CAR-T cells SEAK help from enzymes

Vincent, Rosa L.; Danino, Tal

doi:10.1038/s41589-021-00933-0

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Rational Designs Of Car-t Therapy For Solid Tumor Treatment1

Car-t-based Cellular Immunotherapy1

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2023

2024

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Cited by 4 publications

(2 citation statements)

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“…(B) Schematic illustration of SEAKER cells which can locally activate chemotherapeutic prodrugs to eliminate antigen-negative tumor cells. Reproduced with permission [ 98 ]. …”

Section: Rational Designs Of Car-t Therapy For Solid Tumor Treatmentmentioning

confidence: 99%

Rationally designed approaches to augment CAR-T therapy for solid tumor treatment

Zhu,

Wu,

Sheng

et al. 2024

Bioactive Materials

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“…(B) Schematic illustration of SEAKER cells which can locally activate chemotherapeutic prodrugs to eliminate antigen-negative tumor cells. Reproduced with permission [ 98 ]. …”

Section: Rational Designs Of Car-t Therapy For Solid Tumor Treatmentmentioning

confidence: 99%

Rationally designed approaches to augment CAR-T therapy for solid tumor treatment

Zhu,

Wu,

Sheng

et al. 2024

Bioactive Materials

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“…153,154 Engineered CAR-T cells can secrete extracellular cytokines (including IL-12, 155 IL-15, 156 and IL-18 157 ), antibodies, and bacterial enzymes increasing the prodrug concentration at the disease site. 158 C. perfringens neuraminidase (CpNA) can remove sialic acid residues from the target cells. CpNA-restrained CAR-T cells exhibited superior effector function and cytotoxicity in vitro, showing enhanced antitumor efficacy in a Nalm-6 xenograft model of leukemia, xenograft model of glioblastoma, and syngeneic model of melanoma.…”

Section: Car-t-based Cellular Immunotherapymentioning

confidence: 99%

Synthetic biology-inspired cell engineering in diagnosis, treatment and drug development

Zhao

Song

Xie

et al. 2023

Sig Transduct Target Ther

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The fast-developing synthetic biology (SB) has provided many genetic tools to reprogram and engineer cells for improved performance, novel functions, and diverse applications. Such cell engineering resources can play a critical role in the research and development of novel therapeutics. However, there are certain limitations and challenges in applying genetically engineered cells in clinical practice. This literature review updates the recent advances in biomedical applications, including diagnosis, treatment, and drug development, of SB-inspired cell engineering. It describes technologies and relevant examples in a clinical and experimental setup that may significantly impact the biomedicine field. At last, this review concludes the results with future directions to optimize the performances of synthetic gene circuits to regulate the therapeutic activities of cell-based tools in specific diseases.

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Cell-based relay delivery strategy in biomedical applications

Chen

Pal

2023

Advanced Drug Delivery Reviews

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CAR-T cells SEAK help from enzymes

Cited by 4 publications

References 10 publications

Rationally designed approaches to augment CAR-T therapy for solid tumor treatment

Rationally designed approaches to augment CAR-T therapy for solid tumor treatment

Synthetic biology-inspired cell engineering in diagnosis, treatment and drug development

Cell-based relay delivery strategy in biomedical applications

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