Capsaicin in Albino Rats Prevents Contralateral Testis from the Damaging Effects Posed by Ipsilateral Testis That Underwent Torsion

Sarioğlu, A; Gedikoğlu, Gökhan; Bingöl-Koloğlu, Meltem; Büyükpamukçu, Nebìl; Tanyel, Feridun Cahit

doi:10.1159/000049818

Cited by 10 publications

(4 citation statements)

References 28 publications

(38 reference statements)

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“…Previous reports show that capsaicin, a powerful neurotoxin selective to afferent nerves, effectively prevents contralateral testicular damage in ipsilateral testicular torsion [15]. The results of the present study suggest that capsaicin can also prevent the apoptotic changes in the contralateral testis during ipsilateral testicular torsion.…”

Section: Discussionsupporting

confidence: 73%

“…Hypoxia is among the factors that induce apoptosis [14]. Contralateral testicular damage can be prevented by administering capsaicin, probably through the maintenance of blood flow, by inhibiting the afferent impulses from the ipsilateral testis under stress [15]. Therefore we devised a study to evaluate the effect of afferent nerve destruction (by capsaicin) on apoptosis within the contralateral testis associated with ipsilateral testicular torsion.…”

Section: Introductionmentioning

confidence: 99%

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Capsaicin effectively prevents apoptosis in the contralateral testis after ipsilateral testicular torsion

Sarioglu-Buke

Erdem²,

Gedikoğlu³

et al. 2001

BJU International

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Objective To evaluate the effect of afferent nerve blockage by administration of capsaicin on apoptotic changes in the contralateral testis in rats undergoing ipsilateral testicular torsion. Materials and methods Twenty male albino rats were randomly divided into four groups. In groups 1 and 2, rats underwent a sham operation and testicular torsion, respectively, after the intraperitoneal administration of 0.9% NaCl. Similarly, in groups 3 and 4 the rats underwent a sham operation and testicular torsion, respectively, after an intraperitoneal capsaicin injection. The testes were untwisted 24 h later and the contralateral testes harvested. Apoptosis was assessed in paraf®n-embedded sections stained for nuclear DNA fragmentation. Fifteen cells were counted in each seminiferous tubule and the apoptotic cells recorded. A score was calculated for each group and the results compared using the Kruskal-Wallis analysis of variance and Mann Whitney U-tests, with P<0.05 considered to be signi®cant. Results The mean apoptotic score of group 2 was signi®cantly higher than that of the other groups. There was no difference between the apoptotic scores of groups 1 and 3, 1 and 4, and 3 and 4. Conclusion Capsaicin effectively prevented apoptosis in the contralateral testes of rats that had undergone testicular torsion.

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Section: Discussionsupporting

confidence: 73%

Section: Introductionmentioning

confidence: 99%

Capsaicin effectively prevents apoptosis in the contralateral testis after ipsilateral testicular torsion

Sarioglu-Buke

Erdem²,

Gedikoğlu³

et al. 2001

BJU International

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“…The doses of CAP used in our cultures were based on previous reports in other cell types [ 22 , 23 ] and our experience with the spermatogonial stem cell lines. The effect of CAP on testes has previously been demonstrated by others, [ 24 , 25 ] but spermatogonia are located outside of the Sertoli cell blood barrier [ 26 ]. therefore we conducted our study with a direct exposure of spermatogonia to CAP.…”

Section: Discussionmentioning

confidence: 98%

Spermatogonial stem cell sensitivity to capsaicin: An in vitro study

Mizrak

Gadella

Erdost

et al. 2008

Reprod Biol Endocrinol

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Background: Conflicting reports have been published on the sensitivity of spermatogenesis to capsaicin (CAP), the pungent ingredient of hot chili peppers. Here, the effect of CAP on germ cell survival was investigated by using two testis germ cell lines as a model. As CAP is a potent agonist of the transient receptor potential vanilloid receptor 1 (TRPV1) and no information was available of its expression in germ cells, we also studied the presence of TRPV1 in the cultured cells and in germ cells in situ.

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“…Oxidative stress has been proposed to occur through afferent impulses from ipsilateral testis or vas deferens under distress via an increase in the sympathetic outflow [13,14]. Since chemical sympathectomy or afferent nerve destruction prevents, contralateral testicular damage has been suggested to reflect tissue hypoxia due to a decrease in blood flow via an increase in sympathetic tonus [15,16]. The association of two distressing conditions that affect the ipsilateral testis, such as abdominal placement and vas deferens ligation, has been shown to further augment the damage found in both testes [7].…”

Section: Discussionmentioning

confidence: 99%

Orchidopexy or Orchidectomy for Preventing Tissue Hypoxia in Contralateral Testis following Induction of Ipsilateral Abdominal Testis Associated with Vas deferens Obstruction

Otcu¹,

Karnak²,

Kilinç

et al. 2003

Urol Int

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Introduction: An experimental study was planned to evaluate and compare the effects of orchidopexy and orchidectomy on ipsilateral and contralateral testes in rats subjected to ipsilateral abdominal testis and vas deferens obstruction. Materials and Methods: Four groups of 12 rats each were established. Sham operation, intra-abdominal testis with vas deferens obstruction and orchidopexy or orchidectomy for prior intra-abdominal testis with vas deferens obstruction were performed in groups 1, 2, 3 and 4, respectively. While testes were maintained for 8 weeks in the same position in groups 1 and 2, orchidopexy or orchidectomy was performed in groups 3 and 4 after the first 4 weeks, and the remaining testes were harvested after an additional 4 weeks. Lactic acid hypoxanthine contents were determined and the groups were compared with the paired t test. Results: Maintaining intra-abdominal testis with vas deferens obstruction for 8 weeks and orchidopexy yielded the highest lactate values. However lactate levels in contralateral testes did not increase. On the other hand, hypoxanthine levels revealed the highest values after the initial 4 weeks. The 8-week study period resulted in increases of ipsilateral and contralateral testicular hypoxanthine levels. Orchidopexy caused a decrease in ipsilateral testicular values and ameliorated the increase in hypoxanthine levels in contralateral testes. Conclusions: Replacing an intra-abdominal testis with its vas deferens ligated into the scrotum ameliorates the oxidative stress in both ipsilateral and contralateral testes. Since orchidectomy does not result in better contralateral testicular values, orchidopexy should be preferred when treating an undescended testis with vasal obstruction.

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Capsaicin in Albino Rats Prevents Contralateral Testis from the Damaging Effects Posed by Ipsilateral Testis That Underwent Torsion

Cited by 10 publications

References 28 publications

Capsaicin effectively prevents apoptosis in the contralateral testis after ipsilateral testicular torsion

Capsaicin effectively prevents apoptosis in the contralateral testis after ipsilateral testicular torsion

Spermatogonial stem cell sensitivity to capsaicin: An in vitro study

Orchidopexy or Orchidectomy for Preventing Tissue Hypoxia in Contralateral Testis following Induction of Ipsilateral Abdominal Testis Associated with Vas deferens Obstruction

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