Captopril-induced pemphigus.

Parfrey, Patrick S.; Clement, Michele; Vandenburg, M. J.; Wright, P

doi:10.1136/bmj.281.6234.194

Cited by 72 publications

(21 citation statements)

References 3 publications

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“…Captopril, an oral inhibitor of angio tensin-converting enzyme, has been report ed to induce frequently various cutaneous reactions, including pemphigus [6] and lichenoid eruptions [4,5].…”

Section: Discussionmentioning

confidence: 99%

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Captopril-Induced Lichen planus pemphigoides with Pemphigus-Like Features

et al. 1986

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We report a case of a bullous lichenoid eruption due to the intake of captopril. Clinical, histological, direct immunofluorescence and ultrastructural features were consistent with the diagnosis of lichen planus pemphigoides. In addition, the in vivo immunological study also revealed an intercellular fluorescence, similar to that seen in pemphigus. Complex drug-induced cutaneous reactions have been previously reported with other drugs, especially with D-penicillamine, which bears chemical similarities with captopril. However, such a drug-induced mixed pattern of lichen planus pemphigoides with pemphigus-like features has never been reported.

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“…Captopril, an oral inhibitor of angio tensin-converting enzyme, has been report ed to induce frequently various cutaneous reactions, including pemphigus [6] and lichenoid eruptions [4,5].…”

Section: Discussionmentioning

confidence: 99%

“…Cutaneous reactions to captopril arc common, and var ious clinical patterns have been reported [2]: pruritus, urticaria, maculopapular rashes, pityriasis rosca-like eruptions [3], lichenoid eruptions [4,5] and pemphigus [6].…”

Section: Introductionmentioning

confidence: 99%

Captopril-Induced Lichen planus pemphigoides with Pemphigus-Like Features

et al. 1986

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“…It has been suggested that the cause of this early type is a pharmacologic mechanism resulting from blockade of kininase II which is thought to potentiate kinin action at the dermal level [8]. The late type appears in the form of more or less generalized rashes and especially of pemphigus [9,[10][11][12] and lichenoid eruptions [13,14]. These erup tions are not dose-dependent, require dis continuance of treatment and have an as yet unknown pathogenetic mechanism.…”

Section: Introductionmentioning

confidence: 99%

Immunohistological Study of Captopril-Induced Late Cutaneous Eruptions

Bretin¹,

Dréno²,

Bureau³

et al. 1988

Dermatology

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Immunohistological study of dermal infiltrate from two pempigus- and one captopril-induced lichenoid eruption showed the presence of a CD8 (T suppressor) infiltrate that resembled that found in skin eruptions induced by graft-versus-host disease. It is suggested that a T cell cytotoxic reaction occurs in the epidermis that might be triggered by captopril-induced modification of keratinocytic antigens

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“…Skin biopsy speci- [3] suggest that captopril-induced eruptions could be the result of potentiation of kinin-mediated cutaneous reactions. Pyritinol and penicillamine have been described as causing lichenoid eruptions similar to captopri I [9,10], and several reports [5,10] pointed out that the sulfhydryl group present in these three drugs might be the allergenic form. This group is not present in the enalapril molecule, a similar drug not related to lichenoid eruptions.…”

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confidence: 99%