Capsaicin Treatment Attenuates Cholangiocarcinoma Carcinogenesis

Wutka, Annika; Palagani, Vindhya; Barat, Samarpita; Chen, Xi; Khatib, Mona El; Götze, Julian; Belahmer, Hanane; Zender, Steffen; Bożko, Przemysław; Malek, Nisar P.; Plentz, Ruben R.

doi:10.1371/journal.pone.0095605

Cited by 35 publications

(22 citation statements)

References 57 publications

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“…These effects were correlated with the down-regulation of phosphatidylinositol 3-kinase (PI3-K) and Akt [18]. Several other malignancies that have reported anti-migratory effects include cholangiocarcinoma and urothelial carcinoma [19,20]. Although the effects of PI3-K and Akt have not been investigated in our study, it is possible that modulation of this pathway could play a role in the anti-metastatic effects that we have found.…”

Section: Discussionmentioning

confidence: 52%

Capsaicin reduces the metastatic burden in the transgenic adenocarcinoma of the mouse prostate model

et al. 2015

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Section: Discussionmentioning

confidence: 52%

Capsaicin reduces the metastatic burden in the transgenic adenocarcinoma of the mouse prostate model

et al. 2015

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“…Hedgehog signaling components are overexpressed in iCCA [107][108][109], and it has been shown that GLI1 and GLI2 overexpression was associated with intrahepatic metastasis and poorer OS and DFS [108]. A role of Hedgehog signaling in EMT has been described in human CCA cells and CCA xenografted tumors by modulating E-cadherin expression [107] Consistently, inhibition of Hedgehog signaling by cyclopamine [107] or capsaicin [110] up-regulated E-cadherin expression [107] and impaired EMT in CCA [110]. Figure 2E) miRs are deeply involved in EMT regulation [14].…”

Section: Hedgehog Signaling Upon Hedgehog Ligand Binding Gpcr-like mentioning

confidence: 89%

Epithelial-mesenchymal transition in cholangiocarcinoma: From clinical evidence to regulatory networks

Vaquero

Guedj

Clapéron

et al. 2017

Journal of Hepatology

124

122

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Cholangiocarcinoma (CCA) is an aggressive tumor with a poor prognosis due to its late clinical presentation and the lack of effective non-surgical therapies. Unfortunately, most of the patients are not eligible for curative surgery owing to the presence of metastases at the time of diagnosis. Therefore, it is important to understand the steps leading to cell dissemination in patients with CCA. To metastasize from the primary site, cancer cells must acquire migratory and invasive properties by a cell plasticity-promoting phenomenon known as epithelial-mesenchymal transition (EMT). EMT is a reversible dynamic process by which epithelial cells gradually adopt structural and functional characteristics of mesenchymal cells, and has lately become a center of attention in the field of metastatic dissemination. In the present review, we aim to provide an extensive overview of the current clinical data and the prognostic value of different EMT markers that have been analyzed in CCA. We summarize all the regulatory networks implicated in EMT from the membrane receptors to the main EMT-inducing transcription factors (SNAIL, TWIST and ZEB). Furthermore, since a tumor is a complex structure not exclusively formed by tumor cells, we also address the prominent role of the main cell types of the desmoplastic stroma that characterizes CCA in the regulation of EMT. Finally, we discuss the therapeutic considerations and difficulties faced to develop an effective anti-EMT treatment due to the redundancies and bypasses among the pathways regulating EMT. 4Key Point Box -EMT is an early event of metastasis that endows tumor cells with invasive properties enabling them to spread toward other territories.-EMT contributes to CCA progression and chemoresistance.-The three families of transcription factors that regulate epithelial and mesenchymal marker expression during EMT (SNAIL, TWIST and ZEB) contribute to CCA progression.-Cells of CCA microenvironment, and not only cancer cells, lead to the activation of EMT.

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“…In another study, proliferation, migration and invasion of human cholangiocarcinoma cells were all effectively inhibited by capsaicin, which was associated with regulating the Hedgehog signaling pathway [208]. …”

Section: Red Chili Pepper and Capsaicinmentioning

confidence: 99%

Spices for Prevention and Treatment of Cancers

et al. 2016

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Spices have been widely used as food flavorings and folk medicines for thousands of years. Numerous studies have documented the antioxidant, anti-inflammatory and immunomodulatory effects of spices, which might be related to prevention and treatment of several cancers, including lung, liver, breast, stomach, colorectum, cervix, and prostate cancers. Several spices are potential sources for prevention and treatment of cancers, such as Curcuma longa (tumeric), Nigella sativa (black cumin), Zingiber officinale (ginger), Allium sativum (garlic), Crocus sativus (saffron), Piper nigrum (black pepper) and Capsicum annum (chili pepper), which contained several important bioactive compounds, such as curcumin, thymoquinone, piperine and capsaicin. The main mechanisms of action include inducing apoptosis, inhibiting proliferation, migration and invasion of tumors, and sensitizing tumors to radiotherapy and chemotherapy. This review summarized recent studies on some spices for prevention and treatment of cancers, and special attention was paid to bioactive components and mechanisms of action.

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Capsaicin Treatment Attenuates Cholangiocarcinoma Carcinogenesis

Cited by 35 publications

References 57 publications

Capsaicin reduces the metastatic burden in the transgenic adenocarcinoma of the mouse prostate model

Capsaicin reduces the metastatic burden in the transgenic adenocarcinoma of the mouse prostate model

Epithelial-mesenchymal transition in cholangiocarcinoma: From clinical evidence to regulatory networks

Spices for Prevention and Treatment of Cancers

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