Capillary growth in chronically stimulated adult skeletal muscle as studied by intravital microscopy and histological methods in rabbits and rats

Myrhage, Rhagnar; Hudlická, O

doi:10.1016/0026-2862(78)90046-8

Cited by 124 publications

(81 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The latter suggestion seems unlikely since, as muscle mass is lost during undernutrtion, there would have to be a disproportionate loss or closing of capillaries to affect O 2 supply. While there is capillary growth in chronically stimulated skeletal muscle (Myrhage and Hudlicka, 1978), the present author is unaware of studies on capillarization of skeletal muscle in malnourished humans or animals, and there do not seem to be any studies of cardiac output in undernourished subjects during either submaximal or maximal work. The effects of anemia on work capacity will be discussed below.…”

Section: Acute Caloric Restrictionmentioning

confidence: 91%

Nutritional status and physical work capacity

Spurr

1983

American J Phys Anthropol

117

View full text Add to dashboard Cite

The functional consequences of nutritional intake and resulting nutritional status are reviewed in terms of maximal oxygen consumption, physical work capacity, heart rate response to exercise, work productivity, and endurance at submaximal work loads. The results of both acute (laboratory) and chronic (naturally occurring) malnutrition are considered as well as the effects of dietary supplementation and recovery from previously existing undernutrition. Obesity and anemia are also treated as separate but related nutritional entities.

show abstract

Section: Acute Caloric Restrictionmentioning

confidence: 91%

Nutritional status and physical work capacity

Spurr

1983

American J Phys Anthropol

117

View full text Add to dashboard Cite

show abstract

“…The area occupied by blood vessels correlates with ongoing oxidative metabolic demands in muscle fibers (16,17). Although this value was similar in both groups at PD10, enucleated rats showed a higher percentage of area containing blood vessels than in their control counterparts at PD 60 (26%) and PD160 (36%).…”

Section: Resultsmentioning

confidence: 89%

Late onset muscle plasticity in the whisker pad of enucleated rats

Toscano-Márquez¹,

Martínez‐Martínez²,

Manjarrez³

et al. 2008

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

Blindness leads to a major reorganization of neural pathways associated with touch. Because incoming somatosensory information influences motor output, it is plausible that motor plasticity occurs in the blind. In this work, we evaluated this issue at the peripheral level in enucleated rats. Whisker muscles in enucleated rats 160 days of age or older showed increased cytochrome oxidase activity, capillary density, motor plate size, and amplitude of evoked field potentials as compared with their control counterparts. Such differences were not observed at ages 10 and 60 days, the capillary density was the exception being greater in the enucleated rat at the latter age. Interestingly, there was a trend to increased neurotrophin-3 concentrations in the whisker pads of enucleated rats throughout postnatal development. Our results show that neonatal enucleation leads to late onset plasticity of the whisker's motor system. blindness ͉ metabolic activity ͉ motor plasticity ͉ motor plate potentials ͉ skeletal muscle I n mammals, the loss of vision leads to a large scale sensory reorganization of the brain. Somatosensory and auditory areas enlarge whereas the former visual regions become activated by somatosensory and auditory information (1). These functional modifications are associated with the reorganization of their anatomical substrate (2, 3). The reorganized brain allows the blind to develop the somatosensory and auditory abilities that distinguish them from sighted subjects (4, 5).Somatosensory information calibrates motor output (5, 6-8). Hence, one might expect certain degree of motor plasticity in blind subjects. Accordingly, studies have shown incremental increases in the activity of glutamate dehydrogenase and in the size of neurons located in the motor cortex after visual deprivation (9). Magnetic resonance studies in blind humans have also documented a decreased functional connectivity to motor areas (9, 10), increments in the volume of cortical gray matter associated with sensory-motor cortices (11), and in the volume of the cortico-spinal tract (9). Whether motor plasticity in the blind extends to more peripheral levels is unknown.A good model system to test whether peripheral motor plasticity occurs in the blind is the sensory-motor system controlling whisking in rodents. Sensory information arising from the whiskers calibrates their movements (12) while motor activity modulates sensory information influx (13, 14). Our work was aimed at evaluating the morpho-functional plasticity ongoing in the intrinsic motor apparatus of the facial whiskers of neonatally enucleated rats. The time course and the possible relationship between the plastic response and neurotrophin-3 concentrations were analyzed. Our results document late onset morpho-functional plasticity in the intrinsic musculature of whisker follicles in rats enucleated at birth. The evidence we provide suggests that this plastic response is associated with increments in the concentrations of neurotrophin-3 in the whisker pad. Hence, blind individuals ...

show abstract

“…(Sobrevia et al 1994 b) demonstrate that human fetal endothelium is altered functionally in diabetic pregnancy. Rat fast muscles stimulated electrically for 7 days had a 20 % increase in the number of capillaries, indicative of capillary growth (Myrhage & Hudlicka, 1978); muscles stimulated for 2 days had a capillary supply similar to controls (Brown et al 1993). The purpose of this study was to investigate the possible activation of capillary endothelium prior to increased numbers, using the thymidine analogue 2-bromo-deoxyuridine (BrdU) to demonstrate DNA synthesis.…”

mentioning

confidence: 99%

“…Male Sprague-Dawley rats had electrodes implanted under fluothane anaesthesia as described previously (Myrhage & Hudlicka, 1978). Indirect stimulation of the lower limb physiological flexors was carried out for 2 or 7 days (10 Hz, 0 3 ms pulse width, 2-5 V, 8 h day-').…”

mentioning

confidence: 99%

Microvascular & Endothelial Physiology

1995

The Journal of Physiology

View full text Add to dashboard Cite

Capillary growth in chronically stimulated adult skeletal muscle as studied by intravital microscopy and histological methods in rabbits and rats

Cited by 124 publications

References 24 publications

Nutritional status and physical work capacity

Nutritional status and physical work capacity

Late onset muscle plasticity in the whisker pad of enucleated rats

Microvascular & Endothelial Physiology

Contact Info

Product

Resources

About