrected by supplying normal control plasma. Conclusion: Hemophilia is a pathology little known for the general public. For this, with the help of public authorithies, continuing education sessions must be set up to raise awareness among the population in order to limit the transmission of the disease and to eradicate this scourge which constitutes a real public health problem.

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Section: Discussionmentioning

confidence: 58%

Section: Discussionmentioning

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Prevalence and Clinical Aspects of Hemophilia in the Western Region of Cameroon

Tuono

Tazemda-Kuitsouc²,

Tambo³

et al. 2022

IBRR

View full text Add to dashboard Cite

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Study of immunophenotypic markers and clinico-hematological findings in chronic lymphocytic leukemia

Mazin Butrous,

Sadiq Muhammad

2023

Zanco J Med Sci

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Background and objective: Chronic lymphocytic leukemia (CLL) is a clonal, mature B-cell neoplasm, its clinical features, cell morphology, and immunophenotyping are used to establish the diagnosis. Immunophenotyping by flow cytometry is the most accurate procedure for diagnosing CLL, there is no single marker exclusively expressed in CLL, however, a complex of immunophenotypic markers that incorporates several B-cell markers and assists in differentiating CLL from other mature B-cell neoplasms, the expression of these immunophenotypic markers is considered in the specific CLL scoring system (Moreue scoring system).this study aimed to assess the clinico – hematological features and immunophenotypic characteristics of CLL patients and to assess the role of immunophenotyping in the differential diagnosis of CLL. Methods: an observational prospective and retrospective study was carried out at Nanakaly hospital for blood diseases and oncology in Erbil city, Iraq. That was conducted on 100 patients newly diagnosed with mature B cell neoplasm which included 68 cases of CLL and 32 cases with other mature B cell neoplasm (MBN), usinga convenience sampling method. The study period was from the1st of September 2021 to the end of April 2022. An interview questionnaire was used to collect the study data from the patients. Results: The mean of age ± standard deviation of the CLL patients (58.85 ± 10.69) years and (66.2%) was male, The most frequent clinical presentations for CLL cases were fatigue (50%), lymphadenopathy (41.2%), and splenomegaly (41.2%), (50%) of CLL patients had anemia, thrombocytopenia was seen in (32.4%) and leukocytosis was seen (98.5%), all patients had lymphocytosis and (97%) had an absolute B lymphocyte count of more than 5 x109 /L. all the studied CLL patients expressed both CD45 and CD19 markers, the expression of the immunophenotypic markers was as following: CD5 (98.5%), CD23 (97.1%) and CD200 (97.1%), Half of the patients (50%) showed expression of monoclonal lambda light chain, sIgM (4.4%), CD20 (88.2%) and CD43 (54.4%) and CD38 (26.5%). The expression of the following marker had a significant role in the differentiation between CLL and other MBN: CD5, CD23, CD79b, FMC7, sIgM, CD200, and CD43. Conclusion: Our results have shown that the clinical presentations and hematological profile of Iraqi CLL patients were not significantly different from that of previous local and global studies, the distinct immunophenotyping, as well as it has been found that immunophenotyping is a promising method for supporting the clinical and morphological characterization of CLL.

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Lymphocytic Lymphoma Transforming into Hodgkin Lymphoma in Sub-Saharan Africa: Case Report and Literature Review

Touré,

Niang,

Gueye

et al. 2024

Hematology Reports

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The Hodgkin variant Richter syndrome (HvRS) is an infrequent complication occurring in 1% of lymphocytic lymphoma/chronic lymphocytic leukemia patients. We report a case of HvRS diagnosed in Sub-Saharan Africa. A 63-year-old patient was consulted for the investigation of an abdominal mass that had been evolving for 5 years prior to admission. His history revealed night sweats, 13% weight loss in 3 months and persistent pruritis. Examination revealed bilateral cervical axillary and inguinal macroadenopathies, painless abdominal distension, pruritic lesions and WHO 2 PS. The blood count showed anemia at 9.5 g/dL. Histology revealed a lymphomatous proliferation of diffuse architecture, nodular in places, with Hodgkin and Sternberg cells associated with small lymphocytes, histiocytes and eosinophilic polymorphs. Immunohistochemistry showed CD20, PAX5, BCL2, CD5, CD23 and MYC positivity; Ki67 at 10% and cyclin D1, BCL6 and CD10 negativity; CD30 positivity on Hodgkin and Sternberg cells that remained CD20 negative; difficulty interpreting CD15; EBV positivity (EBERs); and CD3 and CD5 positivity on reactive T cells. CD138 and kappa and lambda light chains were non-contributory. The extension work-up classified the patient as Ann Arbor stage III B with a Hasenclever score of 3/7. This case illustrates the difficulties in diagnosing HvRS in our countries, where the number of haematopathologists is insufficient and the technical facilities are limited.

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Caractéristiques de la leucémie lymphoïde chronique au Togo

Cited by 5 publications

References 21 publications

Prevalence and Clinical Aspects of Hemophilia in the Western Region of Cameroon

Prevalence and Clinical Aspects of Hemophilia in the Western Region of Cameroon

Study of immunophenotypic markers and clinico-hematological findings in chronic lymphocytic leukemia

Lymphocytic Lymphoma Transforming into Hodgkin Lymphoma in Sub-Saharan Africa: Case Report and Literature Review

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