Captopril is more effective than Perindopril against aluminium chloride induced amyloidogenesis and AD like pathology

Mohapatra, Debashish; Kanungo, Srikant; Pradhan, Sweta Priyadarshini; Jena, Susmita; Prusty, Shakti Ketan; Sahu, Pratap Kumar

doi:10.1016/j.heliyon.2022.e08935

Cited by 6 publications

(4 citation statements)

References 40 publications

(42 reference statements)

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“…On day 25, the AlCl 3 group took significantly longer than the control group to reach the visible platform in the Morris water maze test, demonstrating memory impairments and impaired spatial memory. Insight into the precise mechanism is provided by Mohapatra et al [ 59 ]; they found that rats exposed to AlCl 3 spent considerably more time running onto the Morris water maze platform, demonstrating an impairment in spatial memory. These symptoms have previously been linked to cognitive and memory impairments.…”

Section: Discussionmentioning

confidence: 99%

“…Relatedly, Prema et al [ 58 ] showed that rats given AlCl 3 performed better on a test of hippocampus function called the Morris water maze, indicating that the chemical had a beneficial effect on the animals’ ability to navigate the maze. Morris water maze times for AlCl 3 -treated rats were significantly longer than controls beginning on day 25, demonstrating memory and spatial memory impairment [ 59 ]. Moreover, the Morris water maze test revealed that AlCl 3 considerably increased the escape delay, indicating a loss in spatial memory.…”

Section: Discussionmentioning

confidence: 99%

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Assessment of Anti-Alzheimer Pursuit of Jambolan Fruit Extract and/or Choline against AlCl3 Toxicity in Rats

Hawash,

Yassien,

Alotaibi

et al. 2023

Toxics

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Jambolan fruit extract and choline were investigated for Aluminum tri chloride (AlCl3)-induced Alzheimer’s disease in rats. Thirty-six male “Sprague Dawley” rats weighing (150 ± 10 g) were allocated into six groups; the first group was fed a baseline diet and served as a negative control. Alzheimer’s disease (AD) was induced in Group 2 rats by oral administration of AlCl3 (17 mg/kg body weight) dissolved in distilled water (served as a positive control). Rats in Group 3 were orally supplemented concomitantly with both 500 mg/kg BW of an ethanolic extract of jambolan fruit once daily for 28 days and AlCl3 (17 mg/kg body weight). Group 4: Rivastigmine (RIVA) aqueous infusion (0.3 mg/kg BW/day) was given orally to rats as a reference drug concomitantly with oral supplementation of AlCl3 (17 mg/kg body weight) for 28 days. Group 5 rats were orally treated with choline (1.1 g/kg) concomitantly with oral supplementation of AlCl3 (17 mg/kg body weight). Group 6 was given 500 mg/kg of jambolan fruit ethanolic extract and 1.1 g/kg of choline orally to test for additive effects concurrently with oral supplementation of AlCl3 (17 mg/kg bw) for 28 days. Body weight gain, feed intake, feed efficiency ratio, and relative brain, liver, kidney, and spleen weight were calculated after the trial. Brain tissue assessment was analyzed for antioxidant/oxidant markers, biochemical analysis in blood serum, a phenolic compound in Jambolan fruits extracted by high-performance liquid chromatography (HPLC), and histopathology of the brain. The results showed that Jambolan fruit extract and choline chloride improved brain functions, histopathology, and antioxidant enzyme activity compared with the positive group. In conclusion, administering jambolan fruit extract and choline can lower the toxic impacts of aluminum chloride on the brain.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Assessment of Anti-Alzheimer Pursuit of Jambolan Fruit Extract and/or Choline against AlCl3 Toxicity in Rats

Hawash,

Yassien,

Alotaibi

et al. 2023

Toxics

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“…On the 42nd–47th days, behavioral test was performed. On the 47th day of the experiment, following a 12 h period of food deprivation, the animals were euthanized in accordance with ethical guidelines in order to obtain brain homogenates for subsequent biochemical analysis . Animals were subjected to anesthesia using an intraperitoneal injection of ketamine (75 mg/kg) and xylazine (10 mg/kg).…”

