Capillary zone electrophoresis applied to the determination of the angiotensin-converting enzyme inhibitor cilazapril and its active metabolite in pharmaceuticals and urine

Prieto, José Manuel Compaña; Akesolo, Urtzi; Jiménez, Roberto; Alonso, Rosa M.

doi:10.1016/s0021-9673(01)00565-9

Cited by 24 publications

(8 citation statements)

References 19 publications

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“…These results do not match the previously published data using LC [15], which were around 84% for both compounds. A decrease of a similar proportion was observed in the analysis of the ACE inhibitor cilazapril and its metabolite [26]. Given that the extraction procedure is virtually the same for both the chromatographic and the electrophoretic method, the loss of recovery may be attributed to the presence of endogenous compounds in the urine extract, which modifies the viscosity of the sample solution.…”

Section: Quantitative Determinationmentioning

confidence: 61%

Determination of the angiotensin-converting enzyme inhibitor quinapril and its metabolite quinaprilat in pharmaceuticals and urine by capillary zone electrophoresis and solid-phase extraction

2002

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Quinapril is an antihypertensive drug commonly used in the treatment of hypertension and congestive heart failure. In this work, a capillary zone electrophoresis system is optimized for the analysis of quinapril and its active metabolite quinaprilat in urine, as well as for the determination of the drug and its combination with hydrochlorothiazide in pharmaceuticals. The separation takes place in a fused-silica capillary. The running electrolyte consists of a 60 mM borate buffer solution, pH 9.5. The analysis of urine samples requires a previous extraction step using C8 solid-phase cartridges. Under the optimum experimental conditions, the separation of the two analytes and the internal standard takes less than 5 min. The detection limits obtained (75 and 95 ng/mL for quinapril and quinaprilat, respectively) allow the application of the electrophoretic method to the determination of the drug and its metabolite in urine samples obtained from four patients treated with quinapril.

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Section: Quantitative Determinationmentioning

confidence: 61%

Determination of the angiotensin-converting enzyme inhibitor quinapril and its metabolite quinaprilat in pharmaceuticals and urine by capillary zone electrophoresis and solid-phase extraction

2002

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“…Prieto et al. [] developed a CZE method for the determination of cilazapril and its active metabolite cilazaprilat, both in urine and pharmaceutical tablets. The solid‐phase extraction of urine was done using a C8 cartridge and the 5 min separation was performed in a fused‐silica capillary filled with the running electrolyte, 60 mM borate buffer solution at pH 9.5.…”

Section: Selected Separation Methods For Other Ace Inhibitorsmentioning

confidence: 99%

Separation methods for captopril in pharmaceuticals and biological fluids

Mansour¹,

Danielson²

2012

J of Separation Science

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Captopril (CAP) is an orally active angiotensin‐converting enzyme (ACE) inhibitor and has been widely used for management of hypertension and congestive heart failure. CAP lacks an aromatic chromophore required for facile direct UV detection and also has two chiral centers. These factors can render the determination of CAP in complex matrices challenging. This review covers more than 20 years of analytical research on this drug, focusing mainly on pharmaceutical and biological applications. The primary separation techniques discussed are gas chromatography, liquid chromatography, and capillary electrophoresis. The structures of the CAP derivatizing agents as well as a table summarizing various HPLC methods are provided. A discussion of key recent chromatographic and electrophoretic methods for other ACE inhibitors is also present.

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“…Capillary electrophoretic separation of eight ACEIs: enalapril, lisinopril, quinapril, fosinopril, perindopril, ramipril, benazepril and cilazapril by means of two phosphate buffers (each 100 mM) pH 7.0 and pH 6.25, respectively 180 . Cilazapril and its active metabolite cilazaprilat were analyzed using 60 mM borate buffer pH 9.5, using current of 82 mA and detection at 214 nm 181 . Simultaneous determination of (HCT) and several ACEIs was achieved by CZE using sodium phosphate buffer, pH 7.25, 100 mM), 20 kV as applied voltage and detection at 214 nm 182 , quantification of enalapril, lisinopril, quinapril, fosinopril, perindopril and benazepril is applied by CZE using two phosphate buffers (each 100 mM) at pH 7.0 and 6.25, respectively 183 .…”

Section: (A) Capillary Zone Electrophoresis (Cze)mentioning

confidence: 99%

Analysis of Angiotensin Converting Enzyme Inhibitors and Antagonists

Khashaba

Mohamed

Shahin

2021

Sphinx Journal of Pharmaceutical and Medical Sciences

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The Angiotensin-converting enzyme inhibitors and antagonists are widely used in the management of essential hypertension, stable chronic heart failure, myocardial infarction and diabetic nephropathy, so that specific and sensitive methods are needed for the qualitative and quantitative determinations of these drugs in pharmaceutical dosage forms and in biological material. In the last few years, there was no review published covering all different analytical methods used for the determination of these drugs. The aim of this work is to review the most important recent methods for their analysis in pure forms, in different pharmaceutical dosage forms and in biological fluids due to the great importance of this class of drugs. This review includes two parts: the first part presents the methods applied for the analysis of pharmaceuticals. The second part is devoted to the methods elaborated for the assays in biological material (blood, plasma and urine).

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Capillary zone electrophoresis applied to the determination of the angiotensin-converting enzyme inhibitor cilazapril and its active metabolite in pharmaceuticals and urine

Cited by 24 publications

References 19 publications

Determination of the angiotensin-converting enzyme inhibitor quinapril and its metabolite quinaprilat in pharmaceuticals and urine by capillary zone electrophoresis and solid-phase extraction

Determination of the angiotensin-converting enzyme inhibitor quinapril and its metabolite quinaprilat in pharmaceuticals and urine by capillary zone electrophoresis and solid-phase extraction

Separation methods for captopril in pharmaceuticals and biological fluids

Analysis of Angiotensin Converting Enzyme Inhibitors and Antagonists

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