Capillary zone electrophoresis: its applicability and potential in biochemical analysis

Deyl, Z.; Struzinsky, R.

doi:10.1016/0378-4347(91)80227-4

Cited by 90 publications

(10 citation statements)

References 134 publications

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“…The evolution of automated instru ments has helped to spur the devel opment of a vast array of applica tions and separation media (6,7). Separation modes such as free solu tion electrophoresis, isoelectric fo cusing (IEF), micellar electrokinetic capillary chromatography (MECC), and sieving-based separations cou pled with rapid, automated method development have led to widespread acceptance.…”

mentioning

confidence: 99%

Sensitivity Enhancement for Capillary Electrophoresis

Albin¹,

Grossman²,

Moring³

1993

Anal. Chem.

137

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Capillary electrophoresis (CE) continues to grow rapidly as an analytical technique in a wide range of application areas (1-5), Typically, CE separations are performed in fusedsilica capillaries with internal diameters of 25-100 pm. High heat dissipation efficiencies in the narrow columns allow separations to be performed at high field strengths (200-500 V/cm), resulting in short analysis times and peak efficiencies of up to millions of theoretical plates.

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mentioning

confidence: 99%

Sensitivity Enhancement for Capillary Electrophoresis

Albin¹,

Grossman²,

Moring³

1993

Anal. Chem.

137

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“…This is found in other articles, too. [10] states, that there is a ''large step from separations of a model solution to a real sample'' and [11] suggest a standard addition procedure.…”

Section: Ce Used For Quality Control: Identification Of Organic Ligandsmentioning

confidence: 99%

Capillary electrophoresis ? a useful tool in speciation investigations

Michalke¹

1996

Analytical and Bioanalytical Chemistry

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1. CE is shown as a tool for a more-dimensional identification of organic metal binding partners. Methods are given for a further improvement of the identification security of the organic ligands [1], when analyzing molecules of nearly equal mobility. CE is used here as a powerful tool for quality assurance and quality control in speciation investigations.2. Methods are presented for a direct separation and identification of different species. As an example, seleno organo compounds are separated from their sulphur analogues in model solutions and native samples. Standard addition methods [1, 2] as well as UV spectra of both species help to identify these molecules as seleno- or sulphur-organo compounds. Further methodological developments and separations are shown for Pt-compounds.

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“…However, this move is still slow to come. Capillary zone electrophoresis (CZE) and micellar electrokinetic chromatography (MEKC) which have already been utilized for some biomedical and clinical applications as reviewed by Deyl and Struzinsky (1991) gain very rapidly in popularity and advances are being made to improve the tot a1 method sensitivity .…”

Section: Summary and Future Trendsmentioning

confidence: 99%

Enantioselective bioanalysis of beta‐blocking agents: Focus on atenolol, betaxolol, carvedilol, metoprolol, pindolol, propranolol and sotalol

Egginger

Lindner

Vandenbosch³

et al. 1993

Biomedical Chromatography

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The recent developments in enantioselective HPLC-separation techniques are impressive and are driven by industrial and academic interests; thus there is for instance a high demand for developing stereoselective assays for chiral drugs in biological fluids. The beta-blocking agents, which possess an amino-propanol- or -ethanol side chain with at least one chiral centre, represent one of the most intensively investigated groups of more than 40 drugs introduced world wide. Seven of the most popular beta-blockers were chosen as representatives: atenolol; betaxolol; carvedilol; metoprolol; pindolol; propranolol; and sotalol, these span the whole range of lipophilicity to hydrophilicity (polarity). Enantioselective HPLC bioassays for these beta-blockers published so far, including techniques based on chiral derivatizing agents (CDAs), chiral stationary phases (CSPs) and chiral mobile phase additives (CMPAs) have been reviewed and documented in the light of general aspects together with pharmacokinetic and pharmacodynamic considerations.

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Capillary zone electrophoresis: its applicability and potential in biochemical analysis

Cited by 90 publications

References 134 publications

Sensitivity Enhancement for Capillary Electrophoresis

Sensitivity Enhancement for Capillary Electrophoresis

Capillary electrophoresis ? a useful tool in speciation investigations

Enantioselective bioanalysis of beta‐blocking agents: Focus on atenolol, betaxolol, carvedilol, metoprolol, pindolol, propranolol and sotalol

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