Capsaicin production by Alternaria alternata, an endophytic fungus from Capsicum annum; LC–ESI–MS/MS analysis

Devari, Shekaraiah; Jaglan, Sundeep; Kumar, Manjeet; Deshidi, Ramesh; Guru, Santosh Kumar; Bhushan, Shashi; Kushwaha, Manoj; Gupta, Ajai Prakash; Gandhi, Sumit G.; Sharma, Jai P.; Taneja, Subhash C.; Vishwakarma, Ram A.; Shah, Bhahwal Ali

doi:10.1016/j.phytochem.2013.12.001

Cited by 85 publications

(33 citation statements)

References 27 publications

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“…Catharanthus roseus is well known for the production of several anticancer vinca alkaloids such as vincristine, vindesine, vinorelbine, vinblastin and the recently discovered vinfl unine (Kumar et al, 2014). The two major anticancer vinca alkaloids, vincristine and vinblastine, used in chemotherapy regimens, have been isolated from leaves (Kumar et al, 2014).…”

Section: Catharanthus Roseus (L) Gdon (Apocynaceae)mentioning

confidence: 99%

“…The two major anticancer vinca alkaloids, vincristine and vinblastine, used in chemotherapy regimens, have been isolated from leaves (Kumar et al, 2014).…”

Section: Catharanthus Roseus (L) Gdon (Apocynaceae)mentioning

confidence: 99%

“…An endophytic fungal strain identifi ed as Alternaria alternata has been isolated from fruits of C. annuum and has been found to produce and secrete capsaicin up to three generations (Devari et al, 2014).…”

Section: Capsicum Annuum L (Solanaceae)mentioning

confidence: 99%

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Endophytic fungi residing in medicinal plants have the ability to produce the same or similar pharmacologically active secondary metabolites as their hosts

Venieraki

Dimou

Katinakis

2017

Hellenic Plant Protection Journal

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SummaryMedicinal plants have been used for thousands of years in folk medicines and still are used for their health benefi ts. In our days medicinal plants are exploited for the isolation of plant-derived drugs as they are very eff ective and have relatively less or no side eff ects. However, the natural resources of medicinal plants are gradually exhausted and access to plant bioactive compounds is challenged by the low levels at which these products accumulate in native medicinal plants. For instance, to meet the market demands of 3 Kg per year of vinca alkaloids, powerful plant-derived anticancer drugs, 1.5x106 Kg dry leaves are required. In this regard, this review aims to highlight the fact that endophytic fungi residing in medicinal plants are capable to biosynthesize pharmacologically active secondary metabolites similar or identical to those produced by their host medicinal plant. Furthermore, the evolutionary origin of the genes involved in these metabolic pathways as well as the approaches designed to enhance the production of these metabolites by the isolated endophytic fungi are also discussed.Additional key words: metabolites from endophytic bacteria and actinomycetes, chemical ecology present in virtually all organs of a given plant host, and some are seed borne. Endophytes often confer considerable benefi ts to the host plant they inhabit, since they can promote the growth of host plants, enhance resistance to biotic and abiotic stresses (Rodriguez et al., 2009; Hardoim et al., 2015), and accumulate bioactive secondary metabolites (Kusari et al., 2012). The ecological role of secondary metabolites produced by endophytes is not clear. However, recent studies have shown that these metabolites are involved in deterrence of herbivory (Pannaccione et al., 2014), protection against fungal (Soliman et al., 2015) or bacterial pathogens (Mousa et al., 2017) and amelioration of plant abiotic stress (Hamayum et al., 2016). Bioactive secondary metabolites derived from medicinal plants are gradually decreasing -Alternative approaches for their productionMedicinal plants, as a rich source of nat-

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Section: Catharanthus Roseus (L) Gdon (Apocynaceae)mentioning

confidence: 99%

“…The two major anticancer vinca alkaloids, vincristine and vinblastine, used in chemotherapy regimens, have been isolated from leaves (Kumar et al, 2014).…”

Section: Catharanthus Roseus (L) Gdon (Apocynaceae)mentioning

confidence: 99%

See 1 more Smart Citation

Endophytic fungi residing in medicinal plants have the ability to produce the same or similar pharmacologically active secondary metabolites as their hosts

Venieraki

Dimou

Katinakis

2017

Hellenic Plant Protection Journal

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“…During our investigation of endophytic fungi from important medicinal plants (Devari et al . ; Guru et al . ; Arora et al .…”

Section: Introductionmentioning

confidence: 98%

New cytochalasin fromRosellinia sanctae-cruciana, an endophytic fungus ofAlbizia lebbeck

et al. 2018

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“…), capsaicin by Alternaria alternata from Capsicum annuum (Devari et al . ), the steroidal alkaloids speimisine and peiminine by Fusarium sp . from Fritillaria unibracteata (Pan et al .…”

Section: Introductionmentioning

confidence: 99%

Solamargine production by a fungal endophyte of Solanum nigrum

et al. 2016

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Capsaicin production by Alternaria alternata, an endophytic fungus from Capsicum annum; LC–ESI–MS/MS analysis

Cited by 85 publications

References 27 publications

Endophytic fungi residing in medicinal plants have the ability to produce the same or similar pharmacologically active secondary metabolites as their hosts

Endophytic fungi residing in medicinal plants have the ability to produce the same or similar pharmacologically active secondary metabolites as their hosts

New cytochalasin fromRosellinia sanctae-cruciana, an endophytic fungus ofAlbizia lebbeck

Solamargine production by a fungal endophyte of Solanum nigrum

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