Capsule shell material impacts the in vitro disintegration and dissolution behaviour of a green tea extract

Glube, Natalie; Moos, Lea von; Duchateau, Guus

doi:10.1016/j.rinphs.2013.08.002

Cited by 36 publications

(27 citation statements)

References 20 publications

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“…Glube et al [30] compared the dissolution rates of gelatin with HPMC capsules and found that more than 80% of the gelatin capsules dissolved in 20 min at pH 4.5, whereas less than 20% of the HPMC capsules dissolved in the same amount of time. In comparison, approximately 70% of the CRG-MD/SOR capsules dissolved in 20 min at pH 4.5, showing similar dissolution behavior to that of gelatin capsules.…”

Section: Disintegration and Dissolution Of Paracetamol Frommentioning

confidence: 99%

Characterization, Disintegration, and Dissolution Analyses of Carrageenan-Based Hard-Shell Capsules Cross-Linked with Maltodextrin as a Potential Alternative Drug Delivery System

Fauzi

Pudjiastuti

Hendradi

et al. 2020

International Journal of Polymer Science

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Hard-shell capsules commonly consist of gelatin which is not a universal material considering it is extracted from animal parts. Moreover, the mad cow disease triggered the scrutinization of the use of gelatin in pharmaceutical products. Hence, an alternative to conventional hard-shell capsules is needed. Carrageenan- (CRG-) based hard-shell capsules were successfully prepared by cross-linking CRG with maltodextrin (MD) and plasticizing with sorbitol (SOR). These CRG-MD/SOR hard-shell capsules were produced as an alternative to conventional hard-shell capsules in the oral drug delivery system (DDS). The physical properties of CRG-MD/SOR capsules were characterized using the degree of swelling, FTIR, and SEM analyses. The disintegration and dissolution profile release of paracetamol from CRG-MD/SOR hard-shell capsules was performed in an aqueous medium with three different pH levels. The degree of swelling of CRG-MD/SOR was 529.23±128.10%. The main peaks in the FTIR spectrum of CRG-MD/SOR were at 1248, 930, 847, and 805 cm−1 for ester sulfate groups, 3,6-anhydrogalactose, galactose-4-sulfate, and 3,6-anhydrogalactose-2-sulfate, respectively. The SEM analysis exhibited minuscule pores on the surface of CRG and CRG-MD/SOR at 5000 times of magnification. The CRG-MD/SOR capsules required 18.47±0.11 min on average to disintegrate. The CRG-MD/SOR dissolution was better in a weakly acidic medium (pH 4.5) than in a strongly acidic (pH 1.2) and neutral (pH 6.8) media. Based on the aforementioned results, CRG-MD/SOR capsules are the potential candidate to replace conventional hard-shell capsules.

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Section: Disintegration and Dissolution Of Paracetamol Frommentioning

confidence: 99%

Characterization, Disintegration, and Dissolution Analyses of Carrageenan-Based Hard-Shell Capsules Cross-Linked with Maltodextrin as a Potential Alternative Drug Delivery System

Fauzi

Pudjiastuti

Hendradi

et al. 2020

International Journal of Polymer Science

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“…It is advisable to administer HPMC capsules on an empty stomach. Addition of digestive enzymes in the dissolution medium did not alter drug release profile for either gelatin or HPMC capsules in mixed phosphate buffer (pH 6.8), in comparison to data observed in simulated medium without enzymes [36].…”

Section: Effect Of Capsule Shell-food Interaction On Release Profilementioning

confidence: 62%

“…Cations in acetate buffer did not have any negative impact on HPMC shell material. However, gelatin capsules disintegrated comparatively faster [36]. Disintegration time of spiranomycin loaded HPMC capsules in acidic medium (pH 1.2) was not altered, even after storage at 60 °C and 75% RH for 10 d. However, disintegration time was delayed with spiranomycin encapsulated in gelatin capsules [33].…”

Section: In Vitro Disintegration Testmentioning

confidence: 99%

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HPMC as Capsule Shell Material: Physicochemical, Pharmaceutical and Biopharmaceutical Properties

