Capillary Microscopy of the Nail Fold in Patients with Psoriasis and Psoriatic Arthritis

Zaric, Dusanka; Clemmensen, Ole; Worm, Anne‐Marie; Stahl, Dorrit

doi:10.1159/000250060

Cited by 29 publications

(24 citation statements)

References 13 publications

(20 reference statements)

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“…They found that twisted and dilated venular branches [21] or coiled, tortuous and short capillaries [22,23] might be characteristic NVC features in PV, whereas a reduction in the capillaries linear density [24], lower mean capillary length [25], a decreased diameter of afferent limb and meandering capillaries with tight terminal convolutions [26] were characteristic of PsA. Similarly to our observations, the well visible sub-papillary venular plexus could turn out to be another distinctive feature while distinguishing between PsA and PV [27,28]. According to some of the authors, the NVC pattern may also be dependent on the nail plate involvement or PsA subtype, i.e.…”

Section: Discussionsupporting

confidence: 82%

Capillaroscopic patterns in patients with systemic sclerosis, psoriasis and alopecia and their correlations with serum concentrations of several angiogenic markers

Chodorowska

Michalska-Jakubus

Bartosińska

et al. 2015

Polish Journal of Public Health

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Introduction. Capillaroscopy is a non-invasive imaging method that allows cutaneous microcirculation to be analyzed. During the last decades, a diagnostic and prognostic potential of nailfold capillaroscopy (NVC) has been gaining increasing appreciation. The main indications include Raynaud phenomenon and scleroderma spectrum diseases, however the usefulness of this technique is also suggested in a variety of non-rheumatic diseases.Aim. To assess capillaroscopic patterns in systemic scleroderma (SSc), psoriasis (PV), psoriatic arthritis (PsA), alopecia areata (AA) and androgenetic alopecia. To evaluate serum levels of several endothelial and angiogenic markers, and their relation to capillaroscopic pattern.Material and methods. There were evaluated 295 patients with systemic scleroderma (SSc), psoriasis (PV), psoriatic arthritis (PsA), alopecia areata (AA) and androgenetic alopecia, as well as age-and sex-matched controls, were examined. In each subject, NVC was performed and serum concentration levels of several angiogenic markers.Results. In SSc three NVC patterns: early, active and late were distinguished. Angiopoietin-2 concentrations were higher and andothelial microparticles were lower in patients with late NVC pattern. We found several differences between the NVC pattern in PV and PsA. No correlations between NVC pattern and serum levels of angiogenic markers were revealed. In AA, we distinguished both normal and abnormal NVC patterns, although the normal patterns were more frequent. Branching capillaries and features of neoformation were often present in patients with the abnormal pattern. In androgenetic alopecia, the normal NVC pattern was most frequently present, however, we found several statistically significant capillarosopic alterations, like branching capillaries, features of neoformation and altered distribution of capillaries.Discussion and Conclusions. Serum levels of Ang-2 and EMPs may reflect capillary damage in SSc. NVC pattern varies between PV and PsA patients. The presence of abnormal NVC patterns in alopecia patients might show the role of disturbances in microcirculation in the diseases. Further studies are required to confirm the hypothesis.

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Section: Discussionsupporting

confidence: 82%

Capillaroscopic patterns in patients with systemic sclerosis, psoriasis and alopecia and their correlations with serum concentrations of several angiogenic markers

Chodorowska

Michalska-Jakubus

Bartosińska

et al. 2015

Polish Journal of Public Health

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“…Cross-linked and tortuous capillaries representing microvascular changes have been observed in a number of studies in patients with psoriasis [11,16,18,40]. Several authors also observed that psoriatic patients have short capillaries by capillaroscopic examination [16][17][18].…”

Section: Discussionmentioning

confidence: 89%

“…Additionally, NVC can provide some information regarding morphostructural changes of capillaries including tortuosity, elongation, dilatation, and crosslinked [11][12][13][14][15]. Several studies with capillaroscopy have been performed in patients with psoriasis, with either nail or joint involvement [16][17][18][19]. One of the advantages of NVC is that individual capillaries can be measured, therefore abnormalities can be determined and quantified [14,20].…”

