Capsaicin improves sperm quality in rats with experimental varicocele

Hosseini, Mahshid; Tavalaee, Marziyeh; Rahmani, Mohsen; Eskandari, Anahita; Shaygannia, Erfaneh; Kiani-Esfahani, Abbas; Zohrabi, Dina; Nasr-Esfahani, Mohammad Hossein

doi:10.1111/and.13762

Cited by 7 publications

(2 citation statements)

References 42 publications

(44 reference statements)

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“…These results were an important indicator that varicocele negatively affected the histological structure of seminiferous tubules. In previous studies, it has been reported that varicocele negatively affected spermatogenesis and caused a decrease in the Johnsen score (Hosseini et al., 2020; Tek et al., 2009; Zhang et al., 2018; Zheng et al., 2008) also lead to a decrease in MSTD and MSET in seminiferous tubules (Chen et al., 2009; Choi et al., 1990; Hosseini et al., 2020; Zhang et al., 2018). The data obtained in the V group in the present study are in line with the above literatures.…”

Section: Discussionmentioning

confidence: 97%

Thymoquinone improves testicular damage and sperm quality in experimentally varicocele‐induced adolescent rats

et al. 2021

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The aim of this study was to investigate the protective and therapeutic effects of thymoquinone against the negative effects of varicocele on testicular tissue and sperm morphology. Five groups were formed by random selection from a total of 40 adult male Wistar rats (n = 8). Thymoquinone (5 mg/kg/day) was administered intraperitoneally to the varicocele‐dimethyl sulfoxide‐olive oil‐thymoquinone (VT) group and the sham‐thymoquinone group. At the end of the 60th day, all groups were anaesthetised and the left testis was removed from the body quickly. One half of the testis tissue, which was divided into two, was separated for biochemical and Western blot analysis, while the other half were fixed in Bouin's fixative. As a result of biochemical, molecular and histopathological analyses, a statistically significant increase was found in the varicocele group testicular tissues in the malondialdehyde level, apoptotic index, Bax expression, cytochrome c expression and Bax/Bcl‐2 ratio compared with the sham group. In addition, histopathological changes characterised by partial or complete degeneration of the germinal epithelium were observed in the seminiferous tubules in the same group. Total oxidant status level and sperm count with abnormal morphology increased in varicocele group, whereas total antioxidant status level decreased. In the VT group, all of the biochemical, molecular and histopathological changes detected in the varicocele group were statistically significantly reduced. When the findings obtained in this study are evaluated, it can be said that thymoquinone has the potential to be used as a preventive and therapeutic pharmacological agent in the medical treatment of varicocele. Although the exact mechanism of action of thymoquinone has not been fully elucidated, the findings obtained in this study support the view that thymoquinone showed a cytoprotective effect by reducing apoptosis, oxidative stress and lipid peroxidation.

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Section: Discussionmentioning

confidence: 97%

Thymoquinone improves testicular damage and sperm quality in experimentally varicocele‐induced adolescent rats

et al. 2021

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“…Mitochondrial oxidative phosphorylation is essential for the production of large levels of viable energy within sperm cells, which is required for normal motility. Coenzyme Q10, also known as CoQ10, is an antioxidant that assists in the elimination of potentially dangerous free radicals that are produced in the mitochondria as a result of the electron transport chain [271]. In spite of this, low levels of CoQ10 have been seen in males who are unable to father children [272].…”

Section: Coenzyme Q10mentioning

confidence: 99%

Role of Antioxidants of Natural Herbs in Management of Male Infertility

Gaznee¹,

Kohli²,

Kumar³

2023

J. Res. Appl. Sci. Biotechnol.

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If you and your spouse have been trying to conceive for a year and neither of you has been successful, there is a possibility that you are one of the 50–80 million people throughout the world who struggle with infertility. There is a male component present in approximately 20%-30% of these instances. It is common knowledge that low-quality sperm and oxidative stress (OS) both have a role in the aetiology of male infertility. Because of the oxidation of DNA, proteins, and lipids, excessive levels of reactive oxygen species (ROS) have the potential to disrupt the viability, motility, and morphology of sperm cells. ROS are responsible for these changes. Methods: Through the use of the PubMed interface, we searched the MEDLINE database for studies that had been completed and published during the past ten years that analysed the effect that antioxidants had on sperm in infertile guys (2012–2022). A number of different phrases, including infertility, alpha-lipoic acid, zinc, folate, coenzyme Q10, selenium, and vitamin, were utilised during the search. The study's findings indicate that inositol serves a purpose in a number of different mechanisms that foster contacts between sperm and oocytes, and that it also affects OS levels in sperm cells by way of its engagement in mitochondrial events. Alpha-lipoic acid (ALA) lessens the damage caused by reactive oxygen species (ROS) and improves the quality of sperm in a number of ways, including motility, morphology, and count. There might be a connection between not getting enough zinc in your diet and having low-quality sperm. Zinc and folate are two nutrients that can boost the quantity and quality of sperm. When taken orally, coenzyme Q10 increases the number of sperm as well as their overall motility and forward movement. A therapy with selenium (Se) results in an improvement in the sperm's overall quality, and this improvement is connected with an increase in ejaculatory production. Only vitamin B12 has been found to improve the quality of sperm; it does this by boosting sperm count and motility and by decreasing sperm DNA damage. Vitamin B12 is the only vitamin that has been proved to do this. Conclusions: Dietary supplementation with antioxidants may improve sperm quality in men with low-quality semen by reducing OS-induced sperm damage and increasing hormone synthesis and spermatozoa concentration, motility, and morphology. This may be achieved in men who also have low levels of antioxidants in their semen. Antioxidants can exert their effects in a variety of ways; hence, it is important for researchers conducting future clinical trials to study the possibility of combining a number of antioxidants.

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TRPV1 in male reproductive system: focus on sperm function

Xiao

Chen

2022

Mol Cell Biochem

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Capsaicin improves sperm quality in rats with experimental varicocele

Cited by 7 publications

References 42 publications

Thymoquinone improves testicular damage and sperm quality in experimentally varicocele‐induced adolescent rats

Thymoquinone improves testicular damage and sperm quality in experimentally varicocele‐induced adolescent rats

Role of Antioxidants of Natural Herbs in Management of Male Infertility

TRPV1 in male reproductive system: focus on sperm function

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