Captopril Treatment of Chronic Heart Failure in the Very Old

Bock, V De; Mets, Tony; Romagnoli, Marco; Derde, M P

doi:10.1093/geronj/49.3.m148

Cited by 22 publications

(8 citation statements)

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“…Overall a significant increase of exercise performance was found in 12 of the 47 placebo controlled studies. An improvement in distance walked was reported in a percentage between 10 and 30% of the randomized studies with ACE-inhibitors, AT1 inhibitors or betablockers [50,51]. Comparison between changes of functional capacity and different end-points showed an high degree of concordance ([80%) for positive or neutral response thus suggesting that 6MWT accurately reflects clinical effects induced by treatment.…”

Section: Mwt For the Assessment Of Results Of Clinical Treatmentmentioning

confidence: 97%

Six minute walk test: a simple and useful test to evaluate functional capacity in patients with heart failure

Rostagno¹,

Gensini²

2008

Intern Emerg Med

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In heart failure survival is closely related to functional capacity. Peak O2 consumption at cardiopulmonary exercise test (CPET) is considered the gold standard for the evaluation of exercise tolerance. Since >70% of patients with heart failure, usually elderly or with significant comorbidities, are referred to Departments of Internal Medicine where facilities for cardiopulmonary test are rarely available, CPET may be performed in <5% of the patients. Six-minute walk test (6MWT) has been proposed as a simple, inexpensive, reproducible alternative to CPET. The 6MWT reproduces the activity of daily life and this is particularly relevant in elderly patients who usually develop symptoms below their theoretical maximal exercise capacity. Despite some limits 6MWT is attractive for patients referred to Departments of Internal Medicine allowing an objective evaluation of exercise tolerance, a better prognostic evaluation and a guide to evaluate response to medical treatment.

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Section: Mwt For the Assessment Of Results Of Clinical Treatmentmentioning

confidence: 97%

Six minute walk test: a simple and useful test to evaluate functional capacity in patients with heart failure

Rostagno¹,

Gensini²

2008

Intern Emerg Med

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“…The 6MWT, a well established measure of functional endurance,10, 12, 31, 35, 42 was added after a protocol amendment to determine the safety, reliability, and feasibility of the test for use as a functional endpoint after discussions regarding the design of the future treatment study pointed to the need for a functional endpoint. The 6MWT was piloted on the study cohort at the month 12 visit and was administered in accordance with American Thoracic Society (ATS) guidelines 1.…”

Section: Methodsmentioning

confidence: 99%

Clinical features of late‐onset Pompe disease: A prospective cohort study

et al. 2008

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The objective of this 12-month study was to describe the clinical features of late-onset Pompe disease and identify appropriate outcome measures for use in clinical trials. Assessments included quantitative muscle testing (QMT), functional activities (FAA), 6-min walk test (6MWT), and pulmonary function testing (PFT). Percent predicted values indicated quantifiable upper and lower extremity weakness, impaired walking ability, and respiratory muscle weakness. Significant declines in arm and leg strength and pulmonary function were observed during the study period. The outcome measures were demonstrated to be safe and reliable. Symptom duration was identified as the best predictor of the extent of skeletal and respiratory muscle weakness.

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“…41 6MWT is best used to determine the response the treatment in heart or lung disease. [42][43][44][45][46][47][48][49][50][51][52] The 6MWT has also been used as a one-time measure of functional status of patient. [53][54][55][56] …”

Section: Discussionmentioning

confidence: 99%

Co - Relation of Six Minute Walk Test With Pulmonary Function Tests in Obese Individuals Admitted for Bariatric Surgery

Bharang¹,

Dosi²,

Tonpay³

2015

jemds

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AIMS AND OBJECTIVES:To evaluate Pulmonary Function Tests and 6MWT in obese individuals and to correlate 6MWT with FEV1 and MMEF 75-25 and establish the individual significance in evaluating bariatric subjects. MATERIAL AND METHOD: Prospective observational study carried out on 50 obese patients referred to PFT Lab for pre-operative investigations (admitted for planned Bariatric Surgery) after the informed consent in Department of Respiratory Medicine, Sri Aurobindo Medical College and Post Graduate Institute, Indore (MP). Biometric data (age, sex, height and weight), Pulmonary Function Tests (PFT) and Six minute walk test (6MWT) data was collected. Exclusion criteria for study is those who were not willing, unable to perform PFT/6MWT acceptably, recent cardiac event, patients with osteoarthritis or neuromuscular disorder and patients with known pre-existing respiratory illness. STATISTICAL ANALYSIS: Statistical analysis was performed using Graphpad Quick Calcs: t test calculator software. The data were reported as mean ± standard deviation (SD). The absolute (6MWD) in meters was used. The correlation between 6MWD and the patient's pulmonary function test were evaluated by applying unpaired 't' test. 6MWT shows extremely significant correlation with FEV1and MMEF 75-25. RESULT: There is high correlation between 6MWT and PFT in obese individuals. All the patients above normal BMI have ventilatory defect which may be due to restriction imposed by abdominal wall and chemical mediators released by adipocytes. Predicted values are calculated by Udwadia Index. CONCLUSION: 6MWT is a good prognostic tool to study ventilatory mechanism in obese individuals. KEYWORDS: PFT, 6MWT, BMI, FEV1, MMEF 75/25. INTRODUCTION:Obesity is a worldwide disease of increasing prevalence, currently representing a major public health problem superimposed on ancient problems such as malnutrition and infectiouscontagious diseases in emerging countries. 1,2 The health consequences of obesity range from a higher risk of premature death to severe chronic diseases that reduce the quality of life. 1 Obesity is a chronic medical condition characterized by an excessive accumulation of fat on human body that causes a generalized increase in body mass. It is measured by using body mass index (BMI) which is a reflection of weight and height. Body mass index (BMI) is calculated as the weight in kilograms divided by the square of the height in meters (BMI = weight (kg) /height (m 2 ). The world Health Organization (WHO) classified obesity using BMI cut-off values of 25 and 30 kg/m 2 Body mass index (BMI) of 18 to 24.9 kg/m 2 is considered normal weight, a BMI of 25.0-29.9 kg/m 2 is considered overweight and a BMI of 30 kg/m 2 or higher is considered obesity. 3 To investigate the effect of obesity on the respiratory system, most researchers use values of pulmonary function tests (PFT). The factors that usually affect the values of pulmonary function tests are age, gender, height, race or ethnic origin and possibly obesity. As the individual gets ...

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Captopril Treatment of Chronic Heart Failure in the Very Old

Cited by 22 publications

References 0 publications

Six minute walk test: a simple and useful test to evaluate functional capacity in patients with heart failure

Six minute walk test: a simple and useful test to evaluate functional capacity in patients with heart failure

Clinical features of late‐onset Pompe disease: A prospective cohort study

Co - Relation of Six Minute Walk Test With Pulmonary Function Tests in Obese Individuals Admitted for Bariatric Surgery

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