CAR Treg synergy with anti-CD154 mediates infectious tolerance to dictate heart transplant outcomes.
Samarth S Durgam,
Isaac Rosado sanchez,
Dengping Yin
et al.
Abstract:The ability to induce allograft specific tolerance would reduce the need for daily pharmacological immunosuppression, improve post-transplant quality of life and transplant outcomes. Adoptive cell therapy with regulatory T cells expressing donor-specific Chimeric Antigen Receptors (CAR-Tregs) is a promising strategy, but monotherapy has not resulted in prolonged survival of grafts with multiple MHC mismatches. We used a clinically-relevant, haplo-mismatched model of heart transplantation in immune-competent C5… Show more
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