Captopril does not Potentiate Post-Exercise Hypotension: A Randomized Crossover Study

Queiroz, Andréia Cristiane Carrenho; Sousa, Julio C.; Junior, Natan Daniel Silva; Tobaldini, Eleonora; Ortega, Kátia Coelho; Oliveira, Edilamar Menezes de; Brum, Patrícia Chakur; Montano, Nicola; Mion, Décio; Tinucci, Taís; Forjaz, C. L. M.

doi:10.1055/s-0042-123044

Cited by 17 publications

(27 citation statements)

References 32 publications

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“…Beaulieu et al [14] reported that a bout of aerobic exercise at 50 % of VO 2PEAK reduced SBP by 4 mmHg during 1 h post-exercise even when subjects were taking angiotensin converting enzyme inhibitor (ACEI; Fosinopril) medicine. In contrast, no effect on ambulatory blood pressure reduction were observed after a bout of resistance exercise alone or in combination with ACEI (Captopril) [15,16]. However, in line with our previous work [17,18], we find that the combination of supramaximal interval aerobic exercise and antihypertensive medication has superior effects on PEH compared to exercise alone.…”

Section: Discussionsupporting

confidence: 83%

“…To our knowledge, there are few studies in the literature investigating the effects of antihypertensive drugs on PEH (i. e., acute BP response). Nonetheless, it is difficult to draw conclusions from these studies due to differences among intensities, type of exercise (resistance vs. endurance), and kind of medication [14][15][16][17][18]. While the scientific literature is currently inconclusive, hypertensive individuals receiving ARB engage in physical activity programs, and the effects of this association need to be evaluated [19].…”

Section: Introductionmentioning

confidence: 99%

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Post-exercise Hypotension Produced by Supramaximal Interval Exercise is Potentiated by Angiotensin Receptor Blockers

et al. 2019

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We studied the effects of supramaximal interval exercise (SIE) with or without antihypertensive medication (AHM) on 21-hr blood pressure (BP) response. Twelve hypertensive patients chronically medicated with AHM, underwent three trials in a randomized order: a) control trial without exercise and substituting their AHM with a placebo (PLAC); b) placebo medicine and a morning bout of SIE (PLAC+SIE), and c) combining AHM and exercise (AHM+SIE). Acute and ambulatory blood pressure responses were measured for 21-hr after treatment. 20 min after treatment, systolic blood pressure (SBP) readings were reduced, similar to readings after PLAC+SIE (−9.7±6.0 mmHg, P<0.001) and AHM+SIE (−10.4±7.9 mmHg, P=0.001). 21 h after treatment, SBP remained reduced after PLAC+SIE (125±12 mmHg, P=0.022) and AHM+SIE (122±12 mmHg, P=0.013) compared to PLAC (132±16 mmHg). The BP reduction in PLAC+SIE faded out at 4 a.m., while in AHM+SIE it continued overnight. At night, BP reduction was larger in AHM+SIE than PLAC+SIE (–5.6±4.0 mmHg, P=0.006). Our data shows that a bout of supramaximal aerobic interval exercise in combination with ARB medication in the morning elicits a sustained blood pressure reduction lasting at least 21-h. Thus, the combination of exercise and angiotensin receptor blocker medication seems superior to exercise alone for acutely decreasing blood pressure.

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Section: Discussionsupporting

confidence: 83%

Section: Introductionmentioning

confidence: 99%

Post-exercise Hypotension Produced by Supramaximal Interval Exercise is Potentiated by Angiotensin Receptor Blockers

et al. 2019

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“…After performing aerobic exercise, PEH is most often mediated by a decrease of systemic vascular resistance, except in some special conditions in which cardiac output is reduced [2,3]. In contrast, resistance exercise generally causes PEH by a decrease in cardiac output [79,109] or a mixture of patterns across subjects [110,111]. However, studies which find decreased cardiac output can also report a decreased diastolic blood pressure [49,82,107].…”

Section: Reporting Resultsmentioning

confidence: 99%

“…For example, some studies [8,81,90,106,107,[109][110][111] observed no decrease in blood pressure after an exercise bout when relying on PEH_I analysis, but observed an increase in blood pressure from before to after a control session, showing that time alone is associated with increases in blood pressure under their specific experimental conditions. In such cases, PEH_II or PEH_III analysis can demonstrate that the exercise session had a measurable hypotensive effect, blunting the blood pressure increase that was observed with the control session [8,81,90,106,107,[109][110][111]. Based on these arguments, whether or not a particular exercise session can promote PEH can only be clearly determined if time effects are controlled by a control session.…”

