Capsaicin potentiates 1,25-dihydoxyvitamin D3- and all-trans retinoic acid-induced differentiation of human promyelocytic leukemia HL-60 cells

Kang, S N; Chung, Sung Min; Kim, Tae S.

doi:10.1016/s0014-2999(01)00994-3

Cited by 34 publications

(19 citation statements)

References 36 publications

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“…Recently, capsaicin has been receiving attention as an anticancer agent because of its pharmacologic and toxicologic properties (6)(7)(8)(9)(10). This study shows that capsaicin inhibits the growth of prostate cancer cells including androgen-independent PC-3 tumors growing in mice without causing gross toxicity of the animals.…”

Section: Discussionmentioning

confidence: 82%

“…Topically, capsaicin has therapeutic value in a variety of neuropathic pain conditions including rheumatoid arthritis, cluster headaches, herpes zoster, and vasomotor rhinitis (2)(3)(4)(5). Furthermore, capsaicin decreases the growth of human leukemic cells (6)(7)(8), gastric (9), and hepatic carcinoma cells in vitro (10). However, the mechanism of capsaicin-induced growth inhibition remains unclear, and the effect of capsaicin on the growth of human prostate cancer cells has not been studied.…”

Section: Introductionmentioning

confidence: 99%

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Capsaicin, a Component of Red Peppers, Inhibits the Growth of Androgen-Independent, p53 Mutant Prostate Cancer Cells

et al. 2006

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Capsaicin is the major pungent ingredient in red peppers. Here, we report that it has a profound antiproliferative effect on prostate cancer cells, inducing the apoptosis of both androgen receptor (AR)-positive (LNCaP) and -negative (PC-3, DU-145) prostate cancer cell lines associated with an increase of p53, p21, and Bax. Capsaicin down-regulated the expression of not only prostate-specific antigen (PSA) but also AR. Promoter assays showed that capsaicin inhibited the ability of dihydrotestosterone to activate the PSA promoter/enhancer even in the presence of exogenous AR in LNCaP cells, suggesting that capsaicin inhibited the transcription of PSA not only via downregulation of expression of AR, but also by a direct inhibitory effect on PSA transcription. Capsaicin inhibited NF-K activation by preventing its nuclear migration. In further studies, capsaicin inhibited tumor necrosis factor-A-stimulated degradation of IKBA in PC-3 cells, which was associated with the inhibition of proteasome activity. Taken together, capsaicin inhibits proteasome activity which suppressed the degradation of IKBA, preventing the activation of NF-KB. Capsaicin, when given orally, significantly slowed the growth of PC-3 prostate cancer xenografts as measured by size [75 F 35 versus 336 F 123 mm 3 (FSD); P = 0.017] and weight [203 F 41 versus 373 F 52 mg (FSD); P = 0.0006; capsaicin-treated versus vehicletreated mice, respectively]. In summary, our data suggests that capsaicin, or a related analogue, may have a role in the management of prostate cancer. (Cancer Res 2006; 66(6): 3222-9)

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Section: Discussionmentioning

confidence: 82%

Section: Introductionmentioning

confidence: 99%

Capsaicin, a Component of Red Peppers, Inhibits the Growth of Androgen-Independent, p53 Mutant Prostate Cancer Cells

et al. 2006

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“…ATRA combinations with histone deacetylase inhibitors, 19) gefitinib, 20) and carnosic acid 21) have exerted synergistic effects on HL-60 leukemia cell differentiation. In the same way, capsaicin, 22) ascorbate, 23) and cyclooxygenase inhibitors 24) have enhanced the HL-60 cell differentiation produced by a low level of 1,25-(OH) 2 D 3 . Such analogues of vitamin D 3 as 1,25-(OH) 2 D 3 are used clinically for the treatment of psoriasis.…”

Section: Discussionmentioning

confidence: 85%

Enhancement of 1,25-Dihydroxyvitamin D₃- and All-transRetinoic Acid-Induced HL-60 Leukemia Cell Differentiation byPanax ginseng

Kim

Cho

Simkhada

et al. 2009

Bioscience, Biotechnology, and Biochemistry

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“…This multiplicity is necessary to assess multiple inputs and multiple endpoints in parallel. Third, this cell line shows evidence of nonlinear, non-obvious interactions, essential to prove TransForm's ability to explore the combinatorial space (33)(34)(35)(36)(37)(38)(39)(40).…”

Section: Resultsmentioning

confidence: 97%

Combination of automated high throughput platforms, flow cytometry, and hierarchical clustering to detect cell state

et al. 2007

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Background: This study examined whether hierarchical clustering could be used to detect cell states induced by treatment combinations that were generated through automation and high-throughput (HT) technology. Data-mining techniques were used to analyze the large experimental data sets to determine whether nonlinear, non-obvious responses could be extracted from the data. Methods: Unary, binary, and ternary combinations of pharmacological factors (examples of stimuli) were used to induce differentiation of HL-60 cells using a HT automated approach. Cell profiles were analyzed by incorporating hierarchical clustering methods on data collected by flow cytometry. Data-mining techniques were used to explore the combinatorial space for nonlinear, unexpected events. Additional small-scale, follow-up experiments were performed on cellular profiles of interest. Results: Multiple, distinct cellular profiles were detected using hierarchical clustering of expressed cell-surface antigens. Data-mining of this large, complex data set

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Capsaicin potentiates 1,25-dihydoxyvitamin D3- and all-trans retinoic acid-induced differentiation of human promyelocytic leukemia HL-60 cells

Cited by 34 publications

References 36 publications

Capsaicin, a Component of Red Peppers, Inhibits the Growth of Androgen-Independent, p53 Mutant Prostate Cancer Cells

Capsaicin, a Component of Red Peppers, Inhibits the Growth of Androgen-Independent, p53 Mutant Prostate Cancer Cells

Enhancement of 1,25-Dihydroxyvitamin D₃- and All-transRetinoic Acid-Induced HL-60 Leukemia Cell Differentiation byPanax ginseng

Combination of automated high throughput platforms, flow cytometry, and hierarchical clustering to detect cell state

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Capsaicin potentiates 1,25-dihydoxyvitamin D3- and all-trans retinoic acid-induced differentiation of human promyelocytic leukemia HL-60 cells

Cited by 34 publications

References 36 publications

Capsaicin, a Component of Red Peppers, Inhibits the Growth of Androgen-Independent, p53 Mutant Prostate Cancer Cells

Capsaicin, a Component of Red Peppers, Inhibits the Growth of Androgen-Independent, p53 Mutant Prostate Cancer Cells

Enhancement of 1,25-Dihydroxyvitamin D3- and All-transRetinoic Acid-Induced HL-60 Leukemia Cell Differentiation byPanax ginseng

Combination of automated high throughput platforms, flow cytometry, and hierarchical clustering to detect cell state

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Product

Resources

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Enhancement of 1,25-Dihydroxyvitamin D₃- and All-transRetinoic Acid-Induced HL-60 Leukemia Cell Differentiation byPanax ginseng