Capsular inflammation after immediate breast reconstruction – Gene expression patterns and inflammatory cell infiltration in irradiated and non-irradiated breasts

Frisell, A; Bergman, Otto; Khan, Aadil; Gisterå, Anton; Lagergren, Jesper; Boniface, Jana de; Halle, Martin

doi:10.1016/j.bjps.2022.10.011

Cited by 1 publication

(2 citation statements)

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“…Conversely, some studies have shown an increase in macrophage expression after RDT, but our study found a decrease in CD68 expression in the RTD group. 7,23,24 Aside from a few discrepancies, this study found that ASC treatment is associated with reducing the severity of radiodermatitis (macroscopic and histologic analysis). Indeed, literature data have shown a benefit and safety profile when using stem cells in breast reconstruction.…”

Section: Discussionmentioning

confidence: 70%

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Effect of ASC Injection in the Inflammatory Reaction in Silicone Implant Capsule: Animal Model

Camargo,

Santos,

Cerqueira Dantas

et al. 2024

Plastic and Reconstructive Surgery - Global Open

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Background: Capsular contracture is a common complication affecting about 80% of patients who receive radiotherapy after breast reconstruction with silicone prostheses. This study examines the use of adipocyte stem cells (ASCs) to treat capsular contracture. Methods: Thirty rats were operated on to implant a minisilicone prosthesis in the dorsal region. The rats were divided into three groups: control (saline solution injection), radiotherapy (RDT), and RDT + ASC. After 3 months, the capsules were collected and submitted to histological analysis for inflammatory cell presence, vascular density, and collagen fibers, and gene expression of Tnf, Il1rap, Il10, Cd68, Mmp3, and Mmp9 by qPCR. Results: In macroscopic analysis, the RTGO score showed a two-point reduction in RDT + ASC compared with the RDT (P = 0.003). In histological analysis, ASC exhibited less than 50% of inflammatory cells compared with RDT (P = 0.004), which was similar to control. This study demonstrated that Il1rap gene expression was identical in both RDT and RTD + ASC. Compared with control, treatment with ASC reduced Il1rap expression by 30%. Cd68 and Mmp3 expression levels were similar in both the control and RTD + ASC. Conclusion: This study suggests that ASC treatment decreases silicone prosthesis capsule inflammation.

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Section: Discussionmentioning

confidence: 70%

“…Conversely, some studies have shown an increase in macrophage expression after RDT, but our study found a decrease in CD68 expression in the RTD group. 7 , 23 , 24 …”

Section: Discussionmentioning

confidence: 99%