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Pharmacokinetics and tissue concentrations of azithromycin in ball pythons ( Python regius )

“…Aeromonas hydrophila is 1 of the most common reptile pathogens, especially in infections of the respiratory tract and in cases of stomatitis. 29 The minimum inhibitory concentration that will result in death of 90% of the organisms (MIC 90 ) of azithromycin for A hydrophila is 4 µg/mL. 30 In our study, the concentration of azithromycin in skin specimens was slightly less than the reported MIC 90 for A hydrophila at 24 hours after administration and much lower at 72 hours after administration.…”

Distribution and outcome of ocular lesions in snakes examined at a veterinary teaching hospital: 67 cases (1985–2010)

“…Pseudomonas spp are commonly isolated from skin, ocular, and oral tissues of reptiles. 7,12,16,31 The presence of S arizonae in the subspectacular fluid of 2 snakes following surgery was not unexpected because reptiles can carry Salmonella spp, which can lead to disease, particularly if their immune system has been otherwise compromised. [31][32][33][34] Because culture was not performed until after surgery in those 2 snakes, it is unknown whether the Salmonella infection was present at initial examination or was the result of contamination of the subspectacular space from the oral cavity or skin during surgery.…”

“…7,12,16,31 The presence of S arizonae in the subspectacular fluid of 2 snakes following surgery was not unexpected because reptiles can carry Salmonella spp, which can lead to disease, particularly if their immune system has been otherwise compromised. [31][32][33][34] Because culture was not performed until after surgery in those 2 snakes, it is unknown whether the Salmonella infection was present at initial examination or was the result of contamination of the subspectacular space from the oral cavity or skin during surgery. Regardless, these findings suggested it would be prudent to perform bacteriologic culture on subspectacular fluid obtained from snakes with pseudobuphthalmos during initial examination to determine whether a concurrent infection exists and for comparison purposes should an infection of the subspectacular space subsequently develop.…”