Capillary thermal desorption unit for near real-time analysis of VOCs at sub-trace levels. Application to the analysis of environmental air contamination and breath samples

Abstract

Please cite this article as: M. Alonso, M. Castellanos, J. Martín, J.M. Sanchez, Capillary thermal desorption unit for near real-time analysis of VOCs at sub-trace levels. Application to the analysis of environmental air contamination and breath samples, Journal of Chromatography B (2008Chromatography B ( ), doi:10.1016Chromatography B ( /j.jchromb.2009 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.Page 1 of 32 A c c e p t e d M a n u s c r i p t 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64

Evaluation of potential breath biomarkers for active smoking: assessment of smoking habits

“…Toluene and xylenes were chosen because VOC emissions by cigarette smoke are usually dominated by benzene and these compounds [30]. 2,5-dimethylfuran was included as recent studies have showed its strong correlation with smoking status [22,[24][25][26][27][28]. 1,3-butadiene was not evaluated as it has been found that the elimination of this compound from the respiratory tract is fast and cannot be detected at the limits of detection levels of the instrumental method used in this study after 30 minutes of smoking [24].…”

“…The microtrap used in this study was specifically developed for the analysis of VOCs in breath samples at ppbv-pptv levels [27]. The device uses a 80-mm-long, 1.35-mm-i.d.…”

“…Previous studies [22,[24][25][26][27]32] have indicated that this compound has a high discrimination power as smoking breath biomarker. As can be seen in Table 4, this compound yielded significant differences in all conditions evaluated and maintained its significant difference between smokers and non-smokers during the whole time interval evaluated.…”

“…In recent years, 2,5-dimethylfuran has been postulated as a strong indicator of smoking status [22,[24][25][26][27] given that this compound is not normally present at detectable levels in the breath of non-smokers. Ashley et al confirmed the discrimination power of this compound in blood samples [28].…”

Breath analysis during one-lung ventilation in cancer patients

“…Benzene represents a compound typically occurring in cigarette smoke and being stored in different body compartments [4,[23][24][25]. In this study, all patients were ex-smokers.…”