Capsicum-infecting begomoviruses as global pathogens: host–virus interplay, pathogenesis, and management

Devendran, Ragunathan; Kumar, Manish; Ghosh, Dibyendu; Yogindran, Sneha; Karim, Mir Jishan; Chakraborty, Supriya

doi:10.1016/j.tim.2021.05.007

Cited by 33 publications

(19 citation statements)

References 73 publications

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“…Pepper plants are known to be vulnerable to various pathogens, including viruses, which cause enormous production losses. At present, pepper yellow leaf curl disease (PepYLCD) has been identified as one of the most destructive diseases that significantly affects global pepper production (Devendran et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

“…Begomovirus comprises 445 species (ICTV, 2021), all of which have genomic structures composed of one or two circular single-stranded DNAs encapsulated in twinned icosahedral particles (Brown et al, 2015). PepYLCD is prevalent in tropical and subtropical cultivation areas including Asia, America, Africa, and the Middle East (Devendran et al, 2022), where it depends on the highly polyphagous whitefly (Bemisia tabaci Genn.) for transmission to new hosts (Gillbertson et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

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Pepper (Capsicum annuum) Plants Harboring the Begomovirus Resistance Gene pepy-1 Show Delayed Symptom Progress and High Productivity Under Natural Field Conditions

et al. 2023

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Pepper yellow leaf curl disease (PepYLCD) caused by begomoviruses is one of the most devastating diseases affecting pepper (Capsicum spp.) production worldwide. In our previous study, a loss-of-function allele, pepy-1, encoding messenger RNA surveillance factor Pelota was identified as a begomovirus resistance gene from a C. annuum cultivar BaPep-5. In this study, to investigate the effectiveness of pepy-1 conferred resistance against begomovirus in the field, we conducted a three-year evaluation under natural field conditions in Indonesia. The lowest PepYLCD incidence and significantly higher fruit productivity were observed in BaPep-5 when compared to six other commonly cultivated pepper cultivars. The subsequent comparison between BaPep-5 and the susceptible BaPep-4 showed that pepy-1 slowed down the disease onset and progression, resulting in a higher fruit productivity trait in the field. Multiple comparison analyses using an F 2 population obtained by crossing BaPep-5 with BaPep-4 showed that the pepy-1 homozygous individuals had significantly higher fruit productivity, twice than those of the Pepy-1 homozygous or heterozygous individuals. In conclusion, the introgression of pepy-1 is effective to reduce the economic loss of pepper fruit production under natural field infection of begomoviruses.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Pepper (Capsicum annuum) Plants Harboring the Begomovirus Resistance Gene pepy-1 Show Delayed Symptom Progress and High Productivity Under Natural Field Conditions

et al. 2023

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“…Further, CP structure superimposition suggests an emergence of new short, small helix region (MDFG) in the NW isolate, but a loop region (PYGF) in the OW. It might be due to differences in functional requirements, such as interaction with different host factors (new vector adaptation or new host) [ 17 , 69 ]. Selected models for CP in OW and NW demonstrated accurate topology, as governed by their C score, expected TM-score, RMSD value, as well as stabilization of its stereo-chemical properties [ 70 ].…”

Section: Resultsmentioning

confidence: 99%

Comparative Genome Analysis of Old World and New World TYLCV Reveals a Biasness toward Highly Variable Amino Acids in Coat Protein

Nigam

Muthukrishnan

Flores-López

et al. 2023

Plants

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Begomoviruses, belonging to the family Geminiviridae and the genus Begomovirus, are DNA viruses that are transmitted by whitefly Bemisia tabaci (Gennadius) in a circulative persistent manner. They can easily adapt to new hosts and environments due to their wide host range and global distribution. However, the factors responsible for their adaptability and coevolutionary forces are yet to be explored. Among BGVs, TYLCV exhibits the broadest range of hosts. In this study, we have identified variable and coevolving amino acid sites in the proteins of Tomato yellow leaf curl virus (TYLCV) isolates from Old World (African, Indian, Japanese, and Oceania) and New World (Central and Southern America). We focused on mutations in the coat protein (CP), as it is highly variable and interacts with both vectors and host plants. Our observations indicate that some mutations were accumulating in Old World TYLCV isolates due to positive selection, with the S149N mutation being of particular interest. This mutation is associated with TYLCV isolates that have spread in Europe and Asia and is dominant in 78% of TYLCV isolates. On the other hand, the S149T mutation is restricted to isolates from Saudi Arabia. We further explored the implications of these amino acid changes through structural modeling. The results presented in this study suggest that certain hypervariable regions in the genome of TYLCV are conserved and may be important for adapting to different host environments. These regions could contribute to the mutational robustness of the virus, allowing it to persist in different host populations.

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“…As the most destructive pathogens, CLCuVs are widely spread in Central and South-East Asia. The viruses carry distinct recombinations to break down transgenic resistance in cotton cultivars ( Devendran et al, 2022 ).…”

Section: Navigating Clcuv Vectors: Unveiling Transmission Mechanismsmentioning

confidence: 99%

A comprehensive review on Gossypium hirsutum resistance against cotton leaf curl virus

Nadeem,

Riaz Ahmed,

Luqman

et al. 2024

Front. Genet.

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Cotton (Gossypium hirsutum L.) is a significant fiber crop. Being a major contributor to the textile industry requires continuous care and attention. Cotton is subjected to various biotic and abiotic constraints. Among these, biotic factors including cotton leaf curl virus (CLCuV) are dominant. CLCuV is a notorious disease of cotton and is acquired, carried, and transmitted by the whitefly (Bemisia tabaci). A cotton plant affected with CLCuV may show a wide range of symptoms such as yellowing of leaves, thickening of veins, upward or downward curling, formation of enations, and stunted growth. Though there are many efforts to protect the crop from CLCuV, long-term results are not yet obtained as CLCuV strains are capable of mutating and overcoming plant resistance. However, systemic-induced resistance using a gene-based approach remained effective until new virulent strains of CLCuV (like Cotton Leaf Curl Burewala Virus and others) came into existence. Disease control by biological means and the development of CLCuV-resistant cotton varieties are in progress. In this review, we first discussed in detail the evolution of cotton and CLCuV strains, the transmission mechanism of CLCuV, the genetic architecture of CLCuV vectors, and the use of pathogen and nonpathogen-based approaches to control CLCuD. Next, we delineate the uses of cutting-edge technologies like genome editing (with a special focus on CRISPR-Cas), next-generation technologies, and their application in cotton genomics and speed breeding to develop CLCuD resistant cotton germplasm in a short time. Finally, we delve into the current obstacles related to cotton genome editing and explore forthcoming pathways for enhancing precision in genome editing through the utilization of advanced genome editing technologies. These endeavors aim to enhance cotton’s resilience against CLCuD.

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Capsicum-infecting begomoviruses as global pathogens: host–virus interplay, pathogenesis, and management

Cited by 33 publications

References 73 publications

Pepper (<i>Capsicum annuum</i>) Plants Harboring the Begomovirus Resistance Gene <i>pepy-1</i> Show Delayed Symptom Progress and High Productivity Under Natural Field Conditions

Pepper (<i>Capsicum annuum</i>) Plants Harboring the Begomovirus Resistance Gene <i>pepy-1</i> Show Delayed Symptom Progress and High Productivity Under Natural Field Conditions

Comparative Genome Analysis of Old World and New World TYLCV Reveals a Biasness toward Highly Variable Amino Acids in Coat Protein

A comprehensive review on Gossypium hirsutum resistance against cotton leaf curl virus

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