Majee¹,

Avlani²,

Biswas³

2017

Int J Pharm Pharm Sci

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The most common instability problem of gelatin capsules arises from negative impact of extremes of temperature and especially atmospheric relative humidity on the mechanical integrity of the capsule shells with adverse effect extended even to the fill material. Moreover, choice of fill materials is highly restricted either due to their specific chemical structure, physical state or hygroscopicity. Additional reports of unpredictable disintegration and dissolution of filled hard gelatin capsules in experimental studies have prompted the search for a better alternative capsule shell material. The present review aims to provide an overview on the physicochemical, pharmaceutical and biopharmaceutical properties of hydroxypropyl methylcellulose (HPMC) as capsule shell material and perform comparative evaluation of HPMC and gelatin in terms of in vitro/in vivo performance and storage stability. HPMC capsule provides a highly flexible and widely acceptable platform capable of solving numerous challenges currently facing the pharmaceutical and nutraceutical industries and expands the possibilities for selection of different types of fill materials. The current topic introduces a new section on influence of various factors on in vitro dissolution of HPMC capsules. Delayed in vitro disintegration/dissolution of HPMC capsules in aqueous medium does not produce any negative effect in vivo. However, advancements in the processes of production and filling of HPMC capsule shells and detailed studies on effects of various parameters on their in vitro/in vivo dissolution would establish their supremacy over hard gelatin capsules in future.

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“…This would have created a true non-protein reference and control situation. Unfortunately, HPMC material interacts with polyphenols, limiting severely the release in simulated gastrointestinal (GI) tract condition of the HPMC capsule content [29]. This effect is absent or less pronounced in the case of gelatine capsules, which are designed to disintegrate within minutes in the GI tract.…”

Section: Discussionmentioning

confidence: 99%

Impact of Proteins on the Uptake, Distribution, and Excretion of Phenolics in the Human Body

et al. 2016

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Polyphenols, a complex group of secondary plant metabolites, including flavonoids and phenolic acids, have been studied in depth for their health-related benefits. The activity of polyphenols may, however, be hampered when consumed together with protein-rich food products, due to the interaction between polyphenols and proteins. To that end we have tested the bioavailability of representatives of a range of polyphenol classes when consumed for five days in different beverage matrices. In a placebo-controlled, randomized, cross-over study, 35 healthy males received either six placebo gelatine capsules consumed with 200 mL of water, six capsules with 800 mg polyphenols derived from red wine and grape extracts, or the same dose of polyphenols incorporated into 200 mL of either pasteurized dairy drink, soy drink (both containing 3.4% proteins) or fruit-flavoured protein-free drink . At the end of the intervention urine and blood was collected and analysed for a broad range of phenolic compounds using Gas Chromatography–Mass Spectrometry (GC-MS), Liquid Chromatography–Multiple Reaction Monitoring–Mass Spectrometry (LC-MRM-MS), and Nuclear Magnetic Resonance (NMR) spectroscopy techniques. The plasma and urine concentrations of the polyphenols identified increased with all formats, including the protein-rich beverages. Compared to capsule ingestion, consumption of polyphenol-rich beverages containing either dairy, soy or no proteins had minor to no effect on the bioavailability and excretion of phenolic compounds in plasma (118% ± 9%) and urine (98% ± 2%). We conclude that intake of polyphenols incorporated in protein-rich drinks does not have a major impact on the bioavailability of a range of different polyphenols and phenolic metabolites.

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Capsule shell material impacts the in vitro disintegration and dissolution behaviour of a green tea extract

Cited by 36 publications

References 20 publications

Characterization, Disintegration, and Dissolution Analyses of Carrageenan-Based Hard-Shell Capsules Cross-Linked with Maltodextrin as a Potential Alternative Drug Delivery System

Characterization, Disintegration, and Dissolution Analyses of Carrageenan-Based Hard-Shell Capsules Cross-Linked with Maltodextrin as a Potential Alternative Drug Delivery System

HPMC as Capsule Shell Material: Physicochemical, Pharmaceutical and Biopharmaceutical Properties

Impact of Proteins on the Uptake, Distribution, and Excretion of Phenolics in the Human Body

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