Características clínicas y factores asociados a mortalidad en pacientes adultos hospitalizados por COVID-19 en un hospital público de Lima, Perú.

Cordero, Fernando Alonso Mejía; Medina, Carlos Rubio; Cornejo, E; Morello, Enrique; Vásquez, Sergio; Alave, Jorge; Schwalb, Alvaro; Málaga, Germán

doi:10.1590/scielopreprints.858

Cited by 26 publications

(35 citation statements)

References 24 publications

(32 reference statements)

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“…Later, the supply of oxygen proved to be largely insufficient in public health facilities in the interior of the country as they did not have oxygen plants, which led people to decide to manage their family members at home, acquiring oxygen from private providers combined with the exaggerated increase in the cost of this service, so many families could not afford it. It should be noted that a study carried out in a hospital in Lima 32 found that oxygen saturation less than 85% was the main predictor of death in people with COVID-19 pneumonia.…”

Section: Discussionmentioning

confidence: 96%

Epidemiological characteristics of deaths from COVID-19: an analysis at almost three months of the first confirmed case in Peru

Ramos

Arrasco

Cruz-Vargas

et al. 2020

Preprint

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OBJECTIVE: To determine the epidemiological characteristics of deaths from COVID-19 in Peru from March 28 to May 21, 2020, 85 days after the report of the first confirmed case. MATERIAL AND METHODS: Case series type study. Deaths from various sources were investigated, including the COVID-19 Epidemiological Surveillance and the National System of Deaths. Deaths that met the definition of a confirmed case and had a positive (reactive) result of RT-PCR or rapid test were considered for the analysis. From these sources, epidemiological variables were obtained and a time analysis was performed, defining as the pre-hospital time the time from the onset of symptoms to the date of hospitalization and hospital time from the date of hospitalization to the date of death. RESULTS: 3,244 confirmed deaths were included in the study. Deaths were more frequent in males (71.8%), elders (68.3%), residents of the department of Lima (41.8%), and others from the coast (37.7%). In 81.3% of cases, the death occurred in a public hospital, 16.0% died at home, shelter, penitentiary institution, public highway, or in transit to a hospital, and 31.1% had some comorbidity. Statistical difference was observed in pre-hospital time according to age group (p <0.001) and gender (p = 0.037), being significantly higher in adults, elders, and women. There was a statistically significant difference in hospital time according to geographic area, showing a significantly shorter time in the departments of the coast (p <0.001) and Andean region (p = 0.014) compared to Lima. The cases that were seen in private clinics (p = 0.001) survived longer than those seen in public hospitals. CONCLUSION: Deaths from COVID-19 occur mainly in male, elders, on the coast, with considerable deaths at home, in shelters, penitentiaries, public roads, or in transit to a hospital. Pre-hospital time is affected by age group and gender; while, hospital time is also influenced by the region of origin and the health care provider. KEYWORDS: Coronavirus, COVID-19, deaths, epidemiology, Peru.

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Section: Discussionmentioning

confidence: 96%

Epidemiological characteristics of deaths from COVID-19: an analysis at almost three months of the first confirmed case in Peru

Ramos

Arrasco

Cruz-Vargas

et al. 2020

Preprint

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“…La principal comorbilidad fue la obesidad, seguida de la hipertensión arterial y la diabetes mellitus, que constituyeron las patologías crónicas prevalentes en el país. Estas comorbilidades son similares a los referidos por Mejía y colaboradores en Perú (24) y por Villagrán y colaboradores en México (19) . Las personas con obesidad tienen más riesgo de desarrollar formas graves por coronavirus (25,26) .…”

Section: Discussionunclassified

Clinical characteristics of the first 60 patients with SARS CoV-2 admitted to the National Hospital for the period June-August 2020

