Caprylate-Dependent Auto-Anti-e

Abstract

A caprylate-dependent autoantibody with specificity for the e antigen of red cells is described. The antibody was completely inactivated by 2-mercaptoethanol and was probably of the IgM immunoglobulin class. The antibody had no apparent specificity for albumin. Reactivity of the described antibody may depend upon conformational change of red cell Rh antigen by caprylate.

11‐Oxycorticosteroid‐Dependent Antibody in the Serum of a Patient with Bladder Neoplasm

“…One of the least frequent causes of positive pretransfusion tests is the presence in the patient's serum of antibodies against chloramphenicol [5], neomycin [6], tetracycline [3], hydrocortisone [7], which are often used as preservatives in the preparation of reagent RBCs. It may also be produced by alloantibodies or autoantibodies whose detection requires the presence of drugs, such as caprylate (autoanti-e) [8], borate (anti-A) [9] ,chloramphenicol (anti-A,) [lo], paraben (autoanti-Jka) [ll], thimerosal (IgG autoantibody) [12], sodium azide (anti-I) [13], LISS (anti-Pr,) [14]. Drug-dependent antibodies without apparent group specificity have also been described [15], and some antidrug antibodies may adhere to the RBC surface by means of the Matuhasi-Ogata phenomenon…”

In vitro reactions with red blood cells that are not due to blood group antibodies: a review

“…They also showed that the patient's serum would react with RBCs in the presence of sodium caprylate without any bovine albumin being present. 48 Two examples of fatty acid-dependent antibodies were reported as having blood group specificity, an antic 49 and an anti-e. 50 Hossaini et al 51 were able to induce caprylate-dependent antibodies in rabbits.…”