Capture and Transfer of Simian Immunodeficiency Virus by Macaque Dendritic Cells Is Enhanced by DC-SIGN

Kimata, Monica T. Yu; Cella, Marina; Biggins, Julia E.; Rorex, Colin; White, Robert G.; Hicks, Sarah M.; Wilson, Joelle M.; Patel, Parul G.; Allan, Jonathan S.; Colonna, Marco; Kimata, Jason T.

doi:10.1128/jvi.76.23.11827-11836.2002

Cited by 29 publications

(28 citation statements)

References 48 publications

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“…This contrasts with one study which reported very low levels of DC-SIGN on rhesus macaque MDDC (61). The expression levels of DC-SIGN may vary according to the primate species and/or the donor (25,61). Numbers of DC-SIGN molecules on AGM MDDC did indeed vary according to the AGM donor, as shown for human MDDC (1).…”

Section: Discussioncontrasting

confidence: 50%

“…This has been confirmed with MDDC from six distinct AGM donors. This result supports the findings of an earlier study of Chinese macaque species, M. fascicularis, in which viral transmission is also largely DC-SIGN dependent (25). However, it contrasts with a study of M. mulatta MDDC that indicated no discernible role of DC-SIGN in viral transmission (61).…”

Section: Discussioncontrasting

confidence: 42%

“…DC-SIGN cannot replace CD4, CCR5, or CXCR4 in the process of HIV type 1 (HIV-1) entry but retains infectious particles for several days in culture (13) in a low-pH endosomal compartment (27). Similarly, DC-SIGN from macaques also acts as an attachment factor for SIVmac (2,12,25,61). In addition, coexpression of human DC-SIGN with CD4 and an appropriate coreceptor can enhance infection of HIV and SIVmac in cis (28).…”

mentioning

confidence: 99%

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DC-SIGN from African Green Monkeys Is Expressed in Lymph Nodes and Mediates Infection intransof Simian Immunodeficiency Virus SIVagm

Ploquin¹,

Diop

Sol‐Foulon³

et al. 2004

J Virol

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African green monkeys (AGMs) infected by simian immunodeficiency virus (SIV) SIVagm are resistant to AIDS. SIVagm-infected AGMs exhibit levels of viremia similar to those described during pathogenic human immunodeficiency virus type 1 (HIV-1) and SIVmac infections in humans and macaques, respectively, but contain lower viral loads in their lymph nodes. We addressed the potential role of dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN; CD209) in viral dissemination. In previous studies, it has been shown that human DC-SIGN and macaque DC-SIGN allow transmission of HIV and SIVmac to T cells. Here, we looked at the ability of DC-SIGN derived from AGM lymph nodes to interact with SIVagm. We show that DC-SIGN-expressing cells are present mainly in the medulla and often within the cortex and/or paracortex of AGM lymph nodes. We describe the isolation and characterization of at least three isoforms of dc-sign mRNA in lymph nodes of AGMs. The predicted amino acid sequence from the predominant mRNA isoform, DC-SIGNagm1, is 92 and 99% identical to the corresponding human and rhesus macaque DC-SIGN amino acid sequences, respectively. DC-SIGNagm1 is characterized by the lack of the fourth motif in the repeat domain. This deletion was also detected in the dc-sign gene derived from thirteen animals belonging to five other African monkey species and from four macaques (Macaca fascicularis and M. mulatta). Despite three-to seven-amino-acid modifications compared to DC-SIGNmac, DC-SIGNagm1 allows transmission of SIVagm to T cells. Furthermore, AGM monocyte-derived dendritic cells (MDDC) expressed at least 100,000 DC-SIGN molecules and were able to transmit SIVagm to T cells. At a low multiplicity of infection (10 ؊5 50% tissue culture infective doses/cell), viral transmission by AGM MDDC was mainly DC-SIGN dependent. The present study reveals that DC-SIGN from a natural host species of SIV has the ability to act as an efficient attachment and transmission factor for SIVagm and suggests the absence of a direct link between this ability and viral load levels in lymph nodes.