Section: Introductionmentioning

confidence: 99%

The microvascular and morphostructural changes of nails in psoriatic patients with nail disease; a link between ultrasound and videocapillaroscopy findings in the nailfold

Üreyen¹,

Kara²,

Ertürk³

et al. 2018

Med Ultrason

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Objective: The objective of this study is to evaluate the link between nail fold vessel resistive index (NVRI) measured by ultrasound (US) and capillary loops diameters measured using nailfold videocapillarascopy (NVC), and to assess the morphological appearance of the nail bed in patients with psoriatic nail disease (PND) as compared with healthy controls (HCs).Material and methods: This study was conducted in patients with PND and HCs. General demographic data were collected and clinical assessments were performed for all subjects. The nail plate thickness (NPT) was measured on gray scale using US. The NVRI was measured using color Doppler (CD) US. The measurements of the apical, arterial, venous limb diameters and morpho-structural changes (tortuous, cross-linked capillaries) were assessed using NVC.Results: Thirty-four patients with PND and 15 HCs were enrolled in this study. The two groups were matched for age and body mass index (BMI). Patients with PND had higher NPT and NVRI in comparison with HCs [(20 (17-23) vs 14 (14-15), p<0.001), (0.55 (0.51-0.61) vs 0.43 (0.38-0.49), p<0.001), respectively]. A higher proportion of patients with PND had tortuous capillaries than HCs (62% and 20% respectively, p=0.005). The mean NVRI was higher in patients with PND who had tortuous capillaries than patients who did not have tortuous capillaries (0.58 (0.7) and 0.52 (0.09), respectively p=0.033).Conclusion: Microvascular changes can be detected easily using non-invasive methods such as US and NVC. These methods can provide an objective data to better assess PND.

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“…The fact that we have now been able to show that at least hemorrhagic pericapillary extravasations, bushy-pattern [22] no information 0 no information Houtman [ 18] 51 -37% -2 2 % fourth finger o f both hands fourth finger of both hands Lee et al [25] 27 7.4 not examined Redisch et al [5] 200 0 0 Rios Arzipe et al [19] 15 'normal finding' 'normal finding' Schmidt and Mcnsing [20] 40 'normal finding' 'normal finding' Studcr et al [9] 15 not examined 'seldom' Zaric et al [26] 70 not examined 17%…”

Section: Discussionmentioning

confidence: 99%

Capillary Microscopy of the Nailfold in Healthy Subjects

Heidrich¹,

Voigt²,

Wnuk³

1995

Int J Microcirc

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In a total of 100 healthy subjects (36 males, 64 females) aged between 5 and 58 years, capillary microscopy of the nailfold was performed in all the fingers of both hands. The aim of this study was to determine whether capillary abnormalities, hitherto regarded as pathological, were to be found, and if so, to establish their frequency and nature. Capillary branchings – on average 4-5/person – were seen in 78% of the subjects investigated, and proved to be most common in digits IV and V of both hands. Of the subjects investigated, 94% showed meanderings, 64% tortuous loops, 25% hemorrhagic extravasations, and 19% apical dilatations of the capillaries. Only a single case of a giant loop was seen. Neither avascular fields, stasis nor reversion of blood flow were seen. Maricq’s venule index was increased in 3 subjects. These findings clearly indicate that the significance of deviating capillary patterns need to be reconsidered, for branchings or hemorrhagic extravasations can certainly be found in healthy subjects.

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Capillary Microscopy of the Nail Fold in Patients with Psoriasis and Psoriatic Arthritis

Cited by 29 publications

References 13 publications

Capillaroscopic patterns in patients with systemic sclerosis, psoriasis and alopecia and their correlations with serum concentrations of several angiogenic markers

Capillaroscopic patterns in patients with systemic sclerosis, psoriasis and alopecia and their correlations with serum concentrations of several angiogenic markers

The microvascular and morphostructural changes of nails in psoriatic patients with nail disease; a link between ultrasound and videocapillaroscopy findings in the nailfold

Capillary Microscopy of the Nailfold in Healthy Subjects

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