Sobarzo

López²,

Serra

et al. 2021

Rev. virtual Soc. Parag. Med. Int

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Introducción: las manifestaciones clínicas del SARS CoV-2 se caracterizan por varios síntomas como fiebre, tos, disnea, mialgia, fatiga, diarrea y trastorno del olfato/gusto, como también existen casos asintomáticos.Objetivos: determinar las características clínicas: datos demográficos, síntomas mas frecuentes, comorbilidades y evolución, de los primeros 60 pacientes con SARS CoV-2 internados en el Hospital Nacional (Itauguá, Paraguay) en el periodo junio-agosto, 2020.Metodología: estudio observacional descriptivo prospectivo, no probabilístico de casos consecutivos. Se incluyó a pacientes varones y mujeres, mayores de 18 años de edad, portadores de SARS CoV-2, internados en el Hospital Nacional en el periodo junio-agosto, 2020. Se midieron variables clínicas y sociodemográficas. Se respetaron los aspectos éticos.Resultados: se incluyeron 60 pacientes con edad media 44±16 años y siendo 52% del sexo masculino, en su mayoría procedentes del Departamento Central. Entre los síntomas predominó la disnea (27%). La comorbilidad más frecuente fue la obesidad (40%). La mortalidad de los pacientes internados fue 5%.Conclusión: en la muestra predominaron los adultos jóvenes y del sexo masculino (52%). El síntoma más frecuente fue la disnea (27%) y la comorbilidad prevaleciente fue la obesidad (40%). La mortalidad fue 5%.

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“…Mejia et al 2020 published the only available study similar to ours in a cohort of Peruvian patients. They found that the median age of the admitted patients was 59 years [17]. Although there is no clear information on why older men are at higher risk of dying due to COVID-19, a higher proportion of comorbidities among men may play a signi cant role, and the presence of unhealthier lifestyles.…”

Section: Discussionmentioning

confidence: 99%

Predicting mortality in critically ill COVID-19 patients in a low-resources setting

Páez¹,

Montalvo²,

Jara³

et al. 2021

Preprint

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Background Since its molecular isolation on January 7, 2020, the novel coronavirus SARS-CoV-2 has spread rapidly, taking governments worldwide off-guard. The virus arrived in low and middle-income countries violently, especially in Latin America. Ecuador received the worst outbreak in the world if we count excess mortality per capita. Although one study has reported the epidemiological impact of COVID-19 in Ecuador, there is no clinical course or outcome data among intensive care patients with COVID-19 in Ecuador. This study describes the clinical, epidemiological, and therapeutical features of 89 patients hospitalized in a secondary-level hospital in Quito, Ecuador. Methods We did a retrospective cohort study. We collected health records data from adult patients with severe COVID-19 admitted to the intensive care unit (ICU) in Quito, Ecuador, during the first five months of the SARS-CoV-2 outbreak in Ecuador. All patients had a confirmed SARS-CoV-2 RNA infection diagnostic, a positive real-time RT-PCR, and pulmonary imaging suggesting COVID-19. We used the Chi-square test or a Fisher's exact statistic to analyze risk and associations between survivors and non-survivors due to COVID-19. We used the ROC curve analysis to predict mortality, determining cut-off points for the parameters related to mechanical, analytical, and cytometry ventilation. At the multivariate level, we used the Wald test to evaluate model categorical predictors during the regression analysis. Results 89 patients with COVID-19 were recruited during the study. The average age of the patients was 54.72 years. Man represented 68.54% (n = 61) and women 31,46% (n = 28). Significant differences were observed in terms of mortality (men 40.98% vs. women 17.76%). Serological parameters demonstrated that LDH and IL-6 at 24 hours were higher among non-survivors when compared with survivors. Persistent hypercapnia ( > > 45 mmHg), a PaFiO2 ratio of less than 140 mmHg, and a positive end-expiratory pressure (PEEP) titration greater than nine mmHg were also associated with higher mortality. Conclusions Increased levels of LDH at 24 hours, IL-6, the lymphocyte and platelet count at 48 hours, the neutrophil count at 48 hours, and the INL are factors associated with higher motility, increased risk of failed extubation and reintubation

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Características clínicas y factores asociados a mortalidad en pacientes adultos hospitalizados por COVID-19 en un hospital público de Lima, Perú.

Cited by 26 publications

References 24 publications

Epidemiological characteristics of deaths from COVID-19: an analysis at almost three months of the first confirmed case in Peru

Epidemiological characteristics of deaths from COVID-19: an analysis at almost three months of the first confirmed case in Peru

Clinical characteristics of the first 60 patients with SARS CoV-2 admitted to the National Hospital for the period June-August 2020

Predicting mortality in critically ill COVID-19 patients in a low-resources setting

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