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Section: Discussioncontrasting

confidence: 50%

Section: Discussioncontrasting

confidence: 42%

mentioning

confidence: 99%

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DC-SIGN from African Green Monkeys Is Expressed in Lymph Nodes and Mediates Infection intransof Simian Immunodeficiency Virus SIVagm

Ploquin¹,

Diop

Sol‐Foulon³

et al. 2004

J Virol

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“…DCs express, among other receptors, the DC-specific ICAM3-grabbing non-integrin (DC-SIGN) receptor, a C-type lectin, which contains an external calcium-dependent mannose-binding lectin domain (1,2). DC-SIGN interacts with the envelope glycoprotein gp120 of HIV-1, HIV-2, and SIV (3)(4)(5)(6)(7)(8), as well as other pathogens such as hepatitis C (9, 10), Ebola (11), cytomegalovirus (12), Dengue virus (13), Mycobacterium (14)(15)(16), Leishmania (17,18), Candida albicans (19), and Helicobacter pylori (20,21). DC-SIGN has been implicated as playing an important role in HIV-1 transmission and the establishment of infection (4,6,(22)(23)(24)(25).…”

Section: Introductionmentioning

confidence: 99%

Lewis X component in human milk binds DC-SIGN and inhibits HIV-1 transfer to CD4+ T lymphocytes

Naarding

Ludwig²,

Groot³

et al. 2005

Journal of Clinical Investigation

170

136

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DC-specific ICAM3-grabbing non-integrin (DC-SIGN), which is expressed on DCs, can interact with a variety of pathogens such as HIV-1, hepatitis C, Ebola, cytomegalovirus, Dengue virus, Mycobacterium, Leishmania, and Candida albicans. We demonstrate that human milk can inhibit the DC-SIGN-mediated transfer of HIV-1 to CD4 + T lymphocytes as well as viral transfer by both immature and mature DCs. The inhibitory factor directly interacted with DC-SIGN and prevented the HIV-1 gp120 envelope protein from binding to the receptor. The human milk proteins lactoferrin, α-lactalbumin, lysozyme, β-casein, and secretory leukocyte protease inhibitor did not bind DC-SIGN or demonstrate inhibition of viral transfer. The inhibitory effect could be fully alleviated with an Ab recognizing the Lewis X (Le X ) sugar epitope, commonly found in human milk. Le X in polymeric form or conjugated to protein could mimic the inhibitory activity, whereas free Le X sugar epitopes could not. We reveal that a Le X motif present in human milk can bind to DC-SIGN and thereby prevent the capture and subsequent transfer of HIV-1 to CD4 + T lymphocytes. The presence of such a DC-SIGN-binding molecule in human milk may both influence antigenic presentation and interfere with pathogen transfer in breastfed infants.

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“…Second, DC-SIGN initiates interactions with naïve T cells through contact with a third ligand, ICAM-3, which is believed to stabilize DC-T cell membrane contacts and enable efficient T cell receptor engagement. Finally, DC-SIGN can internalize soluble antigen ligands, resulting in processing and presentation of antigenic peptides to T cells [23][24][25][26][27] . All of the above functions are consistent with a general model in which DCs in mucosa encounter HIV-1, internalize particles via DC-SIGN and become "Trojan horses", traveling to lymph nodes to release infectious particles into the midst of activated T cells.…”

Section: Trojan Horses: Dual Roles For Dc-signmentioning

confidence: 99%

DC-SIGN: Binding receptor for HCV?

Feng

Wang²,

Nie³

et al. 2004

WJG

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DC-SIGN, a dendritic Cell-specific adhesion receptor and a type II transmembrane mannose-binding C-type lectin, is very important in the function of DC, both in mediating naive T cell interactions through ICAM-3 and as a rolling receptor that mediates the DC-specific ICAM-2-dependent migration processes. It can be used by viral and bacterial pathogens including Human Immunodeficiency Virus (HIV), HCV, Ebola Virus, CMV and Mycobacterium tuberculosis to facilitate infection. Both DC-SIGN and DC-SIGNR can act either in cis, by concentrating virus on target cells, or in trans, by transmission of bound virus to a target cell expressing appropropriate entry receptors. Recent work showed that DC-SIGN are highaffinity binding receptors for HCV. Besides playing a role in entry into DC, HCV E2 interaction with DC-SIGN might also be detrimental for the interaction of DC with T cells during antigen presentation. The clinical strategies that target DC-SIGN may be successful in restricting HCV dissemination and pathogenesis as well as directing the migration of DCs to manipulate appropriate immune responses in autoimmunity and tumorigenic situations.

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Capture and Transfer of Simian Immunodeficiency Virus by Macaque Dendritic Cells Is Enhanced by DC-SIGN

Cited by 29 publications

References 48 publications

DC-SIGN from African Green Monkeys Is Expressed in Lymph Nodes and Mediates Infection intransof Simian Immunodeficiency Virus SIVagm

DC-SIGN from African Green Monkeys Is Expressed in Lymph Nodes and Mediates Infection intransof Simian Immunodeficiency Virus SIVagm

Lewis X component in human milk binds DC-SIGN and inhibits HIV-1 transfer to CD4+ T lymphocytes

DC-SIGN: Binding receptor for HCV?

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