Características fenotípicas de los pacientes con síndrome de poliposis serrada de colon: estudio de 23 casos

Elorza, Garazi; Enríquez-Navascués, José María; Bujanda, Luís; Larzábal, Mikel; Lasa, Inés Gil; Martí, Laura

doi:10.1016/j.ciresp.2014.02.005

Cited by 3 publications

(2 citation statements)

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“…Only a few reports have addressed the prevalence of SPS. In Western studies, the prevalence of SPS was 0.08% to 0.66% 181920. One Korean study also reported the prevalence of SPS as 0.06% 29.…”

Section: Discussionmentioning

confidence: 98%

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Clinical characteristics of patients with serrated polyposis syndrome in Korea: comparison with Western patients

et al. 2017

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Background/AimsSerrated polyposis syndrome (SPS) has been shown to increase the risk of colorectal cancer (CRC). However, little is known about the characteristics of Asian patients with SPS. This study aimed to identify the clinicopathological features and risk of CRC in Korean patients with SPS as well as the differences between Korean and Western patients based on a literature review.MethodsThis retrospective study included 30 patients with SPS as defined by World Health Organization classification treated at Samsung Medical Center, Korea, between March 1999 and May 2011.ResultsTwenty patients (67%) were male. The median patient age at diagnosis was 56 years (range, 39–76 years). A total of 702 polyps were identified during a median follow-up of 43 months (range, 0–149 months). Serrated polyps were noted more frequently in the distal colon (298/702, 55%). However, large serrated polyps and serrated adenomas were mainly distributed throughout the proximal colon (75% vs. 25% and 81% vs. 19%, respectively); 73.3% had synchronous adenomatous polyps. The incidence of CRC was 10% (3/30 patients), but no interval CRC was detected. A total of 87% of the patients underwent esophagogastroduodenoscopy and 19.2% had significant lesions.ConclusionsThe phenotype of SPS in Korean patients is different from that of Western patients. In Korean patients, SPS is more common in men, there were fewer total numbers of serrated adenoma/polyps, and the incidence of CRC was lower than that in Western patients. Korean patients tend to more frequently have abnormal gastric lesions. However, the prevalence of synchronous adenomatous polyps is high in both Western and Korean patients.

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Section: Discussionmentioning

confidence: 98%

“…Although previous studies reported various types of extracolonic malignancies, data supporting an association between SP and extracolonic tumor risk is lacking 319252629…”

Section: Discussionmentioning

confidence: 99%