Section: Methodsmentioning

confidence: 99%

“…Aluminum (Al) is a widely recognized neurotoxic substance implicated in the pathogenesis of AD. − Al has been observed to trigger the misfolding of cytoskeleton proteins within the brain, subsequently resulting in the production of amyloid β (Aβ) plaques. , Prolonged exposure to Al has been found to induce neurodegeneration and neuronal death through apoptotic mechanisms; additionally, cognitive deficits and neuropathological alterations in the brain have been seen, leading to impaired learning abilities in rats. , Furthermore, research has also indicated that the presence of Al can lead to cognitive deficits in animal subjects. , It is widely postulated that the processes behind the induction of AD-like behaviors by aluminum mostly entail oxidative damage, the process by which tau proteins become hyperphosphorylated, accumulating the Aβ protein, increasing the activity of acetylcholinesterase (AChE), and apoptosis of neurons . Furthermore, Al has the potential to induce brain dysfunction through glial changes, in addition to its effects on neuronal activity .…”

Section: Introductionmentioning

confidence: 99%

Barbaloin’s Chemical Intervention in Aluminum Chloride Induced Cognitive Deficits and Changes in Rats through Modulation of Oxidative Stress, Cytokines, and BDNF Expression

Kazmi,

Afzal,

Imam

et al. 2024

ACS Omega

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Alzheimer's disease (AD) is a long-term neurodegenerative condition characterized by impaired cognitive functions, particularly in the domains of learning and memory. Finding promising options for AD can be successful with a medication repurposing strategy. The goal of the research was to examine the neuroprotective characteristics of barbaloin in aluminum chloride (AlCl 3 )-induced cognitive deficits and changes in rats through modulation of oxidative stress, cytokines, and brainderived neurotrophic factor (BDNF) expression. Thirty male Wistar rats were subjected to AlCl 3 at a dosage of 100 mg/kg via the per oral route (p.o.), which induced cognitive decline. Morris water maze (MWM) is used to assess behavioral metrics. Assays for catalase (CAT), malondialdehyde (MDA), reduced glutathione (GSH), acetylcholinesterase (AChE), choline-acetyltransferase (ChAT), interleukins-1β (IL-1β), superoxide dismutase (SOD), tumor necrosis factor-α (TNF-α), nuclear factor kappa-B (NF-κB), interleukins-6 (IL-6), BDNF, and neurotransmitter levels [dopamine (DA), acetylcholine (Ach), and γ-aminobutyric acid (GABA)] were performed. Results: The transfer latency time was notably decreased, and substantial modifications in the concentrations of GSH, MDA, CAT, SOD, AChE, ChAT and observed modulations in the formation of interleukins-6 (IL-6), TNF-α, IL-1β, BDNF, and NF-κB were also evidenced after the treatment of rats with barbaloin in comparison to AlCl 3 -induced control groups. Significant alterations in neurotransmitter levels (DA, Ach, and GABA) were also seen in barbaloin-treated groups in comparison to AlCl 3 -induced groups. The current investigation has provided evidence that the administration of barbaloin yielded notable enhancements in cognitive function in rats through the inhibition of MDA, enhancing endogenous antioxidant enzymes, reduction of cytokine levels, and enhancement of neurotransmitter contents in the brain. These effects were observed in comparison to a control group treated with AlCl 3 and can be attributable to barbaloin's strong anti-inflammatory and antioxidant properties, and metal chelating properties may contribute to its neuroprotective effects. Barbaloin may also promote neuronal survival and enhance learning and memory by upregulating the expression of BDNF.

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A review of the epidemiological and laboratory evidence of the role of aluminum exposure in pathogenesis of cardiovascular diseases

Tinkov,

Skalny,

Domingo

et al. 2024

Environmental Research

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Captopril is more effective than Perindopril against aluminium chloride induced amyloidogenesis and AD like pathology

Cited by 6 publications

References 40 publications

Assessment of Anti-Alzheimer Pursuit of Jambolan Fruit Extract and/or Choline against AlCl3 Toxicity in Rats

Assessment of Anti-Alzheimer Pursuit of Jambolan Fruit Extract and/or Choline against AlCl3 Toxicity in Rats

Barbaloin’s Chemical Intervention in Aluminum Chloride Induced Cognitive Deficits and Changes in Rats through Modulation of Oxidative Stress, Cytokines, and BDNF Expression

A review of the epidemiological and laboratory evidence of the role of aluminum exposure in pathogenesis of cardiovascular diseases

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