Capsaicin and capsiate could be appropriate agents for treatment of obesity: A meta-analysis of human studies

Zsiborás, Csaba; Mátics, Róbert; Hegyi, Péter; Balaskó, Márta; Pétervári, Erika; Szabó, Imre; Patrícia, Silvia; Mikó, Alexandra; Tenk, Judit; Rostás, Ildikó; Pécsi, Dániel; Garami, András; Rumbus, Zoltán; Huszár, Orsolya; Solymár, Margit

doi:10.1080/10408398.2016.1262324

Cited by 69 publications

(58 citation statements)

References 54 publications

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“…Conflicting results have been found on the properties of capsaicin and capsiate in decreasing the respiratory quotient by enhancing fat oxidation, due to the different designs of the studies, the body composition and BMI of the subjects included and the habitual consumption of chili in their diet [152][153][154]. Interestingly, the consumption of 2.56 mg of capsaicin (1.03 g of dried red chili pepper) per meal was able to mitigate the unfavorable negative energy balance effect of decrease in DIT and REE induced by a 25% caloric restriction in humans [155].…”

Section: Chili Pepper (Capsicum Species) Available Evidencementioning

confidence: 99%

“…In mice, dietary capsaicin activated thermogenesis in WAT by up-regulating the expression of SIRT1 and PGC-1α, both of which increase the expression of UCP1 and bone morphogenetic protein-8b, resulting in energy dissipation by thermogenesis, increased EE and metabolic activity [156]. Both in mice and humans, capsaicin and capsinoids enhance energy expenditure by triggering BAT through multiple mechanisms, such as the stimulation of non-shivering thermogenesis by binding to TRPV1, stimulation of the SNS and catecholamine secretion from the adrenal gland [19,137,[152][153][154]156,157].…”

Section: Molecular Mechanisms Of Actionmentioning

confidence: 99%

“…Side effects with higher doses of capsaicin, even when provided in capsule form (up to 135 mg/day) include low palatability, gastric distress, dyspepsia, anal burning, bowel irregularities and diarrhea [153]. Capsiate is more tolerable due to its non-pungent characteristics deriving from rapid hydrolysis in the oral cavity, with reduced accessibility to nociceptors [153,154].…”

Section: Toxicity and Reactivitymentioning

confidence: 99%

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A Critical Review on the Role of Food and Nutrition in the Energy Balance

Fadda

Fedele

et al. 2020

Nutrients

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The mass media has increasingly frequently suggested to the general population that specific foods or nutritional schemes are able to affect both human metabolism and energy expenditure, thus facilitating weight loss. This critical review is aimed at assessing available evidence on the roles of nutrients, food and dietary regimens in energy intake and energy expenditure. We queried the National Library of Medicine, the Cochrane Library, Excerpta Medica dataBASEand the Cumulative Index to Nursing and Allied Health Literature database, and a search strategy was performed by using database-specific subject headings and keywords. We found that available scientific evidence on these topics is scarce, and that the limited number of available studies often have poor methodological quality. Only a few foods show beneficial effects on metabolism and energy expenditure, as the human energy balance is complex and multifactorial. Finally, microbiota may interfere with the intake, use and expenditure of energy in the human body. Conclusive evidence is still lacking, and, at present, it is not possible to identify a food or a diet with a significant impact on human energy expenditure.

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Section: Chili Pepper (Capsicum Species) Available Evidencementioning

confidence: 99%

Section: Molecular Mechanisms Of Actionmentioning

confidence: 99%

Section: Toxicity and Reactivitymentioning

confidence: 99%

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A Critical Review on the Role of Food and Nutrition in the Energy Balance

Fadda

Fedele

et al. 2020

Nutrients

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“…Also, several preclinical and clinical studies have indicated that either capsiate alone or in combination with CAP is beneficial to counteract obesity and increase energy utilization [60][61][62][63][64]. However, the mechanisms behind such effect of CAP or capsiate still remain elusive.…”

Section: Trpv1: Capsaicin Receptormentioning

confidence: 99%

CAP and Metabolic Diseases: A Mini Review on Preclinical Mechanisms and Clinical Efficacy

Thyagarajan¹,

Krishnan²,

Baskaran³

2018

Capsaicin and Its Human Therapeutic Development

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Capsaicin (CAP) is the chief active ingredient of natural chili peppers. It has culinary and medicinal benefits. CAP activates its receptor, transient receptor potential vanilloid subfamily 1 (TRPV1), which is expressed in the sensory and motor neurons, adipocytes, liver, vascular smooth muscle cells, neuromuscular junction, skeletal muscle, heart and brain. The specificity of CAP to activate TRPV1 is the fundamental mechanism for its medicinal benefits to treat pain, obesity, hypertension, and other diseases. Preclinical data from rodent model of high fat diet-induced obesity collectively suggest that CAP exerts its effects by activating TRPV1 signaling pathway, which stimulates thermogenic mechanisms in the white and brown adipose tissues to induce browning of white adipose tissues and brown adipose tissue thermogenesis. This leads to enhancement of metabolic activity and thermogenesis to counter obesity. Although CAP and its pungent and nonpungent analogs are used in human clinical studies, their effects on satiety and energy expenditure have been the highlights of such studies. The precise mechanism of action of CAP has not been evaluated in humans. This article summarizes these data and suggests that long-term safety and tolerance studies are important for advancing CAP to treat human obesity.

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“…Because overweight and obesity are the result of a sustained imbalance between caloric intake and caloric expenditure, lifestyle changes including calorie restriction and increasing energy expenditure are the two cornerstones in their treatment. Additionally, there are commercial formulations in the market that claimed as capable of enhancing the effects of lifestyle changes with a variable degree of scientific evidence 4,5 .…”

Section: Introductionmentioning

confidence: 99%