CAR T-cell toxicities: from bedside to bench, how novel toxicities inform laboratory investigations
Fabiana Perna,
Samir Parekh,
Caroline Diorio
et al.
Abstract:Multiple chimeric antigen receptor (CAR) T cell therapies are FDA approved, and several are under development. While effective for some cancers, toxicities remain a limitation. The most common toxicities, i.e. cytokine release syndrome (CRS) and immune effector cell associated neurotoxicity syndrome (ICANS), are well described. With increasing utilization, providers worldwide are reporting on other emergent, and often complicated toxicities. Given the evolving toxicity profiles and urgent need to catalogue the… Show more
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