Capillary Samples and Hemolysis: Further Considerations

Heenan, Helen; Lunt, Helen; Chan, Huan; Frampton, Chris

doi:10.1177/1932296817700921

Cited by 3 publications

(3 citation statements)

References 5 publications

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“…This finding is in agreement with previous findings of slightly elevated ferritin concentrations in capillary samples . Since hemolysis is a common risk with capillary sample collection and can lead to the leaking of ferritin from within red blood cells, where concentrations are much higher than in plasma, it is possible that the slight elevation in ferritin in traditionally collected capillary samples is the result of contamination with cell‐derived ferritin. With regard to sampling sites, it is further important to note that hemoglobin and hematocrit values obtained from capillary samples showed only poor agreement with those from venous samples.…”

Section: Discussionsupporting

confidence: 92%

“…This finding is in agreement with previous findings of slightly elevated ferritin concentrations in capillary samples. 24 Since hemolysis is a common risk with capillary sample collection 30 and can lead to the leaking of ferritin from within red blood cells, where concentrations are much higher than in plasma, 20 Another important finding of our study was that samples collected using the Noviplex TM were fairly stable over two weeks of storage at room temperature. Ferritin measured from cards stored at room temperature for 2 weeks demonstrated good concordance when compared both to our reference method of venous samples processed immediately (CCC = 0.95) and to Noviplex TM cards analyzed immediately (CCC = 0.94).…”

Section: Impact Of Collection Site On Other Hematological Parametersmentioning

confidence: 74%

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Validity of plasma collection cards for ferritin assessment—A proof‐of‐concept study

Koehler

Marks-Nelson

Braga

et al. 2020

European J of Haematology

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Objectives Iron depletion is common around the world and among certain risk groups in developed countries. The overall purpose was to test the suitability of a novel plasma collection card for minimally invasive iron status assessment. Methods Twenty participants (10 f/10 m) participated in this cross‐sectional study. Ferritin and hemoglobin were measured from blood collected from a forearm vein, serving as reference method. Blood was also collected from the fingertip using the NoviplexTM Plasma Prep Card as well as capillary collection tubes. Results There was substantial concordance between ferritin measured from samples collected via NoviplexTM and venous ferritin (concordance correlation coefficient (CCC) = 0.96) with a mean bias of −0.8 ng/mL. Storing NoviplexTM cards at room temperature for 2 weeks resulted in slightly lower but good concordance when compared to venous ferritin (CCC = 0.95). Capillary hemoglobin (CCC = 0.42) and hematocrit (CCC = 0.25) were in poor agreement with venous data. Conclusions NoviplexTM cards offer a suitable alternative for a minimally invasive ferritin screening in the field when compared to capillary collection tubes. Despite overall substantial concordance with the reference method, findings indicative of iron status abnormalities should be confirmed in venous samples.

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Section: Discussionsupporting

confidence: 92%

Section: Impact Of Collection Site On Other Hematological Parametersmentioning

confidence: 74%

Validity of plasma collection cards for ferritin assessment—A proof‐of‐concept study

Koehler

Marks-Nelson

Braga

et al. 2020

European J of Haematology

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“…This was partly described in the field reports by many study participants presenting with obvious infections. On the other hand, capillary blood samples are slightly more prone for haemolysis (Heenan, Lunt, Chan, & Frampton, ); although this was not noted during handling of the blood specimen, we would like to mention this limitation and its potential impact on increased CRP values.…”

Section: Discussionmentioning

confidence: 99%

Nutritional status of Tajik children and women: Transition towards a double burden of malnutrition

Barth‐Jaeggi

Zandberg

Bahruddinov³

et al. 2019

Maternal & Child Nutrition

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The double burden of malnutrition, an emerging concern in developing countries, can exist at various levels: individual, household, and population. Here, we explore the nutritional status of Tajik women (15–49 years) and children (5–59 months) focusing on overweight/obesity along with undernutrition (underweight, stunting, and micronutrient deficiencies). For this, nutritional markers (haemoglobin (Hb), transferrin receptor (TfR), serum ferritin (Sf), retinol binding protein (RBP), vitamin D, serum folate, and urinary iodine), height, and weight were assessed from 2,145 women and 2,149 children. Dietary intake, weaning, and breastfeeding habits were recorded using a 24‐hr recall and a questionnaire. Overweight (24.5%) and obesity (13.0%) are increasing among Tajik women compared with previous national surveys (2003 and 2009). Prevalence of iron deficiency and anaemia was 38.0% and 25.8%, respectively; 64.5% of women were iodine deficient, 46.5% vitamin A deficient, and 20.5% had insufficient folate levels. Women in rural areas had significantly lower iron status and body mass index and higher iodine intake compared with urban areas; 20.9% of children were stunted, 2.8% wasted, 6.2% underweight, 52.4% iron deficient, and 25.8% anaemic; all more prominent in rural areas. Dietary diversity was higher among urban women. Intraindividual or household double burden was not seen. In summary, double burden of malnutrition constituted an increase in overweight among women, especially in urban areas, and persisting levels of undernutrition (stunting, iron, and vitamin A deficiency), predominately in rural areas. A holistic, innovative approach is needed to improve infant and young children feeding and advise mothers to maintain an adequate diet.

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Blood Glucose Monitoring

Tadi

2010

Diabetes Educ

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With the fastest test time on the market, clocking in at only 3 seconds, and the smallest blood sample requirement of only 0.3 µL, the Element will be an upgrade compared to whatever meter you are currently using! The Element uses Color Code Calibration technology to autocode and features a test strip ejector. The Element glucose meter is also Eocene Systems compatible, allowing patients to easily upload their results to our secure server. The Eocene System enables the patient, authorized members of their healthcare team, and family members to view on-demand utilization/outcome reports and receive automatic alerts for interventions. For more information please contact Infopia USA by visiting www.

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Capillary Samples and Hemolysis: Further Considerations

Cited by 3 publications

References 5 publications

Validity of plasma collection cards for ferritin assessment—A proof‐of‐concept study

Validity of plasma collection cards for ferritin assessment—A proof‐of‐concept study

Nutritional status of Tajik children and women: Transition towards a double burden of malnutrition

Blood Glucose Monitoring

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