Capillary Network Anomalies in Branch Retinal Vein Occlusion on Optical Coherence Tomography Angiography

Rispoli, Marco; Savastano, Maria Cristina; Lumbroso, Bruno

doi:10.1097/iae.0000000000000845

Cited by 111 publications

(87 citation statements)

References 17 publications

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“…This study also suggested that the findings in the DRL were more profound than those in the SRL in RVO subjects. Several other studies have also confirmed those findings (Rispoli, Savastano et al 2015, Adhi, Filho et al 2016) and are reviewed below. Interestingly, Kashani et al also demonstrated that some regions of intraretinal fluid could be visualized on OCTA in analogy to what Matsunaga et al showed for intraretinal fluid in DR (Kashani, Lee et al 2015).…”

Section: Review Of Clinical Studies Utilizing Octasupporting

confidence: 59%

“…These studies have confirmed the above findings and provided novel information about the layer specific nature of impaired perfusion in RVO subjects. For example, several studies of RVO show a decrease in both superficial and deep capillary plexus density, FAZ enlargement, and microvascular abnormalities (Rispoli, Savastano et al 2015, Coscas, Glacet-Bernard et al 2016). One such OCTA study of 54 subjects with RVO (29 CRVO and 25 BRVO) attempted to characterize qualitative OCTA features, such as disruption of the perifoveolar capillary arcade, capillary abnormalities, central cysts, non-perfusion “greyish” areas, and deep capillary plexus (Coscas, Glacet-Bernard et al 2016).…”

Section: Review Of Clinical Studies Utilizing Octamentioning

confidence: 99%

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Optical coherence tomography angiography: A comprehensive review of current methods and clinical applications

Kashani

Chen

Gahm

et al. 2017

Progress in Retinal and Eye Research

749

561

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OCT has revolutionized the practice of ophthalmology over the past 10 to 20 years. Advances in OCT technology have allowed for the creation of novel OCT-based methods. OCT-Angiography (OCTA) is one such method that has rapidly gained clinical acceptance since it was approved by the FDA in late 2016. OCTA images are based on the variable backscattering of light from the vascular and neurosensory tissue in the retina. Since the intensity and phase of backscattered light from retinal tissue varies based on the intrinsic movement of the tissue (e.g. red blood cells are moving, but neurosensory tissue is static), OCTA images are essentially motion-contrast images. This motion-contrast imaging provides reliable, high resolution, and non-invasive images of the retinal vasculature in an efficient manner. In many cases, these images are approaching histology level resolution. This unprecedented resolution coupled with the simple, fast and non-invasive imaging platform have allowed a host of basic and clinical research applications. OCTA has been shown to demonstrate many important clinical findings including areas of macular telangiectasia, impaired perfusion, microaneurysms, capillary remodeling, some types of intraretinal fluid, and neovascularization among many others. More importantly, OCTA provides depth-resolved information that has never before been available. Correspondingly, OCTA has been used to evaluate a spectrum of retinal vascular diseases including diabetic retinopathy (DR), retinal venous occlusion (RVO), uveitis, retinal arterial occlusion, and age-related macular degeneration among others. In this review, we will discuss the methods used to create OCTA images, the practical applications of OCTA in light of invasive dye-imaging studies (e.g. fluorescein angiography) and review clinical studies demonstrating the utility of OCTA for research and clinical practice.

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Section: Review Of Clinical Studies Utilizing Octasupporting

confidence: 59%

Section: Review Of Clinical Studies Utilizing Octamentioning

confidence: 99%

Optical coherence tomography angiography: A comprehensive review of current methods and clinical applications

Kashani

Chen

Gahm

et al. 2017

Progress in Retinal and Eye Research

749

561

View full text Add to dashboard Cite

show abstract

“…A previous study on 10 BRVO eyes showed that OCTA was capable of detecting changes like vessel tortuosity, FAZ enlargement, CNP occurrence, etc. in BRVO eyes . Similar features were also observed in this study.…”

Section: Discussionsupporting

confidence: 92%

“…Few qualitative and quantitative OCTA studies were published on BRVO. In OCTA images of BRVO eyes, the normalized fractal dimension ratio range of 0.0‐0.6 was chosen for computation of CNP areas.…”

Section: Discussionmentioning

confidence: 99%

An automated framework to quantify areas of regional ischemia in retinal vascular diseases with OCT angiography

Anegondi

Chidambara

Bhanushali

et al. 2017

Journal of Biophotonics

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In this observational and cross‐sectional study, capillary nonperfusion (CNP) and vascular changes in branch retinal vein occlusion (BRVO, sample size [n] = 26) and choroidal neovascularization (CNV, n = 29) were evaluated. Subjects underwent imaging using Optical coherence tomography angiography (Angiovue OCTA, RTVue XR, Optovue Inc., Fremont, California). Local fractal analysis was applied to the OCTA images of superficial, deep and choriocapillaris layer. CNP area (BRVO eyes) and vascular parameters were computed using local fractal‐based method. Sensitivity and specificity of vascular parameters were assessed with receiver operating characteristics curve. Automated CNP area showed excellent agreement with manually quantified CNP areas in both superficial (intraclass coefficient [ICC] = 0.96) and deep (ICC = 0.96) layers. BRVO eyes showed significantly altered (P < .05) vascular parameters in both superficial and deep layer as compared to normal eyes (n = 30). CNVM eyes had significantly higher capillary free zones (P < .001) as compared to normal eyes. In normal vs BRVO eyes, vessel density and spacing between the large vessels had similar area under the curve (AUC) (P > .05) in both superficial (0.97 and 0.97, respectively) and deep layer (0.99 and 0.98, respectively). Further, capillary free zones showed high AUC (0.92) in differentiating CNV eyes from normal eyes.

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“…48 Chronic changes at the border such as vascular congestion/dilation, capillary non-perfusion, vessel rarefication, telangiectatic vessels, microaneurysms, retinal neovascularization, and collaterals are visible using OCTA. [49][50][51] OCTA segmentation reveals that the deep plexus may be affected to a greater degree than the superficial plexus in retinal vein occlusions.…”

Section: Retinal Artery and Vein Occlusionsmentioning

confidence: 99%

Advances in Optical Coherence Tomography Angiography

Baumal¹,

Carlo²

2016

US Ophthalmic Review

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Optical coherence tomography angiography (OCTA) is an exciting new imaging technology that allows for non-invasive non-dye-based visualization of blood flow in the posterior pole. The technology has been used to image a variety of chorioretinal disorders including choroidal neovascularization in age-related macular degeneration, diabetic retinopathy, retinal arterial occlusion, retinal vein occlusion, and macular telangiectasia type 2. Continued advances in the software will improve the quality of OCTA and reduce image artifacts.

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Capillary Network Anomalies in Branch Retinal Vein Occlusion on Optical Coherence Tomography Angiography

Cited by 111 publications

References 17 publications

Optical coherence tomography angiography: A comprehensive review of current methods and clinical applications

Optical coherence tomography angiography: A comprehensive review of current methods and clinical applications

An automated framework to quantify areas of regional ischemia in retinal vascular diseases with OCT angiography

Advances in Optical Coherence Tomography Angiography

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