Capsaicin derived from endemic chili landraces combats Shigella pathogen: Insights on intracellular inhibition mechanism

Das, Subhasish; Priyadarshani, Nayana; Basak, Priyanka; Maitra, Priyanka; Bhattacharya, Sushmita; Bhattacharya, Satya Sundar

doi:10.1016/j.micpath.2023.106210

Microbial Pathogenesis

2023

DOI: 10.1016/j.micpath.2023.106210

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Capsaicin derived from endemic chili landraces combats Shigella pathogen: Insights on intracellular inhibition mechanism

Subhasish Das,

Nayana Priyadarshani,

Priyanka Basak

et al.

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2024

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Cited by 2 publications

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Preparation, pungency, and bioactivity of capsaicin: a review

Zhang,

Huang,

Soladoye

et al. 2024

Int J of Food Sci Tech

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SummaryCapsaicin is the main pungent compound in red pepper responsible for its dual attributes of culinary utility and bioactive efficacy. This review aims to systematically review the preparation methods, pungency, and bioactivities of capsaicin. Capsaicin can be extracted by maceration, microwave, near‐infrared extraction, supercritical fluid, and ultrasound‐assisted extraction methods. Also, it can be synthesised through chemical, biosynthetic, and in vitro cell methods. Capsaicin can elicit a pungent sensation via activation of TRPV1 receptor. Furthermore, it has been reported to display various bioactivities, such as hypoglycaemic, hypolipidemic, analgesic, anti‐cancer, anti‐inflammatory, and intestinal health‐protecting activities via several signalling pathways. Overall, this review can provide a theoretical reference for understanding the preparation, pungent sensation, and bioactivities of capsaicin.

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Preparation, pungency, and bioactivity of capsaicin: a review

Zhang,

Huang,

Soladoye

et al. 2024

Int J of Food Sci Tech

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Use of Chitosan as a Precursor for Multiple Applications in Medicinal Chemistry: Recent Significant Contributions

Quiroga,

Coy-Barrera

2024

MRMC

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Abstract:: Chitosan (CS) is a polymer made up of mainly deacetylated β-1,4 D-glucosamine units, which is part of a large group of D-glucosamine oligomers known as chitooligosaccharides, which can be obtained from chitin, most abundant natural polymer after cellulose and central component of the shrimp exoskeleton. It is known that it can be used for the development of materials, among which its use stands out in wastewater treatment (removal of metal ions, dyes, and as a membrane in purification processes), food industry (anti-cholesterol and fat, packaging material, preservative, and food additive), agriculture (seed and fertilizer coating, controlled release agrochemicals), pulp and paper industry (surface treatment, adhesive paper), cosmetics (body creams, lotions, etc.), in the engineering of tissues, wound healing, as excipients for drug administration, gels, membranes, nanofibers, beads, microparticles, nanoparticles, scaffolds, sponges, and diverse biological ones, specifically antibacterial and antifungal activities. This article reviews the main contributions published in the last ten years regarding the use and application of CS in medical chemistry. The applications exposed here involve regenerative medicine in the design of bioprocesses and tissue engineering, Pharmaceutical sciences to obtain biomaterials, polymers, biomedicine, and the use of nanomaterials and nanotechnology, toxicology, and Clinical Pharmaceuticals, emphasizing the perspectives and the direction that can take research in this area.

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Capsaicin derived from endemic chili landraces combats Shigella pathogen: Insights on intracellular inhibition mechanism

Cited by 2 publications

References 49 publications

Preparation, pungency, and bioactivity of capsaicin: a review

Preparation, pungency, and bioactivity of capsaicin: a review

Use of Chitosan as a Precursor for Multiple Applications in Medicinal Chemistry: Recent Significant Contributions

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