Capsaicin-induced transcriptional changes in hypothalamus and alterations in gut microbial count in high fat diet fed mice

Baboota, Ritesh K.; Murtaza, Nida; Jagtap, Sneha; Singh, D. P.; Karmase, Aniket; Kaur, Jaspreet; Bhutani, K. K.; Boparai, Ravneet K.; Premkumar, Louis S.; Kondepudi, Kanthi Kiran; Bishnoi, Mahendra

doi:10.1016/j.jnutbio.2014.04.004

Cited by 88 publications

(68 citation statements)

References 56 publications

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“…In addition, capsaicin had been reported to alter gut microbial composition [19]. Figure 3A-3B confirmed that capsaicin could affect the gut microbiota as evidenced by decreased Firmicutes, increased Bacteroidetes and impaired Firmicutes/Bacteroidetes ratio in the cecum of HFD and capsaicin co-treated mice compared with HFD mice.…”

Section: Resultssupporting

confidence: 53%

Dietary capsaicin and antibiotics act synergistically to reduce non-alcoholic fatty liver disease induced by high fat diet in mice

Luo

Jiang

et al. 2017

Oncotarget

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The prevalence of non-alcoholic fatty liver disease is increasing rapidly worldwide. However, effective strategies for combating high-fat diet (HFD) induced obesity, fatty liver and metabolic disorder are still limited, and outcomes remain poor. In the present study, we evaluated the combined actions of dietary capsaicin and antibiotics on HFD-induced physiological abnormalities in mice. C57BL/6 male mice were fed with HFD (60% calories from fat) for 17 weeks, and the resultant pathophysiological effects were examined. Antibiotic treatment markedly attenuated gut inflammation and leakiness induced by HFD, whereas capsaicin showed limited effects on the gut. However, dietary capsaicin significantly increased PPAR-α expression in adipose tissue, while antibiotics had no such effect. Animals treated with a combination of capsaicin and antibiotics had the smallest body weight gain and fat pad index, as well as the lowest hepatic fat accumulation. Combination treatment also maximally improved insulin responsiveness, as indicated by insulin tolerance tests. These results suggest the co-treatment of capsaicin and antibiotics, a novel combination strategy, would play synergistically to attenuate the HFD-induced obesity, fatty liver and metabolic disorder.

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Section: Resultssupporting

confidence: 53%

Dietary capsaicin and antibiotics act synergistically to reduce non-alcoholic fatty liver disease induced by high fat diet in mice

Luo

Jiang

et al. 2017

Oncotarget

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show abstract

“…These studies suggested that TRPV1 and/or CGRP might manifest dual roles in metabolic regulation [26]. Moreover, the oral intake of capsaicin also changed the gut microbial environment in high-fat-diet-fed mice [27]. In the current trial, gut and intestinal flora may also have been altered in the women with GDM.…”

Section: Discussionmentioning

confidence: 54%

Capsaicin-containing chili improved postprandial hyperglycemia, hyperinsulinemia, and fasting lipid disorders in women with gestational diabetes mellitus and lowered the incidence of large-for-gestational-age newborns

et al. 2016

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“…These findings indicate that capsaicin sensitive cells around the fourth ventricle are involved in the suppression of sham feeding by some of the intestinal nutrients (57). TRPV1 expression in the hypothalamus was down-regulated in high-fat diet treated mice, while dietary capsaicin increased TRPV1 expression levels (58). Capsaicin treatment in high-fat diet mice enhanced the expression of anorexic genes (e.g., urocortin, peptide YY) in the hypothalamus compared to the high-fat diet alone, whereas the expression of orexigenic genes was decreased (58).…”

Section: The Influence Of Trpv1 and Trpa1 On Autonomic Circuitsmentioning

confidence: 99%

“…TRPV1 expression in the hypothalamus was down-regulated in high-fat diet treated mice, while dietary capsaicin increased TRPV1 expression levels (58). Capsaicin treatment in high-fat diet mice enhanced the expression of anorexic genes (e.g., urocortin, peptide YY) in the hypothalamus compared to the high-fat diet alone, whereas the expression of orexigenic genes was decreased (58). Here, we give and overview of the cellular effects of TRPV1 and TRPA1 activation on neuronal activity in autonomic areas of the brain.…”

Section: The Influence Of Trpv1 and Trpa1 On Autonomic Circuitsmentioning

confidence: 99%

“…Mice kept on high-fat and capsaicin diet for three months showed alteration in anorectic, orexigenic and energy expenditure related genes in white adipose tissue (WAT) compared to high-fat diet and standard diet controls (58). Capsaicin supplementation resulted in “browning” genotype in WAT and increased genes related to thermogenesis and mitochondrial function in brown adipose tissue (BAT) (58). Ingestion of the TRPA1 agonist cinnamaldehyde has been shown to reduce visceral adipose tissue in mice fed a high-fat high-sucrose diet (82).…”

Section: Trpv1 and Trpa1 In Adipose Tissuementioning

confidence: 99%

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Potential therapeutic value of TRPV1 and TRPA1 in diabetes mellitus and obesity

Derbenev

Zsombok

2015

Semin Immunopathol

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Diabetes mellitus and obesity, which is a major risk factor in the development of type 2 diabetes mellitus, have reached epidemic proportions worldwide including the United States. The current statistics and forecasts, both short- and long-term, are alarming and predict severe problems in the near future. Therefore, there is a race for developing new compounds, discovering new receptors or finding alternative solutions to prevent and/or treat the symptoms and complications related to obesity and diabetes mellitus. It is well demonstrated that members of the transient receptor potential (TRP) superfamily play a crucial role in a variety of biological functions both in health and disease. In the recent years, transient receptor potential vanilloid type 1 (TRPV1) and transient receptor potential ankyrin 1 (TRPA1) were shown to have beneficial effects on whole body metabolism including glucose homeostasis. TRPV1 and TRPA1 have been associated with control of weight, pancreatic function, hormone secretion, thermogenesis and neuronal function; which suggest a potential therapeutic value of these channels. This review summarizes recent findings regarding TRPV1 and TRPA1 in association with whole body metabolism with emphasis on obese and diabetic conditions.

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Capsaicin-induced transcriptional changes in hypothalamus and alterations in gut microbial count in high fat diet fed mice

Cited by 88 publications

References 56 publications

Dietary capsaicin and antibiotics act synergistically to reduce non-alcoholic fatty liver disease induced by high fat diet in mice

Dietary capsaicin and antibiotics act synergistically to reduce non-alcoholic fatty liver disease induced by high fat diet in mice

Capsaicin-containing chili improved postprandial hyperglycemia, hyperinsulinemia, and fasting lipid disorders in women with gestational diabetes mellitus and lowered the incidence of large-for-gestational-age newborns

Potential therapeutic value of TRPV1 and TRPA1 in diabetes mellitus and obesity

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