“…However, their acceptance in large-scale production is undivulged, as the dependency of performance on factors such as substrate concentration, reaction media characteristics, water influence, thermal stability, and lipase immobilization must be comprehensively understood before their integration. , The limitations mentioned above can be circumvented by utilizing heterogeneous catalysis in conjunction with reactive separation technology, wherein the reaction and separation co-occur. This technology brings the best of both worlds by abrogating the associated environmental hazards of the conventional catalysts while overcoming many reaction limitations like the formation of side products such as alkenes, ethers, and oligomers, − sensitivity of molecules to high temperature, and slow reaction rates, thus increasing conversion in equilibrium-limited reactions. ,, …”