Características y tipos de agonistas del receptor de GLP-1. Una oportunidad más para la individualización terapéutica

Jódar, Esteban

doi:10.1016/s0025-7753(14)70103-4

Cited by 1 publication

(1 citation statement)

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“…Interestingly, within the drugs tested were other GLP-1RAs such as exenatide or liraglutide. It would thus appear that the molecular, pharmacokinetic and pharmacodynamic differences in these drugs could influence the anti-inflammatory effect ( 61 ).…”

Section: Discussionmentioning

confidence: 99%

Anti-inflammatory effect of semaglutide: updated systematic review and meta-analysis

Masson,

Lobo,

Nogueira

et al. 2024

Front. Cardiovasc. Med.

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BackgroundThe anti-inflammatory effect could be one of the mechanisms by which semaglutide reduces cardiovascular risk in patients with type 2 diabetes mellitus (T2DM) and/or obesity. Determining the anti-inflammatory effect of semaglutide was the objective of this systematic review and meta-analysis.MethodsThis meta-analysis was performed according to the PRISMA guidelines. A literature search was performed to detect randomised clinical trials that have quantified the effect of semaglutide on C-reactive protein (CRP) levels compared to placebo or a control group (other glucose-lowering drugs). The primary outcome was CRP index (final CRP/basal CRP). A random-effects model was used.ResultsThirteen randomised clinical trials were considered eligible (n = 26,131). Overall, semaglutide therapy was associated with lower CRP index values compared to the placebo group (SMD −0.56; 95% CI −0.69 to −0.43, I2 92%) or the control group (SMD −0.45; 95% CI −0.68 to −0.23, I2 82%).Such an association was similarly observed when different treatment regimens (subcutaneous vs. oral) or different populations (patients with or without T2DM) were analysed. The sensitivity analysis showed that the results were robust.ConclusionThe present meta-analysis demonstrated that the use of semaglutide was associated with a reduction in inflammation irrespective of the population evaluated or the treatment regimen used. These findings would explain one of the mechanisms by which semaglutide reduces cardiovascular events.Systematic Review RegistrationPROSPERO [CRD42024500551].

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Section: Discussionmentioning

confidence: 99%