Capsule Endoscopy for Gastric Evaluation

Kim, Ji-Hyun; Nam, Seung‐Joo

doi:10.3390/diagnostics11101792

Cited by 15 publications

(10 citation statements)

References 49 publications

(66 reference statements)

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“…[ 45 ] Commercial systems include the handheld MiroCam‐Navi (Intromedic Ltd., Seoul, Korea), MCE (Olympus Corp. and Siemens Healthcare), NaviCam (AnX Robotica, Wuhan, China), and the standing‐type magnetic capsule endoscopy (JIFU Medical Technologies, Shenzen, China). [ 46 ] These systems provide comprehensive digestive tract navigation, and a non‐invasive alternative to traditional endoscopic procedures, similar to the handheld magnetic actuation device demonstrated in this study. Magnetic resonance imaging (MRI) has also been proposed to guide and control magnetic manipulation devices.…”

Section: Resultsmentioning

confidence: 99%

A Magnetic Bio‐Inspired Soft Carrier as a Temperature‐Controlled Gastrointestinal Drug Delivery System

Heunis

Wang

Vente

et al. 2023

Macromolecular Bioscience

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Currently, gastrointestinal bleeding in the colon wall and the small bowel is diagnosed and treated with endoscopes. However, the locations of this condition are often problematic to treat using traditional flexible and tethered tools. New studies commonly consider untethered devices for solving this problem. However, there still exists a gap in the extant literature, and more research is needed to diagnose and deliver drugs in the lower gastrointestinal tract using soft robotic carriers. This paper discusses the development of an untethered, magnetically‐responsive bio‐inspired soft carrier. A molding process is utilized to produce prototypes from Diisopropylidene‐1,6‐diphenyl‐1,6‐hexanediol‐based Polymer with Ethylene Glycol Dimethacrylate (DiAPLEX) MP‐3510 ‐ a shape memory polymer with a low transition temperature to enable the fabrication of these carriers. The soft carrier design is validated through simulation results of deformation caused by magnetic elements embedded in the carrier in response to an external field. The thermal responsiveness of the fabricated prototype carriers is assessed ex vivo and in a phantom. The results indicate a feasible design capable of administering drugs to a target inside a phantom of a large intestine. The soft carrier introduces a method for the controlled release of drugs by utilizing the rubbery modulus of the polymer and increasing the recovery force through magnetic actuation.

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Section: Resultsmentioning

confidence: 99%

A Magnetic Bio‐Inspired Soft Carrier as a Temperature‐Controlled Gastrointestinal Drug Delivery System

Heunis

Wang

Vente

et al. 2023

Macromolecular Bioscience

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“…In addition to the infrastructure required to perform externally controlled locomotion (Figure 3), more recent reports have confirmed prolonged examination times. (Szalai et al, 2022) , (Kim and Nam, 2021) Advancements in localization VCE poses unique challenges in terms of localization. Unlike upper endoscopy and colonoscopy, which benefit from much shorter lumens and endoscopically identifiable landmarks, VCE must transit the entire small bowel, which is 18-22 feet long and without landmarks.…”

Section: Externally Controlled Locomotionmentioning

confidence: 99%

Endoscopic capsule robot-based diagnosis, navigation and localization in the gastrointestinal tract

Hanscom

Cave

2022

Front. Robot. AI

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The proliferation of video capsule endoscopy (VCE) would not have been possible without continued technological improvements in imaging and locomotion. Advancements in imaging include both software and hardware improvements but perhaps the greatest software advancement in imaging comes in the form of artificial intelligence (AI). Current research into AI in VCE includes the diagnosis of tumors, gastrointestinal bleeding, Crohn’s disease, and celiac disease. Other advancements have focused on the improvement of both camera technologies and alternative forms of imaging. Comparatively, advancements in locomotion have just started to approach clinical use and include onboard controlled locomotion, which involves miniaturizing a motor to incorporate into the video capsule, and externally controlled locomotion, which involves using an outside power source to maneuver the capsule itself. Advancements in locomotion hold promise to remove one of the major disadvantages of VCE, namely, its inability to obtain targeted diagnoses. Active capsule control could in turn unlock additional diagnostic and therapeutic potential, such as the ability to obtain targeted tissue biopsies or drug delivery. With both advancements in imaging and locomotion has come a corresponding need to be better able to process generated images and localize the capsule’s position within the gastrointestinal tract. Technological advancements in computation performance have led to improvements in image compression and transfer, as well as advancements in sensor detection and alternative methods of capsule localization. Together, these advancements have led to the expansion of VCE across a number of indications, including the evaluation of esophageal and colon pathologies including esophagitis, esophageal varices, Crohn’s disease, and polyps after incomplete colonoscopy. Current research has also suggested a role for VCE in acute gastrointestinal bleeding throughout the gastrointestinal tract, as well as in urgent settings such as the emergency department, and in resource-constrained settings, such as during the COVID-19 pandemic. VCE has solidified its role in the evaluation of small bowel bleeding and earned an important place in the practicing gastroenterologist’s armamentarium. In the next few decades, further improvements in imaging and locomotion promise to open up even more clinical roles for the video capsule as a tool for non-invasive diagnosis of lumenal gastrointestinal pathologies.

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“…As capsule endoscopes do not have the functions of water injection, suction or air inflation, the accuracy of the examination varies greatly depending on the environment in the gastrointestinal tract. In addition to adequate bowel preparation, the gastrointestinal tract should be filled with water to allow effective movement of the capsule, making exam harder for patients [41]. Magnetically controlled capsule endoscopes are being developed in the upper and lower gastrointestinal tracts and are expected to be commercialized.…”

Section: Robotics In Capsule Endoscopymentioning

confidence: 99%

Robotics in Gastrointestinal Endoscopy

et al. 2021

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Recent advances in endoscopic technology allow clinicians to not only detect digestive diseases early, but also provide appropriate treatment. The development of various therapeutic endoscopic technologies has changed the paradigm in the treatment of gastrointestinal diseases, contributing greatly to improving the quality of life of patients. The application of robotics for gastrointestinal endoscopy improves the maneuverability and therapeutic ability of gastrointestinal endoscopists, but there are still technical limitations. With the development of minimally invasive endoscopic treatment, clinicians need more sophisticated and precise endoscopic instruments. Novel robotic systems are being developed for application in various clinical fields, to ultimately develop into minimally invasive robotic surgery to lower the risk to patients. Robots for endoscopic submucosal dissection, autonomous locomotive robotic colonoscopes, and robotic capsule endoscopes are currently being developed. In this review, the most recently developed innovative endoscopic robots were evaluated according to their operating mechanisms and purpose of use. Robotic endoscopy is an innovative treatment platform for future digestive endoscopy.

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Capsule Endoscopy for Gastric Evaluation

Cited by 15 publications

References 49 publications

A Magnetic Bio‐Inspired Soft Carrier as a Temperature‐Controlled Gastrointestinal Drug Delivery System

A Magnetic Bio‐Inspired Soft Carrier as a Temperature‐Controlled Gastrointestinal Drug Delivery System

Endoscopic capsule robot-based diagnosis, navigation and localization in the gastrointestinal tract

Robotics in Gastrointestinal Endoscopy

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