Capsaicin for non-allergic rhinitis

Gevorgyan, Artur; Segboer, Christine; Gorissen, Rob; Drunen, Cornelis M. van; Fokkens, Wytske J.

doi:10.1002/14651858.cd010591.pub2

Cited by 29 publications

(28 citation statements)

References 28 publications

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“…Moreover, a decrease in nasal chemical sensitivity could be demonstrated by means of nasal mucosal potential measurements after capsaicin treatment in parallel with a decrease in (NHR) symptoms . A recent Cochrane review states that given the fact that many other options do not work well in IR patients, capsaicin is a reasonable option to try under physician supervision. Capsaicin nasal treatment has not been shown to be effective in AR, where the IgE‐mediated pathway is predominant and so far no overexpression of TRPV1 could be demonstrated .…”

Section: Treatment Of Nasal Hyperreactivitymentioning

confidence: 99%

“…Capsaicin nasal treatment has not been shown to be effective in AR, where the IgE‐mediated pathway is predominant and so far no overexpression of TRPV1 could be demonstrated . In spite of these convincing data, capsaicin is not widely used to treat NHR . The main reasons are probably the facts that treatment with capsaicin is time‐consuming (5 hours in hospital setting) and financially not interesting for ENT physicians and the pharmaceutical industry.…”

Section: Treatment Of Nasal Hyperreactivitymentioning

confidence: 99%

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Nasal hyperreactivity in rhinitis: A diagnostic and therapeutic challenge

Gerven

Steelant

Hellings

2018

Allergy

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Although nasal hyperreactivity (NHR) is a common feature in patients suffering from allergic and nonallergic rhinitis, it is widely neglected during history taking, underdiagnosed in the majority of patients with rhinitis and rhinosinusitis, not considered as an outcome parameter in clinical trials on novel treatments for rhinitis and rhinosinusitis, and no target for routine treatment. In contrast to the simple nature of diagnosing NHR by a history of nasal symptoms induced by nonspecific exogenous and/or endogenous triggers, quantification is hardly performed in routine clinic given the lack of a simple tool for its diagnosis. of NAR. In this recent publication, 5 the pathophysiology of IR was studied rather than the prevalence and the inclusion criteria for IR were stricter than for NAR which explains the lower patient

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Section: Treatment Of Nasal Hyperreactivitymentioning

confidence: 99%

Section: Treatment Of Nasal Hyperreactivitymentioning

confidence: 99%

Nasal hyperreactivity in rhinitis: A diagnostic and therapeutic challenge

Gerven

Steelant

Hellings

2018

Allergy

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“…At present, multiple studies have reported on the efficacy of capsaicin nasal treatment in idiopathic rhinitis (IR), with moderate to total symptom relief in up to 70‐80% of patients . We reported on the molecular mechanisms underlying the efficacy of capsaicin nasal treatment, providing the first evidence for a reduction of nasal hyper‐reactivity (NHR) and reduced expression of the nociceptive cation channel TRPV1 in IR by capsaicin .…”

Section: Patient Characteristicsmentioning

confidence: 99%

Therapeutic effect of capsaicin nasal treatment in patients with mixed rhinitis unresponsive to intranasal steroids

Gerven

Steelant

Alpízar

et al. 2017

Allergy

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Literature is convincing regarding the efficacy of capsaicin nasal treatment in idiopathic rhinitis (IR). However, up to 50% of IR patients do not meet the strict inclusion criteria of the trials conducted so far. As a consequence, the efficacy of capsaicin is unknown in a significant number of IR patients that do not meet the strict inclusion/exclusion criteria (J Allergy Clin Immunol. 2014;133:1332, J Allergy Clin Immunol. 2017; [Epub ahead of print]). "Mixed rhinitis" (MR) patients have more than one major etiologic factor involved in the mucosal pathology. We have no idea about the efficacy of capsaicin nasal spray in these patients nor about the time interval to seek a second application. We report here that capsaicin nasal spray is effective in a broader group of IR than the purely selected ones described before, that subjective nasal hyper-reactivity is a good predictor of positive outcome, and that the time interval for seeking a second treatment is likely to be shorter in MR patients than in the strictly selected IR patients.

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“…Fokkens W et al, (2016) mentioned the activity of capsicum against rhinitis but it is not effective for elderly patient on rhinitis 115 . Other scientist are also determined activeness of capsicum against rhinitis [116][117] .…”

Section: Rhinitismentioning

confidence: 99%

Untitled

2017

IJPSR

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Nature always stands as a golden mark to exemplify the outstanding phenomena of symbiosis. Natural products from plant, animal and minerals have been the basis of the treatment of human disease. Capsicum plants belongs to the family Solanaceae and kingdom Plantae, consist of 27 species, and approximately 3000 varieties. Chili peppers are used worldwide in foods for their pungent flavor, aroma, and to prolong food spoilage. With capsaicin contents ranging from zero to millions of Scoville heat units, the different varieties offer a wide range of options for people all over the world. The aim of present review is to form a short compilation of the pharmacological and toxicological potentials of this multipurpose fruit. Capsicum, has been used as anti-inflammatory, anti-diabetic, anti-cancer, anti-ulcer, anticoagulant, analgesic, anti-arthritis, immuno-modulatory, memory enhancing, pain relief, hypocholesterolaemic, hypolipidemic, hepatoprotective and antimicrobial effects. It also cause irritation to mucous membrane, inflammation and neurotoxicity. It should not be used on open wounds or abrasions, or near the eyes. It has antagonistic effects on of α-adrenergic blockers, clonidine and methyldopa.

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Capsaicin for non-allergic rhinitis

Cited by 29 publications

References 28 publications

Nasal hyperreactivity in rhinitis: A diagnostic and therapeutic challenge

Nasal hyperreactivity in rhinitis: A diagnostic and therapeutic challenge

Therapeutic effect of capsaicin nasal treatment in patients with mixed rhinitis unresponsive to intranasal steroids

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