Capillary GC using pyridyl β‐cyclodextrin stationary phase

Abstract

A new beta-CD derivative, heptakis [2,6-di-O-pentyl-3-O-(4'-chloro-5'-pyridylmethyl)]-beta-CD, was synthesized by the selective introduction of a pyridyl group on the 3-positions of beta-CD. The chromatographic properties of the pyridyl beta-CD derivative were studied by using it as the stationary phase in capillary GC. The polarity of the prepared stationary phase was moderate, and the separation results demonstrated that the prepared stationary phase possessed excellent separation ability and chiral recognition for a wide range of analytes. Not only the aromatic positional isomers, such as o-, m-, p-xylene and alpha-, beta-naphthol isomers, but also some compounds with multi-stereogenic centers, such as n-(1-methylpropyl)-3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarboxamide and n-(1-methylpropyl)-3-(2-chloro-3,3,3-trifluoropropenyl)-2,2-dimethylcyclopropanecarboxamide with three stereogenic centers including eight configurational isomers, were successfully separated. The results also indicated that the polarity of the beta-CD derivative, and the hydrogen bonding between the beta-CD derivative, and the analytes had a very important effect on separation.

A New Capillary Gas Chromatography Column Based on Poly(ethylene glycol) Methyl Ether‐Functionalized Calix[4]arene

“…[1] A selective stationary phase and an efficient column preparation method are critical factors in GC technology. [2] In recent years, several typologies of materials with different structures and properties have been developed and proposed as GC stationary phases, such as polymers, [3][4][5] ionic liquids, [6,7] macrocycles, [8,9] metal-organic frame-works [10,11] and carbon nanotubes. [12][13][14] Among them, macrocycles have emerged due to their special chromatographic selectivity and separation mechanisms, resulting from their unique three-dimensional structures and outstanding thermal stability.…”