2023
DOI: 10.1016/j.bcp.2023.115530
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Capsaicin inhibits aortic valvular interstitial cell calcification via the redox-sensitive NFκB/AKT/ERK1/2 pathway

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Cited by 9 publications
(4 citation statements)
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“…53,54 CAP can also inhibit the calcification of aortic valve interstitial cells through the NF-κB/ AKT/ERK1/2 pathway, which is sensitive to oxidative stress and inflammation. 55 Markers of the AKT, ERK1/2, and NF-κB signaling pathways, including phosphorylated AKT, ERK1/2, NF-κB, and IκBα, was upregulated in calcified cells, and they are significantly downregulated after CAP treatment. Moreover, a 2023 study indicated that the traditional Chinese medicine salidroside can protect against PM2.5-induced lung injury by inhibiting cell pyroptosis and apoptosis through the NF-κB pathway.…”
Section: Discussionmentioning
confidence: 94%
“…53,54 CAP can also inhibit the calcification of aortic valve interstitial cells through the NF-κB/ AKT/ERK1/2 pathway, which is sensitive to oxidative stress and inflammation. 55 Markers of the AKT, ERK1/2, and NF-κB signaling pathways, including phosphorylated AKT, ERK1/2, NF-κB, and IκBα, was upregulated in calcified cells, and they are significantly downregulated after CAP treatment. Moreover, a 2023 study indicated that the traditional Chinese medicine salidroside can protect against PM2.5-induced lung injury by inhibiting cell pyroptosis and apoptosis through the NF-κB pathway.…”
Section: Discussionmentioning
confidence: 94%
“…Lucigenin chemiluminescence assay is widely used to detect the levels of superoxide anion radical production by biological systems ( Li et al ., 1998 ). In consistent with other studies the level of NADPH oxidase was upregulated in calcified cells ( Liberman et al ., 2008 ; Okamoto et al ., 2014 ; Liu et al ., 2020 ; Adhikari et al ., 2023 ). This increase in NADPH oxidase was downregulated with niclosamide treatment dose dependently.…”
Section: Resultsmentioning
confidence: 99%
“…China is one of the earliest countries to use chili peppers as medicine, and traditional Chinese medicine uses chili peppers to treat stomach cold, rheumatism, and other diseases. Researches showed that capsaicin, an important component of chili pepper, has anti-inflammatory, analgesic, anesthetic and detoxification effects ( Zhang et al, 2022 ; Adhikari et al, 2023 ; Li et al, 2023 ). Its analgesic effect is equal to that of morphine, but more lasting than that of morphine.…”
Section: Introductionmentioning
confidence: 99%