Section: Different Approaches To Quantifying Pehmentioning

confidence: 99%

Recommendations in Post-exercise Hypotension: Concerns, Best Practices and Interpretation

et al. 2019

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Post-exercise hypotension (PEH) is a clinically relevant phenomenon that has been widely investigated. However, the characteristics of study designs, such as familiarization to blood pressure measurements, duration of PEH assessments or strategies to analyze PEH present discrepancies across studies. Thus identifying key points to standardize across PEH studies is necessary to help researchers to build stronger study designs, to facilitate comparisons across studies, and to avoid misinterpretations of results. The goal of this narrative review of methods used in PEH studies was therefore to gather and find possible influencers in the characteristics of study design and strategies to analyze blood pressure. Data found in this review suggest that PEH studies should have at least two familiarization screening visits, and should assess blood pressure for at least 20 min, but preferably for 120 min, during recovery from exercise. Another important aspect is the strategy to analyze PEH, which may lead to different interpretations. This information should guide a priori study design decisions.

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“…Previous studies have demonstrated controversial findings regarding how these parameters (i.e., cardiac output [CO], SV, and SVR) change after resistance exercise. Some studies found that CO decreased [ 6 , 7 , 9 , 10 ], probably due to reductions in SV [ 7 , 9 , 10 ], while one study showed unchanged CO [ 8 ]. On the other hand, it was reported that SVR increased [ 6 ], remained unchanged [ 8 , 10 ], or decreased [ 7 ] after resistance exercise.…”

Section: Discussionmentioning

confidence: 99%

Impact of Resistance Exercise under Hypoxia on Postexercise Hemodynamics in Healthy Young Males

Horiuchi

Ni-i-nou

Miyazaki

et al. 2018

International Journal of Hypertension

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We investigated the effects of resistance exercise under hypoxia on postexercise hemodynamics in eight healthy young males. The subjects belonged to a track & field club (sprinters, hurdlers, and long jumpers) and engage in regular physical training (1-2 h per day, 3-5 days per week). Each participant performed eight sets of bilateral leg squats with a one-minute interval under normoxia (room air) and hypoxia (13 % FiO2). During a 60-minute recovery, we set normoxic condition either after normoxic or hypoxic exercise. These two experimental protocols (normoxia and hypoxia) were performed in a random order with a one-week washout period. The leg squat exercise consists of 50 % 1-RM (14 repetitions) × 5 sets and 50% 1-RM (repetitions max; 7 repetitions) × 3 sets. The resting period between each set was 1 min, and a total of 91 repetitions were performed. Blood pressure, heart rate (HR), and several biomarkers were measured pre- and postexercise. The mean arterial pressure (MAP) significantly decreased after exercise compared to the pre-exercise values under both conditions (P < 0.05). The MAP at 20 and 30 min of recovery in hypoxia was significantly lower than in normoxia (P < 0.05, respectively). The antidiuretic hormone significantly increased after 60 min of recovery in both conditions; moreover, the values in hypoxia were significantly higher than those in normoxia (P < 0.05). The delta changes in MAP from baseline (pre-exercise) were significantly related to changes in HR from baseline in normoxia (r = 0.560, P < 0.001) but not in hypoxia. These results suggest that the hypoxic condition elicits greater hypotension after resistance exercise in comparison to normoxia. Moreover, the underlying mechanisms for the attenuation of hypotension after resistance exercise may differ between normoxia and hypoxia.

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Captopril does not Potentiate Post-Exercise Hypotension: A Randomized Crossover Study

Cited by 17 publications

References 32 publications

Post-exercise Hypotension Produced by Supramaximal Interval Exercise is Potentiated by Angiotensin Receptor Blockers

Post-exercise Hypotension Produced by Supramaximal Interval Exercise is Potentiated by Angiotensin Receptor Blockers

Recommendations in Post-exercise Hypotension: Concerns, Best Practices and Interpretation

Impact of Resistance Exercise under Hypoxia on Postexercise Hemodynamics in Healthy Young Males

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