Capnocytophaga canimorsus sepsis in a methotrexate-treated patient with rheumatoid arthritis

Tamura, Shinobu; Koyama, Asumi; Yamashita, Yusuke; Shiotani, Chieko; Nakamoto, Hiromichi; Nakamoto, Chiaki; Suzuki, Mizuto; Nakano, Yoshio; Imaoka, Koichi; Sawada, Takashi; Fujimoto, Tokuzo

doi:10.1016/j.idcr.2017.08.002

Cited by 6 publications

(3 citation statements)

References 20 publications

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“…This individual subsequently died of disseminated intravascular coagulation, and acute respiratory distress syndrome from C canimorsus infection following dog bite. 16 Our patient notably had poor dentition with dense plaques, multiple dental caries, and a habit of re-chewing saved tobacco, stored at room temperature, which may have contributed to increased oral bacterial colonization. The mechanism of his bacteremia in this patient was thought to be translocation of oral flora colonized with C gingivalis through compromised gastric mucosa due to the upper GI bleeding.…”

Section: Discussionmentioning

confidence: 84%

Capnocytophaga gingivalis Bacteremia After Upper Gastrointestinal Bleeding in Immunocompromised Patient

Lawal

Baer

2021

Journal of Investigative Medicine High Impact Case Reports

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Odontogenic bacteremia, most commonly involving gram-positive oral flora, can result from daily self-care practices or professional dental procedures. Though usually transient and quickly cleared by the immune system, the presence of periodontal disease increases the frequency of exposure and risk of persistence of oral-systemic infections. Comorbidities such as asplenia, alcoholism, and immunocompromise increase the risk of complications of hematogenous spread and severe systemic illness. Capnocytophaga is a genus of anaerobic fastidious gram-negative bacilli, which is a common member of human oral flora, and its density is proportional to mass of dental plaques and periodontal diseases. Capnocytophaga spp that colonize humans are less virulent and are uncommon causes of bacteremia when compared with the Capnocytophaga typical of canines. C gingivalis has been rarely reported as a cause of disease in immunocompromised or immunocompetent hosts. In this article, we present a case of an immunocompromised 70-year-old man with poor oral hygiene, on methotrexate and prednisone for rheumatoid arthritis and sarcoidosis, who was admitted for chronic obstructive pulmonary disease exacerbation and developed C gingivalis bacteremia and septic shock after an episode of upper gastrointestinal bleeding. Poor oral hygiene in our patient is believed to have increased his risk as an immunocompromised patient to developing C gingivalis bacteremia. This case highlights the importance of oral care in immunocompromised patients especially while hospitalized, and those about to receive transplant, chemotherapy, or on immune modulators.

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Section: Discussionmentioning

confidence: 84%

Capnocytophaga gingivalis Bacteremia After Upper Gastrointestinal Bleeding in Immunocompromised Patient

Lawal

Baer

2021

Journal of Investigative Medicine High Impact Case Reports

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“…Among a variety of reasons for immunocompromise, the absence of spleen remains the most common associated risk factor for systemic infections with Capnocytophaga spp. after a dog bite [1] , [10] , [11] , [12] , [13] , [14] .…”

Section: Discussionmentioning

confidence: 99%

A classic case of Capnocytophaga induced septic shock with multi-organ failure after a dog bite in an asplenic patient

Duncan

Ahuja

Khan

et al. 2023

IDCases

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“…In the period 1990–2022, 125 articles described 207 cases of C. canimorsus infection (Supplemental Table). 12 …”

Section: Review Of the Literaturementioning

confidence: 99%

The Great pretender: the first case of septic shock due to Capnocytophaga canimorsus in Sardinia. A Case report and review of the literature

Sardo

Pes

Corona

et al. 2022

Journal of Public Health Research

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Capnocytophaga canimorsus (C. canimorsus) is an emerging pathogen in critical care. C. canimorsus is a Gram-negative bacillus, commonly isolated as a commensal microorganism of the oral flora of healthy dogs and cats. A 63-year-old woman came to the emergency department with fever, chills, and malaise 2 days after a minor dog bite. After admission to the medicine ward, she developed respiratory failure and livedo reticularis. In the intensive care unit (ICU), she presented full-blown septic shock with thrombocytopenia, coagulopathy, severe acute kidney injury, and liver injury. We describe the first case of septic shock with Multiple Organ Dysfunction Syndrome related to Capnocytophaga canimorsus infection in Sardinia and its treatment in a tertiary hospital ICU. We also review recent literature on the relevance of C. canimorsus in human disease and critical illness.

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Capnocytophaga canimorsus sepsis in a methotrexate-treated patient with rheumatoid arthritis

Cited by 6 publications

References 20 publications

Capnocytophaga gingivalis Bacteremia After Upper Gastrointestinal Bleeding in Immunocompromised Patient

Capnocytophaga gingivalis Bacteremia After Upper Gastrointestinal Bleeding in Immunocompromised Patient

A classic case of Capnocytophaga induced septic shock with multi-organ failure after a dog bite in an asplenic patient

The Great pretender: the first case of septic shock due to Capnocytophaga canimorsus in Sardinia. A Case report and review of the literature

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