Capsiate-Rich Fraction of Capsicum annuum Induces Muscular Glucose Uptake, Ameliorates Rosiglitazone-Induced Adipogenesis, and Exhibits Activation of NRs Regulating Multiple Signaling Pathways
Hee-Sung Chae,
Charles L. Cantrell,
Ikhlas A. Khan
et al.
Abstract:Capsiate is a key ingredient in the
fruits of a nonpungent
cultivar
of Capsicum annuum. We investigated
the effects of a C. annuum extract
(CE) and a capsiate-rich fraction of CE (CR) on nuclear receptors
involved in multiple signaling pathways, glucose uptake, and adipogenesis
in comparison to pure capsiate (Ca). Similar to the effect of Ca (100
μM), CE (500 μg/mL) and CR (100 μg/mL) caused the
activation of PPARα and PPARγ (>3-fold), while CR also
activated LXR and NRF2 (>2 fold). CR (200 μg/mL) and Ca (100
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